3',4',5,5',6,7-HexamethoxyflavoneCAS# 29043-07-0 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 29043-07-0 | SDF | Download SDF |
| PubChem ID | 185670 | Appearance | Powder |
| Formula | C21H22O8 | M.Wt | 402.4 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,6,7-trimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one | ||
| SMILES | COC1=CC(=CC(=C1OC)OC)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)OC | ||
| Standard InChIKey | DYDFNKUHYXHWFM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C21H22O8/c1-23-15-7-11(8-16(24-2)19(15)26-4)13-9-12(22)18-14(29-13)10-17(25-3)20(27-5)21(18)28-6/h7-10H,1-6H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 5,6,7,3',4',5'-Hexamethoxyflavone(HMF) has anticancer activities, it inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle. HMF may potentiate Cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel activities through both elevation of cAMP level and binding to CFTR protein pathways, HMF may be developed as a new drug in the therapy of CFTR-related diseases such as bronchiectasis and habitual constipation. | |||||
3',4',5,5',6,7-Hexamethoxyflavone Dilution Calculator
3',4',5,5',6,7-Hexamethoxyflavone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4851 mL | 12.4254 mL | 24.8509 mL | 49.7018 mL | 62.1272 mL |
| 5 mM | 0.497 mL | 2.4851 mL | 4.9702 mL | 9.9404 mL | 12.4254 mL |
| 10 mM | 0.2485 mL | 1.2425 mL | 2.4851 mL | 4.9702 mL | 6.2127 mL |
| 50 mM | 0.0497 mL | 0.2485 mL | 0.497 mL | 0.994 mL | 1.2425 mL |
| 100 mM | 0.0249 mL | 0.1243 mL | 0.2485 mL | 0.497 mL | 0.6213 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Polymethoxylated flavonoids activate cystic fibrosis transmembrane conductance regulator chloride channel].[Pubmed:25896054]
Sheng Li Xue Bao. 2015 Apr 25;67(2):225-34.
Cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent chloride channel, plays key roles in fluid secretion in serous epithelial cells. Previously, we identified two polymethoxylated flavonoids, 3',4',5,5',6,7-hexamethoxyflavone (HMF) and 5-hydroxy-6,7,3',4'-tetramethoxyflavone (HTF) which could potentiate CFTR chloride channel activities. The present study was aimed to investigate the potentiation effects of HMF and HTF on CFTR Cl(-) channel activities by using a cell-based fluorescence assay and the short circuit Ussing chamber assay. The results of cell-based fluorescence assay showed that both HMF and HTF could dose-dependently potentiate CFTR Cl(-) channel activities in rapid and reversible ways, and the activations could be reversed by the CFTR blocker CFTRinh-172. Notably, HMF showed the highest affinity (EC50 = 2 mumol/L) to CFTR protein among the flavonoid CFTR activators identified so far. The activation of CFTR by HMF or HTF was forskolin (FSK) dependent. Both compounds showed additive effect with FSK and 3-Isobutyl-1-methylx (IBMX) in the activation of CFTR, while had no additive effect with genistein (GEN). In ex vivo studies, HMF and HTF could stimulate transepithelial Cl(-) secretion in rat colonic mucosa and enhance fluid secretion in mouse trachea submucosal glands. These results suggest that HMF and HTF may potentiate CFTR Cl(-) channel activities through both elevation of cAMP level and binding to CFTR protein pathways. The results provide new clues in elucidating structure and activity relationship of flavonoid CFTR activators. HMF might be developed as a new drug in the therapy of CFTR-related diseases such as bronchiectasis and habitual constipation.
