Almotriptan Malate5-HT1B/1D-receptor agonist CAS# 181183-52-8 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 181183-52-8 | SDF | Download SDF |
| PubChem ID | 123607 | Appearance | Powder |
| Formula | C21H31N3O7S | M.Wt | 469.55 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 94 mg/mL (200.19 mM) in DMSO | ||
| Chemical Name | N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine;2-hydroxybutanedioic acid | ||
| SMILES | CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3.C(C(C(=O)O)O)C(=O)O | ||
| Standard InChIKey | QHATUKWEVNMHRY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Almotriptan Malate Dilution Calculator
Almotriptan Malate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1297 mL | 10.6485 mL | 21.297 mL | 42.594 mL | 53.2425 mL |
| 5 mM | 0.4259 mL | 2.1297 mL | 4.2594 mL | 8.5188 mL | 10.6485 mL |
| 10 mM | 0.213 mL | 1.0648 mL | 2.1297 mL | 4.2594 mL | 5.3242 mL |
| 50 mM | 0.0426 mL | 0.213 mL | 0.4259 mL | 0.8519 mL | 1.0648 mL |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.213 mL | 0.4259 mL | 0.5324 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults. Almotriptan showed low nanomolar affin
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High performance liquid chromatographic analysis of almotriptan malate in bulk and tablets.[Pubmed:24312833]
Adv Pharm Bull. 2013;3(1):183-8.
PURPOSE: A simple RP-HPLC method has been developed and validated for the determination of Almotriptan Malate (ATM) in bulk and tablets. METHODS: Chromatographic separation of ATM was achieved by using a Thermo Scientific C18 column. A Mobile phase containing a mixture of methanol, water and acetic acid (4:8:0.1 v/v) was pumped at the flow rate of 1 mL/min. Detection was performed at 227 nm. According to ICH guidelines, the method was validated. RESULTS: The calibration curve was linear in the concentration range 5-60 microg/mL for the ATM with regression coefficient 0.9999. The method was precise with RSD <1.2%. Excellent recoveries of 99.60 - 100.80% proved the accuracy of the method. The limits of detection and quantification were found to be 0.025 and 0.075 microg/mL, respectively. CONCLUSION: The method was successfully applied for the quantification of ATM in tablets with acceptable accuracy and precision.
A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate API.[Pubmed:18191357]
J Pharm Biomed Anal. 2008 Mar 13;46(4):792-8.
An isocratic reversed phase liquid chromatographic (RP-LC) method has been developed and subsequently validated for the determination of Almotriptan Malate and its process-related impurities. Separation was achieved with a Phenomenex, Gemini, C-18 column and sodium phosphate buffer (pH adjusted to 7.6): acetonitrile (80:20, v/v) as eluent, at a flow rate of 1.5 mL/min. UV detection was performed at 227 nm. The method is simple, rapid, selective, accurate and stability indicating. The described method is linear over a range of LOQ, 1.5 ug/mL (150% of the specification limit) for all the process-related impurities. The method precision for the determination of related compounds was below 1.0% R.S.D. The accuracy of the method demonstrated at 4 levels in the range of 25-150% of the specification limit and the recovery of impurities were found to be in the range of 96-102%. The method is useful in the quality control of bulk manufacturing.
Almotriptan, an antimigraine agent, and its malate salt.[Pubmed:18216450]
Acta Crystallogr C. 2008 Jan;64(Pt 1):o15-7.
The crystal structures of almotriptan {systematic name: N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine}, C17H25N3O2S, and Almotriptan Malate {systematic name: N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanaminium malate, C17H26N3O2S+ x C4H5O5(-), a novel selective serotonin 1B/D agonist, have been determined in order to gain further insight into the structure-activity relationships of triptans. The two structures differ in the orientation of their sulfonylpyrrolidine side chains. A comparison with other triptans reveals that molecules of almotriptan, sumatriptan, zolmitriptan and rizatriptan can adopt two principal conformations. N-H...N, N-H...O and O-H...O hydrogen bonds are responsible for the molecular packing.
Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form.[Pubmed:21694997]
Indian J Pharm Sci. 2010 Sep;72(5):629-32.
A new, simple, precise and accurate high performance thin layer chromatographic method has been proposed for the determination of Almotriptan Malate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 GF(254) with butanol:acetic acid:water (3:1:1) was used as mobilephase. Quantitative analysis was performed by densitometric scanning at 300 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range of 100-700 ng/band for Almotriptan Malate. The method was successfully applied to the analysis of drug in a pharmaceutical dosage form.
