Clemastanin BCAS# 112747-98-5 |
Quality Control & MSDS
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| Cas No. | 112747-98-5 | SDF | Download SDF |
| PubChem ID | 10009802 | Appearance | Powder |
| Formula | C32H44O16 | M.Wt | 684.7 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-[[(3R,4R,5S)-4-(hydroxymethyl)-5-[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]oxolan-3-yl]methyl]-2-methoxyphenoxy]oxane-3,4,5-triol | ||
| SMILES | COC1=C(C=CC(=C1)CC2COC(C2CO)C3=CC(=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O)OC)OC5C(C(C(C(O5)CO)O)O)O | ||
| Standard InChIKey | PBLWZMSRSJTRHJ-NCIRKIHRSA-N | ||
| Standard InChI | InChI=1S/C32H44O16/c1-42-20-8-14(3-5-18(20)45-31-28(40)26(38)24(36)22(11-34)47-31)7-16-13-44-30(17(16)10-33)15-4-6-19(21(9-15)43-2)46-32-29(41)27(39)25(37)23(12-35)48-32/h3-6,8-9,16-17,22-41H,7,10-13H2,1-2H3/t16-,17-,22+,23+,24+,25+,26-,27-,28+,29+,30+,31+,32+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Stellera chamaejasme L.
| Description | 1. Clemastanin B exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. 2. Clemastanin B has antioxidant and anti-inflammatory activities. |
| Targets | Influenza virus | Immunology & Inflammation related |
Clemastanin B Dilution Calculator
Clemastanin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4605 mL | 7.3025 mL | 14.6049 mL | 29.2099 mL | 36.5123 mL |
| 5 mM | 0.2921 mL | 1.4605 mL | 2.921 mL | 5.842 mL | 7.3025 mL |
| 10 mM | 0.146 mL | 0.7302 mL | 1.4605 mL | 2.921 mL | 3.6512 mL |
| 50 mM | 0.0292 mL | 0.146 mL | 0.2921 mL | 0.5842 mL | 0.7302 mL |
| 100 mM | 0.0146 mL | 0.073 mL | 0.146 mL | 0.2921 mL | 0.3651 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro.[Pubmed:23403777]
Int J Mol Med. 2013 Apr;31(4):867-73.
Clemastanin B, 7S,8R,8'R-(-)-lariciresinol-4,4'-bis-O-beta-D-glucopyranoside, is one of the major lignans extracted from Isatis indigotica root (IIR). In this study, the anti-influenza activities of Clemastanin B were evaluated in vitro. Clemastanin B was found to inhibit different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian influenza viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC50 0.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV). An apparent virus titer reduction was detected when MDCK cells were treated with Clemastanin B after viral infection, particularly at the early stage, and the ribonucleoprotein (RNP) of the influenza virus was retained in the nucleus after treatment with Clemastanin B. These results demonstrated that Clemastanin B targets viral endocytosis, uncoating or RNP export from the nucleus. Furthermore, treatment with Clemastanin B did not easily result in the emergence of viral drug resistance. The effects of Clemastanin B demonstrated in this study may promote the antiviral study of IIR, but additional studies are required to define the anti-influenza mechanism(s).
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