tert-Butyldimethylsilyl ChlorideCAS# 18162-48-6 |
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| Cas No. | 18162-48-6 | SDF | Download SDF |
| PubChem ID | 28928 | Appearance | Powder |
| Formula | C6H15ClSi | M.Wt | 150.7 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in water or 1% acetic acid | ||
| Chemical Name | tert-butyl-chloro-dimethylsilane | ||
| SMILES | CC(C)(C)[Si](C)(C)Cl | ||
| Standard InChIKey | BCNZYOJHNLTNEZ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
tert-Butyldimethylsilyl Chloride Dilution Calculator
tert-Butyldimethylsilyl Chloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.6357 mL | 33.1785 mL | 66.357 mL | 132.714 mL | 165.8925 mL |
| 5 mM | 1.3271 mL | 6.6357 mL | 13.2714 mL | 26.5428 mL | 33.1785 mL |
| 10 mM | 0.6636 mL | 3.3179 mL | 6.6357 mL | 13.2714 mL | 16.5893 mL |
| 50 mM | 0.1327 mL | 0.6636 mL | 1.3271 mL | 2.6543 mL | 3.3179 mL |
| 100 mM | 0.0664 mL | 0.3318 mL | 0.6636 mL | 1.3271 mL | 1.6589 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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tert-Butyldimethylsilyl Chloride
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Synthesis and structure-activity relationship of 3-O-acylated (-)-epigallocatechins as 5alpha-reductase inhibitors.[Pubmed:21044810]
Eur J Med Chem. 2010 Dec;45(12):6068-76.
A series of 3-O-acylated (-)-epigallocatechins were synthesized and their inhibition of steroid 5alpha-reductase was studied. They were prepared from the reaction of EGCG with tert-Butyldimethylsilyl Chloride followed by reductive cleavage of the ester bond. The resultant (-)-epigallocatechins penta-O-tert-butyldimethylsilyl ether was esterified with different fatty acids then desilylated to provide the corresponding products. The activity of 3-O-acylated (-)-epigallocatechins increased with the increasing carbon numbers of the fatty acid moiety, reaching maximum for 16 carbon atoms (compound 4h) with an IC50 of 0.53 muM, which was approximately 12-fold more potent than EGCG (IC50=6.29 muM). Introduction of monounsaturated fatty acid provided the most potent compound 6 (IC50=0.48 muM), which showed moderate anti-tumor activity in vivo.
Hydrogen-bonding network of N,N'-bis[2-(tert-butyldimethylsiloxy)ethyl]ethylenediammonium dichloride.[Pubmed:23832044]
Acta Crystallogr C. 2013 Jul;69(Pt 7):787-9.
The title salt, C18H46N2O2Si2(2+).2Cl(-), has been synthesized by reaction of N,N'-bis(2-hydroxyethyl)ethylenediamine with tert-Butyldimethylsilyl Chloride. The zigzag backbone dication is located across an inversion centre and the two chloride anions are related by inversion symmetry. The ionic components form a supramolecular two-dimensional network via N-H...Cl hydrogen bonding, which is responsible for the high melting point compared with the oily compound N,N'-bis[2-(tert-butyldimethylsiloxy)ethyl]ethylenediamine.
A ratiometric fluorescent probe for fluoride ion employing the excited-state intramolecular proton transfer.[Pubmed:19782196]
Talanta. 2009 Nov 15;80(1):92-7.
A ratiometric fluorescent probe 1 for fluoride ion was developed based on modulation of the excited-state intramolecular proton transfer (ESIPT) process of 2-(2'-hydroxyphenyl)benzimidazole (HPBI) through the hydroxyl group protection/deprotection reaction. The probe 1 was readily prepared by the reaction of HPBI with tert-Butyldimethylsilyl Chloride (TBS-Cl) and shows only fluorescence emission maximum at 360 nm. Upon treatment with fluoride in aqueous DMF solution, the TBS protective group of probe 1 was removed readily and ESIPT of the probe was switched on, which resulted in a decrease of the emission band at 360 nm and an increase of a new fluorescence peak around 454 nm. The fluorescent intensity ratio at 454 and 360 nm (I(454)/I(360)) increases linearly with fluoride ion concentration in the range 0.3-8.0 micromol L(-1) and the detection limit is 0.19 micromol L(-1). The proposed probe shows excellent selectivity toward fluoride ion over other common anions. The method has been successfully applied to the fluoride determination in toothpaste and tap water samples.
A practical Delta 1-dehydrogenation of Delta 4-3-keto-steroids with DDQ in the presence of TBDMSCl at room temperature.[Pubmed:20226803]
Steroids. 2010 Jul;75(7):513-6.
A mild and efficient Delta(1)-dehydrogenation of Delta(4)-3-keto-steroids with DDQ in the presence of tertbutyldimethylchlorosilane at room temperature was developed.
Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood.[Pubmed:25238568]
J Pharm Biomed Anal. 2015 Jan;102:25-32.
A sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of levetiracetam and lamotrigine in whole blood. A solid-phase extraction (SPE) procedure using HF Bond Elut C18 columns followed by derivatization using N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide (MTBSTFA) with 1% tert-Butyldimethylsilyl Chloride (TBDMSCl) was used. In this assay, levetiracetam-d6 was used as internal standard. Limits of detection and quantification were 0.15 and 0.50 mug/mL, respectively, for both analytes. The method was proved to be linear within the concentration range of 0.50-50.0 mug/mL (R(2) >/= 0.992) for both analytes. Absolute recovery was found to be at least 90.0 and 97.2% for levetiracetam and lamotrigine, respectively. Intra-day and inter-day accuracy values for both analytes were ranged from -6.5 to 4.2 and -6.6 to 3.0%, respectively, whereas their respective precision values were less than 11.4 and 8.3%. The developed method was successfully used in our laboratory for quantification of levetiracetam and lamotrigine blood concentrations during the investigation of forensic cases where these antiepileptic drugs were involved. This method could also be used for therapeutic drug monitoring purposes.
