CrotonosideCAS# 1818-71-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1818-71-9 | SDF | Download SDF |
PubChem ID | 65085 | Appearance | Powder |
Formula | C10H13N5O5 | M.Wt | 283.24 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-2-one | ||
SMILES | C1=NC2=C(NC(=O)N=C2N1C3C(C(C(O3)CO)O)O)N | ||
Standard InChIKey | MIKUYHXYGGJMLM-UUOKFMHZSA-N | ||
Standard InChI | InChI=1S/C10H13N5O5/c11-7-4-8(14-10(19)13-7)15(2-12-4)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Crotonoside is one compound of an antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine. |
Targets | Adenosine Receptor |
In vitro | ANTITUMOR AND IMMUNITY-REGULATING PHARMACEUTICAL COMPOSITION OF TRADITIONAL CHINESE MEDICINE, PREPARATION METHOD AND USE FOR SAME[Reference: WebLink]PAT - WO2010148577An antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine, preparation method and use for same. The pharmaceutical composition comprises Semen crotonis pulveratum, Radix Platycodi and Fritillaria with a weight ratio of 1:3:3. Semen crotonis pulveratum contains 8-12% croton oil and 1.47-5.59% Crotonoside, and is prepared by extracting croton kernel, isolating croton oil and croton dregs, and proportionately adding croton oil into croton dregs. Said composition is both curative and highly safe. |
In vivo | Isolation of isoguanosine from Croton tiglium and its antitumor activity.[Pubmed: 10319142]Arch Pharm Res. 1994 Apr;17(2):115-8.This paper describes the isolation of isoguanosine(Crotonoside) from Croton tiglium L. and its cytotoxic effect against several tumor cell lines in culture and newly reports that isoguanosine(Crotonoside) has an antitumor activity against implanted S-180 ascitic tumor mice. |
Structure Identification | J Phys Chem A. 2013 Jul 18;117(28):5715-25.Mechanism of the deamination reaction of isoguanine: a theoretical investigation.[Pubmed: 23789717]
Biochemistry. 1994 Oct 11;33(40):12119-26.Isoguanosine substitution of conserved adenosines in the hammerhead ribozyme.[Pubmed: 7918433]
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Crotonoside Dilution Calculator
Crotonoside Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.5306 mL | 17.6529 mL | 35.3057 mL | 70.6115 mL | 88.2644 mL |
5 mM | 0.7061 mL | 3.5306 mL | 7.0611 mL | 14.1223 mL | 17.6529 mL |
10 mM | 0.3531 mL | 1.7653 mL | 3.5306 mL | 7.0611 mL | 8.8264 mL |
50 mM | 0.0706 mL | 0.3531 mL | 0.7061 mL | 1.4122 mL | 1.7653 mL |
100 mM | 0.0353 mL | 0.1765 mL | 0.3531 mL | 0.7061 mL | 0.8826 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Mechanism of the deamination reaction of isoguanine: a theoretical investigation.[Pubmed:23789717]
J Phys Chem A. 2013 Jul 18;117(28):5715-25.
Mechanisms of the deamination reactions of isoguanine with H2O, OH(-), and OH(-)/H2O and of protonated isoguanine (isoGH(+)) with H2O have been investigated by theoretical calculations. Eight pathways, paths A-H, have been explored and the thermodynamic properties (DeltaE, DeltaH, and DeltaG), activation energies, enthalpies, and Gibbs energies of activation were calculated for each reaction investigated. Compared with the deamination reaction of isoguanine or protonated isoguanine (isoGH(+)) with water, the deamination reaction of isoguanine with OH(-) shows a lower Gibbs energy of activation at the rate-determining step, indicating that the deamination reaction of isoguanine is favorably to take place for the deprotonated form isoG(-) with water. With the assistance of an extra water, the reaction of isoguanine with OH(-)/H2O, pathways F and H, are found to be the most feasible pathways in aqueous solution due to their lowest Gibbs energy of activation of 174.7 and 172.6 kJ mol(-1), respectively, at the B3LYP/6-311++G(d,p) level of theory.
Isoguanosine substitution of conserved adenosines in the hammerhead ribozyme.[Pubmed:7918433]
Biochemistry. 1994 Oct 11;33(40):12119-26.
Isoguanosine has been incorporated into a 34-mer hammerhead ribozyme by the solid-phase phosphoramidite method, using an acetamidine base protecting group. The activity of the hammerhead ribozyme when singly mutated to isoguanosine at the adenosine positions 6, 9, and 13 was 1-2-fold less than the wild-type activity. Mutations to 2-aminopurine ribonucleoside at positions 9 and 13 were 5-fold reduced in activity, but that at position 6 was approximately 30-fold reduced. These results support the view that the 6-amino functions of A6, A9, and A13 are not very important for catalysis. The 2-position of A6 tolerates a carbonyl function but not an amino group, whereas A9 and A13 tolerate both functional groups. The tolerance of a 2-amino group at A9 and A13 makes G(anti)/A(anti) Watson-Crick type base mispairing for G12/A9 and A13/G8 unlikely.
Isolation of isoguanosine from Croton tiglium and its antitumor activity.[Pubmed:10319142]
Arch Pharm Res. 1994 Apr;17(2):115-8.
This paper describes the isolation of isoguanosine from Croton tiglium L. and its cytotoxic effect against several tumor cell lines in culture and newly reports that isoguanosine has an antitumor activity against implanted S-180 ascitic tumor mice. Isoguanosine is effective at the dose of 24 mg/kg/day x 5, with T/C value of 168%. Isoguanosine inhibits the growth of S-180 and Ehrlich solid tumor in mice at the optimal doses of 96 mg/kg/day x 12 and 48 mg/kg/day x 12, with 1-T/C values of 65% and 60%, respectively.