NeuchromeninCAS# 180964-26-5 |
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| Cas No. | 180964-26-5 | SDF | Download SDF |
| PubChem ID | 10729197 | Appearance | Powder |
| Formula | C13H12O5 | M.Wt | 248.23 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S)-8,9-dihydroxy-2-methyl-3,5-dihydro-2H-pyrano[3,2-c]chromen-4-one | ||
| SMILES | CC1CC(=O)C2=C(O1)C3=CC(=C(C=C3OC2)O)O | ||
| Standard InChIKey | SGTSJAOFFFAYJH-LURJTMIESA-N | ||
| Standard InChI | InChI=1S/C13H12O5/c1-6-2-9(14)8-5-17-12-4-11(16)10(15)3-7(12)13(8)18-6/h3-4,6,15-16H,2,5H2,1H3/t6-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. (-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml. |
Neuchromenin Dilution Calculator
Neuchromenin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0285 mL | 20.1426 mL | 40.2852 mL | 80.5704 mL | 100.713 mL |
| 5 mM | 0.8057 mL | 4.0285 mL | 8.057 mL | 16.1141 mL | 20.1426 mL |
| 10 mM | 0.4029 mL | 2.0143 mL | 4.0285 mL | 8.057 mL | 10.0713 mL |
| 50 mM | 0.0806 mL | 0.4029 mL | 0.8057 mL | 1.6114 mL | 2.0143 mL |
| 100 mM | 0.0403 mL | 0.2014 mL | 0.4029 mL | 0.8057 mL | 1.0071 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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84(P-41) Determination of the Absolute Configuration of Microbial Metabolites, (-)-Neuchromenin, (-)-Nocardione A and (-)-Nocardione B by Their Synthesis
Natural Organic Compounds Symposium keynote speech (43), 2001: 497-502.
In 1996 (-)-Neuchromenin (1) was isolated from the culture broth of Eupenicillium javanicum var. meloforme PF1181 as an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 μg/ml. Its structure was deduced as 1 by extensive spectral analysis, although its absolute configuration remained unknown. In order to settle that stereochemical problem, we undertook the synthesis of both the enantiomers of Neuchromenin using both the enantiomers of known aldehyde (11). By synthesizing both (R) and (S) enantiomers of Neuchromenin, we found (S) enantiomer to be identical with the naturally occurring (-)-Neuchromenin. In 2000 two new furano-o-naphthoquinones, (-)-nocardione B (2) and (-)-nocardione A (3) were isolated as new tyrosine phosphatase inhibitors with moderate antifungal and cytotoxic activities. Due to the scarcity of the materials, their absolute configuration remained unknown. In order to solve this problem, we undertook a synthesis of optically active nocardiones with known absolute configuration. (R)-(+)-Nocardione B (2) and (S)-(-)-nocardione A (3) were synthesized by starting from the commercially available enantiomers of propylene oxide and 5-benzyloxy (or methoxy)-1-tetralone. As a result, the absolute configuration of the naturally occurring (-)-nocardione A and (-)-nocardione B was established as S.
