Interiotherins ACAS# 181701-06-4 |
Quality Control & MSDS
3D structure
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| Cas No. | 181701-06-4 | SDF | Download SDF |
| PubChem ID | 177359 | Appearance | Cryst. |
| Formula | C29H28O8 | M.Wt | 504.5 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1CC2=CC3=C(C(=C2C4=C(C5=C(C=C4C(C1C)OC(=O)C6=CC=CC=C6)OCO5)OC)OC)OCO3 | ||
| Standard InChIKey | MBGKPRSARHEFAG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C29H28O8/c1-15-10-18-11-20-25(35-13-33-20)27(31-3)22(18)23-19(12-21-26(28(23)32-4)36-14-34-21)24(16(15)2)37-29(30)17-8-6-5-7-9-17/h5-9,11-12,15-16,24H,10,13-14H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL. |
| Targets | HIV |
Interiotherins A Dilution Calculator
Interiotherins A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9822 mL | 9.9108 mL | 19.8216 mL | 39.6432 mL | 49.554 mL |
| 5 mM | 0.3964 mL | 1.9822 mL | 3.9643 mL | 7.9286 mL | 9.9108 mL |
| 10 mM | 0.1982 mL | 0.9911 mL | 1.9822 mL | 3.9643 mL | 4.9554 mL |
| 50 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.7929 mL | 0.9911 mL |
| 100 mM | 0.0198 mL | 0.0991 mL | 0.1982 mL | 0.3964 mL | 0.4955 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Chemical constituents of petroleum ether extract of fruits of Schisandra sphenanthera].[Pubmed:22993989]
Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1597-601.
OBJECTIVE: To study the chemical constituents in the fruits of Schisandra sphenanthera. METHOD: The constituents were isolated by their silica gel column, Sephadex LH-20 gel column, and their structures were elucidated by their chemical properties and spectroscopic analyses. RESULT: Twelve compounds were isolated and identified as (+)-anwulignan (1), deoxyschizandrin (2), interiotherin A (3), schisantherin A (4), beta-sitosterol (5), schisantherin D (6), 4-hydroxybenzaldehyde (7), 6-O-benzoylgomisin O (8), schizandronic acid (9), schisanlactone D (10), schisanlactone B (11), kadsulactone A (12). CONCLUSION: Compounds 3, 7, 10-12 were obtained from this plant for the first time.
Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.[Pubmed:8946749]
J Nat Prod. 1996 Nov;59(11):1066-8.
Two new lignans, Interiotherins A (1) and B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data. Compounds 1 and 4 inhibit HIV replication with EC50 values of 3.1 and 0.5 micrograms/mL, respectively.
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent.
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