PD 160170Selective non-peptide NPY Y1 receptor antagonist CAS# 181468-88-2 |
- Calpain Inhibitor I, ALLN
Catalog No.:BCC1233
CAS No.:110044-82-1
- Calpeptin
Catalog No.:BCC2351
CAS No.:117591-20-5
- Acetyl-Calpastatin (184-210) (human)
Catalog No.:BCC2350
CAS No.:123714-50-1
- Calpain Inhibitor II, ALLM
Catalog No.:BCC1234
CAS No.:136632-32-1
- MDL 28170
Catalog No.:BCC2352
CAS No.:88191-84-8
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 181468-88-2 | SDF | Download SDF |
PubChem ID | 9820766 | Appearance | Powder |
Formula | C18H17N3O4S | M.Wt | 371.41 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 100 mM in DMSO | ||
Chemical Name | 5-nitro-6-(2-propan-2-ylphenyl)sulfonylquinolin-8-amine | ||
SMILES | CC(C)C1=CC=CC=C1S(=O)(=O)C2=C(C3=C(C(=C2)N)N=CC=C3)[N+](=O)[O-] | ||
Standard InChIKey | YUVNGBZROXQYQH-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C18H17N3O4S/c1-11(2)12-6-3-4-8-15(12)26(24,25)16-10-14(19)17-13(7-5-9-20-17)18(16)21(22)23/h3-11H,19H2,1-2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM). |
PD 160170 Dilution Calculator
PD 160170 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.6924 mL | 13.4622 mL | 26.9244 mL | 53.8488 mL | 67.3111 mL |
5 mM | 0.5385 mL | 2.6924 mL | 5.3849 mL | 10.7698 mL | 13.4622 mL |
10 mM | 0.2692 mL | 1.3462 mL | 2.6924 mL | 5.3849 mL | 6.7311 mL |
50 mM | 0.0538 mL | 0.2692 mL | 0.5385 mL | 1.077 mL | 1.3462 mL |
100 mM | 0.0269 mL | 0.1346 mL | 0.2692 mL | 0.5385 mL | 0.6731 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Colutehydroquinone
Catalog No.:BCN8239
CAS No.:181311-16-0
- Taxuspine W
Catalog No.:BCN6937
CAS No.:181309-92-2
- Ginsenoside F4
Catalog No.:BCN2881
CAS No.:181225-33-2
- DEL-22379
Catalog No.:BCC6521
CAS No.:181223-80-3
- Almotriptan Malate
Catalog No.:BCC5045
CAS No.:181183-52-8
- Co 102862
Catalog No.:BCC7439
CAS No.:181144-66-1
- 4,5-Dimethoxycanthin-6-one
Catalog No.:BCN1143
CAS No.:18110-87-7
- 5-Hydroxy-4-methoxycanthin-6-one
Catalog No.:BCN1142
CAS No.:18110-86-6
- Proflavine Hemisulfate
Catalog No.:BCC4707
CAS No.:1811-28-5
- 5,7-Dihydroxy-3',4',5'-trimethoxyflavone
Catalog No.:BCN6807
CAS No.:18103-42-9
- Corymbosin
Catalog No.:BCN6812
CAS No.:18103-41-8
- Curcumaromin C
Catalog No.:BCN7418
CAS No.:1810034-40-2
- Isonemerosin
Catalog No.:BCN6550
CAS No.:181524-79-8
- tert-Butyldimethylsilyl Chloride
Catalog No.:BCC2796
CAS No.:18162-48-6
- SB 228357
Catalog No.:BCC7036
CAS No.:181629-93-6
- Valdecoxib
Catalog No.:BCC4441
CAS No.:181695-72-7
- Interiotherins A
Catalog No.:BCN3093
CAS No.:181701-06-4
- Cyclopiazonic acid
Catalog No.:BCC6981
CAS No.:18172-33-3
- (-)-beta-Pinene
Catalog No.:BCN3857
CAS No.:18172-67-3
- 25-Anhydrocimigenol 3-O-beta-D-xyloside
Catalog No.:BCN3436
CAS No.:181765-11-7
- Crotonoside
Catalog No.:BCN6281
CAS No.:1818-71-9
- KC 12291 hydrochloride
Catalog No.:BCC7618
CAS No.:181936-98-1
- DLPC
Catalog No.:BCC7929
CAS No.:18194-25-7
- Sequirin C
Catalog No.:BCN4688
CAS No.:18194-29-1
Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma.[Pubmed:28380458]
Oncotarget. 2017 Jun 13;8(24):39001-39011.
