OsthenoneCAS# 112789-90-9 |
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| Cas No. | 112789-90-9 | SDF | Download SDF |
| PubChem ID | 13917410 | Appearance | Powder |
| Formula | C14H12O4 | M.Wt | 244.24 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 7-methoxy-8-[(E)-3-oxobut-1-enyl]chromen-2-one | ||
| SMILES | CC(=O)C=CC1=C(C=CC2=C1OC(=O)C=C2)OC | ||
| Standard InChIKey | FNFVAKUIMOKUQL-ZZXKWVIFSA-N | ||
| Standard InChI | InChI=1S/C14H12O4/c1-9(15)3-6-11-12(17-2)7-4-10-5-8-13(16)18-14(10)11/h3-8H,1-2H3/b6-3+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Murraya exotica
| Description | 1. Osthenone shows strong activity against the cancer cell lines, whereas it has weak antiproliferative activity against the normal human cell lines. |
Osthenone Dilution Calculator
Osthenone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0943 mL | 20.4717 mL | 40.9433 mL | 81.8867 mL | 102.3583 mL |
| 5 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL | 16.3773 mL | 20.4717 mL |
| 10 mM | 0.4094 mL | 2.0472 mL | 4.0943 mL | 8.1887 mL | 10.2358 mL |
| 50 mM | 0.0819 mL | 0.4094 mL | 0.8189 mL | 1.6377 mL | 2.0472 mL |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 0.8189 mL | 1.0236 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.[Pubmed:11497276]
Anticancer Res. 2001 May-Jun;21(3B):1905-11.
33 coumarins, mainly the simple isopentenylated coumarins and derived pyrano- and furanocoumarins, were examined for their antiproliferative activity towards several cancer and normal human cell lines. The pyrano- and furanocoumarins showed strong activity against the cancer cell lines, whereas they had weak antiproliferative activity against the normal human cell lines. The decreasing rank order of potency was Osthenone (10), clausarin (25), clausenidin (26), dentatin (24), nordentatin (23), imperatorin (29), seselin (27), xanthyletin (21), suberosin (17), phebalosin (8) and osthol (12). The structure-activity relationship established from the results revealed that the 1,1-dimethylallyl and isopentenyl groups have an important role for antiproliferative activity.
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