(24R)-MC 976Vitamin D3 derivative CAS# 112828-09-8 |
- 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
Catalog No.:BCC1309
CAS No.:163018-26-6
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| Cas No. | 112828-09-8 | SDF | Download SDF |
| PubChem ID | 71576664 | Appearance | Powder |
| Formula | C27H42O3 | M.Wt | 414.62 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-cyclopropyl-5-hydroxypentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol | ||
| SMILES | CC(CCC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C | ||
| Standard InChIKey | NQHWMFGCRBTMOO-AOLSRVLUSA-N | ||
| Standard InChI | InChI=1S/C27H42O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h7,10,17,20,22-26,28-30H,2,4-6,8-9,11-16H2,1,3H3/b19-7+,21-10-/t17-,22-,23-,24+,25-,26+,27-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | (24R)-MC 976 is a Vitamin D3 derivative. References: | |||||
(24R)-MC 976 Dilution Calculator
(24R)-MC 976 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4118 mL | 12.0592 mL | 24.1185 mL | 48.2369 mL | 60.2962 mL |
| 5 mM | 0.4824 mL | 2.4118 mL | 4.8237 mL | 9.6474 mL | 12.0592 mL |
| 10 mM | 0.2412 mL | 1.2059 mL | 2.4118 mL | 4.8237 mL | 6.0296 mL |
| 50 mM | 0.0482 mL | 0.2412 mL | 0.4824 mL | 0.9647 mL | 1.2059 mL |
| 100 mM | 0.0241 mL | 0.1206 mL | 0.2412 mL | 0.4824 mL | 0.603 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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MC 969 is an analog of the calcemic drug 1α-hydroxyvitamin D3 (1α-OH-D3). Metabolites of MC 969 were generated in an in vitro human hepatocyte cell model (Hep 3B), leading to identify the 24 (R) alcohols metabolite of MC 969, (24R)-MC 976.
In vitro: Metabolic study of MC 969 were generated in an in vitro human hepatocyte cell model, Hep 3B. It was found that unequivocal identification of the 24-keto- and the two epimeric 24-alcohol metabolites (24 (R,S) alcohols of MC 969) was provided. In the competition studies, MC 969 was able to inhibit 25-hydroxylation of tritiated vitamin D3 more effectively than lα-OH-D3 itself, indicating that the vitamin D3-25-hydroxylase may be responsible for generation of one or more of the metabolites observed [1].
In vivo: No animal in-vivo data available currently.
Clinical trial: (24R)-MC 976 is currently in the preclinical developlent stage and no clinical data are available.
Reference:
[1] Strugnell S, Calverley MJ, Jones G. Metabolism of a cyclopropane-ring-containing analog of 1 alpha-hydroxyvitamin D3 in a hepatocyte cell model. Identification of 24-oxidized metabolites. Biochem Pharmacol. 1990;40(2):333-41.
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