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24R-Calcipotriol

CAS# 112827-99-3

24R-Calcipotriol

Catalog No. BCC1304----Order now to get a substantial discount!

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24R-Calcipotriol: 5mg $2921 In Stock
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Quality Control of 24R-Calcipotriol

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Chemical structure

24R-Calcipotriol

3D structure

Chemical Properties of 24R-Calcipotriol

Cas No. 112827-99-3 SDF Download SDF
PubChem ID 9547353 Appearance Powder
Formula C27H40O3 M.Wt 412.6
Type of Compound N/A Storage Desiccate at -20°C
Synonyms PRI 2202; Impurity D of Calcipotriol
Solubility DMSO : ≥ 100 mg/mL (242.37 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
SMILES CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C
Standard InChIKey LWQQLNNNIPYSNX-CIJZWTHJSA-N
Standard InChI InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10-/t17-,22-,23-,24+,25+,26+,27-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of 24R-Calcipotriol

Description24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

References:
[1]. Gocek, Elzbieta; Kielbinski, Marek; Baurska, Hanna et al. Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations. Leukemia Research (2010), 34(5), 649-657. [2]. Gocek, Elzbieta; Kielbinski, Marek; Wylob, Paulina et al. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Steroids (2008), 73(14), 1359-1366. [3]. Wietrzyk, Joanna; Nevozhay, Dmitry; Filip, Beata et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Research (2007), 27(5A), 3387-3398. [4]. Wietrzyk, Joanna; Chodynski, Michal; Fitak, Hanna et al. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anti-Cancer Drugs (2007), 18(4), 447-457.

24R-Calcipotriol Dilution Calculator

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24R-Calcipotriol Molarity Calculator

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Preparing Stock Solutions of 24R-Calcipotriol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4237 mL 12.1183 mL 24.2365 mL 48.4731 mL 60.5914 mL
5 mM 0.4847 mL 2.4237 mL 4.8473 mL 9.6946 mL 12.1183 mL
10 mM 0.2424 mL 1.2118 mL 2.4237 mL 4.8473 mL 6.0591 mL
50 mM 0.0485 mL 0.2424 mL 0.4847 mL 0.9695 mL 1.2118 mL
100 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.4847 mL 0.6059 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on 24R-Calcipotriol

24R-Calcipotriol is impurity of Calcipotriol. Calcipotriol (MC 903; Calcipotriene) is a VDR-like Receptors.

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Description

24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

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