Clausine Z

CAS# 866111-14-0

Clausine Z

Catalog No. BCN4414----Order now to get a substantial discount!

Product Name & Size Price Stock
Clausine Z: 5mg $886 In Stock
Clausine Z: 10mg Please Inquire In Stock
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Quality Control of Clausine Z

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Chemical structure

Clausine Z

3D structure

Chemical Properties of Clausine Z

Cas No. 866111-14-0 SDF Download SDF
PubChem ID 11436094 Appearance Powder
Formula C13H9NO3 M.Wt 227.2
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,6-dihydroxy-9H-carbazole-3-carbaldehyde
SMILES C1=CC2=C(C=C1O)C3=CC(=CC(=C3N2)O)C=O
Standard InChIKey FKDULSCBYNXNMP-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H9NO3/c15-6-7-3-10-9-5-8(16)1-2-11(9)14-13(10)12(17)4-7/h1-6,14,16-17H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Clausine Z

The herbs of Clausena excavata

Biological Activity of Clausine Z

Description1. Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
TargetsCDK

Clausine Z Dilution Calculator

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Clausine Z Molarity Calculator

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Preparing Stock Solutions of Clausine Z

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4014 mL 22.007 mL 44.0141 mL 88.0282 mL 110.0352 mL
5 mM 0.8803 mL 4.4014 mL 8.8028 mL 17.6056 mL 22.007 mL
10 mM 0.4401 mL 2.2007 mL 4.4014 mL 8.8028 mL 11.0035 mL
50 mM 0.088 mL 0.4401 mL 0.8803 mL 1.7606 mL 2.2007 mL
100 mM 0.044 mL 0.2201 mL 0.4401 mL 0.8803 mL 1.1004 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Clausine Z

Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5.[Pubmed:16124414]

Pharmazie. 2005 Aug;60(8):637-9.

A new carbazole alkaloid, named Clausine Z, has been isolated from the stems and leaves of Clausena excavata Burm. (Rutaceae). Its structure was established by spectroscopic methods. The compound exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.

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