Nasopharyngeal carcinoma (NPC) carries a high potential for metastasis and immune escape, with a great risk of relapse after primary treatment. Through analysis of whole genome expression profiling data in NPC samples, we found that the expression of a long non-coding RNA (lncRNA), actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), is significantly correlated with the immune escape marker programmed death 1 (PD-1). We therefore assessed the expression of AFAP1-AS1 and PD-1 in a cohort of 96 paraffin-embedded NPC samples and confirmed that AFAP1-AS1 and PD-1 are co-expressed in infiltrating lymphocytes in NPC tissue. Moreover, patients with high expression of AFAP1-AS1 or PD-1 in infiltrating lymphocytes were more prone to distant metastasis, and NPC patients with positive expression of both AFAP1-AS1 and PD-1 had the poorest prognosis. This study suggests that AFAP1-AS1 and PD-1 may be potential therapeutic targets in NPC and that patients with co-expression of AFAP1-AS1 and PD-1 may be ideal candidates for future clinical trials of anti-PD-1 immune therapy.
Mechanistic insight into the regioselectivity of Pd(ii)-catalyzed C-H functionalization of N-methoxy cinnamamide.[Pubmed:28379232]
Dalton Trans. 2017 Apr 19;46(16):5288-5296.
Computational studies have been applied to gain insight into the mechanism of Pd(ii) catalyzed alpha-C-H functionalization of N-methoxy cinnamamide. The results show that the whole catalytic cycle proceeds via sequential six steps, including (i) catalyst Pd(t-BuNC)2 oxidation with O2, (ii) O-H deprotonation, (iii) t-BuNC migratory insertion to the Pd-C bond, (iv) acyl migration, (v) C-H activation and (vi) reductive elimination. The regioselectivity for different C-H activation sites depends on the coordination structures of alpha-C or beta-C to the palladium(ii) center. The coordination of alpha-C to the palladium(ii) center shows a regular planar quadrilateral structure, which is stable. However, the beta-C coordinating to the palladium(ii) center mainly exhibits a distorted quadrilateral structure, which is relatively unstable. Thus, the barrier of alpha-C-H activation is much lower than that of beta-C-H activation. The present results provide a deep understanding of the site-selectivity of C-H activation.
Three 1D cyanide-bridged M(Ni, Pd, Pt)-Mn(II) Coordination Polymer: Synthesis, Crystal Structure and Magnetic Properties.[Pubmed:28380238]
Acta Chim Slov. 2017 Mac;64(1):215-220.
Three tetracyanide-containing building blocks K2[M(CN)4] (M = Ni, Pd, Pt) and one semi-closed macrocycle seven-coordinated manganese(II) compound have been employed to assemble cyanide-bridged heterometallic complexes, resulting in three cyanide-bridged MII-MnII complexes: [Mn(L)][Ni(CN)4] . 2H2O (1) [Mn(L)][Pd(CN)4] (2) and [Mn(L)][Pt(CN)4] (3) (L = 2,6-bis[1-(2-(N-methylamino)ethylimino)ethyl]pyridine). Single-crystal X-ray diffraction analysis shows their similar one-dimensional structure consisting of the alternating [Mn(L)]2+ species and [M(CN)4]2- building blocks, generating a cyanide-bridged neutral polymeric chain. In all three isostructural complexes the coordination geometry of manganese ion is a slightly distorted pentagonal-bipyramidal with the two cyanide nitrogen atoms at the trans positions and N5 coordinating mode at the equatorial plane from ligand L. Investigation over magnetic properties of these complexes reveals very weak antiferromagnetic interaction between neighboring Mn(II) ions bridged by the long NC-M-CN unit. A best-fit to the magnetic susceptibility of complexes 1-3 leads to the magnetic coupling constant of J = -0.081, -0.103 and -0.14 cm-1, respectively.
Pd-Catalyzed Autotandem Reactions with N-Tosylhydrazones. Synthesis of Condensed Carbo- and Heterocycles by Formation of a C-C Single Bond and a C horizontal lineC Double Bond on the Same Carbon Atom.[Pubmed:28379703]
Org Lett. 2017 Apr 21;19(8):2034-2037.
A new Pd-catalyzed autotandem reaction is introduced that consists of the cross-coupling of a benzyl bromide with a N-tosylhydrazone followed by an intramolecular Heck reaction with an aryl bromide. During the process, a single and a double C-C bond are formed on the same carbon atom. Two different arrangements for the reactive functional groups are possible, rendering great flexibility to the transformation. The same strategy led to 9-methylene-9H-fluorenes, 9-methylene-9H-xanthenes, 9-methylene-9,10-dihydroacridines, and also dihydropyrroloisoquinoline and dihydroindoloisoquinoline derivatives.