Clausine ZCAS# 866111-14-0 |
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| Cas No. | 866111-14-0 | SDF | Download SDF |
| PubChem ID | 11436094 | Appearance | Powder |
| Formula | C13H9NO3 | M.Wt | 227.2 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1,6-dihydroxy-9H-carbazole-3-carbaldehyde | ||
| SMILES | C1=CC2=C(C=C1O)C3=CC(=CC(=C3N2)O)C=O | ||
| Standard InChIKey | FKDULSCBYNXNMP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H9NO3/c15-6-7-3-10-9-5-8(16)1-2-11(9)14-13(10)12(17)4-7/h1-6,14,16-17H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Clausena excavata
| Description | 1. Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro. |
| Targets | CDK |
Clausine Z Dilution Calculator
Clausine Z Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.4014 mL | 22.007 mL | 44.0141 mL | 88.0282 mL | 110.0352 mL |
| 5 mM | 0.8803 mL | 4.4014 mL | 8.8028 mL | 17.6056 mL | 22.007 mL |
| 10 mM | 0.4401 mL | 2.2007 mL | 4.4014 mL | 8.8028 mL | 11.0035 mL |
| 50 mM | 0.088 mL | 0.4401 mL | 0.8803 mL | 1.7606 mL | 2.2007 mL |
| 100 mM | 0.044 mL | 0.2201 mL | 0.4401 mL | 0.8803 mL | 1.1004 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5.[Pubmed:16124414]
Pharmazie. 2005 Aug;60(8):637-9.
A new carbazole alkaloid, named Clausine Z, has been isolated from the stems and leaves of Clausena excavata Burm. (Rutaceae). Its structure was established by spectroscopic methods. The compound exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
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