Cyclo(Pro-Trp)CAS# 67889-75-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 67889-75-2 | SDF | Download SDF |
PubChem ID | 102004914 | Appearance | Powder |
Formula | C16H17N3O2 | M.Wt | 283.33 |
Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 3-(1H-indol-2-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione | ||
SMILES | C1CC2C(=O)NC(C(=O)N2C1)CC3=CC4=CC=CC=C4N3 | ||
Standard InChIKey | OAUYQLJZHZRZSL-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C16H17N3O2/c20-15-14-6-3-7-19(14)16(21)13(18-15)9-11-8-10-4-1-2-5-12(10)17-11/h1-2,4-5,8,13-14,17H,3,6-7,9H2,(H,18,20) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties. |
Targets | Antifection |
In vitro | Antimicrobial activity of selected cyclic dipeptides.[Pubmed: 10563376]Pharmazie. 1999 Oct;54(10):772-5.Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the effects of these cyclic dipeptides on the gastrointestinal epithelium in vitro. Furthermore, a relevant solvent for the possible pharmaceutical application of the products was sought concurrently.
|
Cyclo(Pro-Trp) Dilution Calculator
Cyclo(Pro-Trp) Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.5295 mL | 17.6473 mL | 35.2945 mL | 70.5891 mL | 88.2363 mL |
5 mM | 0.7059 mL | 3.5295 mL | 7.0589 mL | 14.1178 mL | 17.6473 mL |
10 mM | 0.3529 mL | 1.7647 mL | 3.5295 mL | 7.0589 mL | 8.8236 mL |
50 mM | 0.0706 mL | 0.3529 mL | 0.7059 mL | 1.4118 mL | 1.7647 mL |
100 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.7059 mL | 0.8824 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Gigantol
Catalog No.:BCN8382
CAS No.:67884-30-4
- n-Butyl-β-D-fructopyranoside
Catalog No.:BCC9097
CAS No.:67884-27-9
- Martynoside
Catalog No.:BCN4236
CAS No.:67884-12-2
- Deapi-platycodin D3
Catalog No.:BCN3240
CAS No.:67884-05-3
- Glycosolone
Catalog No.:BCN6521
CAS No.:67879-81-6
- Caftaric acid
Catalog No.:BCN2096
CAS No.:67879-58-7
- Boc-Nva-OH.DCHA
Catalog No.:BCC2642
CAS No.:67861-96-5
- Taraxasterone
Catalog No.:BCN7746
CAS No.:6786-16-9
- Ethyl 2,4-dihydroxyphenylacetate
Catalog No.:BCN4235
CAS No.:67828-62-0
- Methyl 2,4-dihydroxyphenylacetate
Catalog No.:BCN6801
CAS No.:67828-42-6
- 2,3,2'',3''-Tetrahydroochnaflavone
Catalog No.:BCN4234
CAS No.:678138-59-5
- MRK 560
Catalog No.:BCC2345
CAS No.:677772-84-8
- Scutebarbatine K
Catalog No.:BCN3223
CAS No.:960302-86-7
- Ambrox
Catalog No.:BCN6907
CAS No.:6790-58-5
- Aluminum n-octacosoxide
Catalog No.:BCC8099
CAS No.:67905-27-5
- Dehydroevodiamine
Catalog No.:BCN2974
CAS No.:67909-49-3
- Homobaldrinal
Catalog No.:BCN2681
CAS No.:67910-07-0
- Macusine B
Catalog No.:BCN6471
CAS No.:6792-07-0
- Mesaconine
Catalog No.:BCC8339
CAS No.:6792-09-2
- 1,6-Dihydro-4,7'-epoxy-1-methoxy-3',4'-methylenedioxy-6-oxo-3,8'-lignan
Catalog No.:BCN6584
CAS No.:67920-48-3
- Sodium Danshensu
Catalog No.:BCN5952
CAS No.:67920-52-9
- Aurantio-obtusin
Catalog No.:BCN1222
CAS No.:67979-25-3
- N-(5,8,11,14-Eicosatetraenoyl)taurine
Catalog No.:BCN1755
CAS No.:679834-28-7
- N-(15-Methyl-9-hexadecenoyl)taurine
Catalog No.:BCN1754
CAS No.:679834-30-1
Antimicrobial activity of selected cyclic dipeptides.[Pubmed:10563376]
Pharmazie. 1999 Oct;54(10):772-5.
Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the effects of these cyclic dipeptides on the gastrointestinal epithelium in vitro. Furthermore, a relevant solvent for the possible pharmaceutical application of the products was sought concurrently. The antimicrobial effect of the cyclic dipeptides was assayed using the Kirby-Bauer disc diffusion assay against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis, Streptococcus pneumoniae, Candida albicans, Aspergillus niger and Penicillium notatum. The effect of the cyclic dipeptides on the gastrointestinal epithelium was assessed by changes in alkaline phosphatase expression of HT-29 cells. Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties and cyclo(Trp-Pro) and cyclo(Trp-Trp) show broad spectrum antifungal properties. The maturation of the gastrointestinal cells was enhanced by cyclo(Phe-Pro), cyclo(Tyr-Pro), cyclo(Trp-Trp) and cyclo(Trp-Pro). The activity of these cyclic dipeptides thus indicates potential application of these compounds as pharmacological agents.