Cyclo(Pro-Trp)

CAS# 67889-75-2

Cyclo(Pro-Trp)

Catalog No. BCN2422----Order now to get a substantial discount!

Product Name & Size Price Stock
Cyclo(Pro-Trp): 5mg $184 In Stock
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Quality Control of Cyclo(Pro-Trp)

Number of papers citing our products

Chemical structure

Cyclo(Pro-Trp)

3D structure

Chemical Properties of Cyclo(Pro-Trp)

Cas No. 67889-75-2 SDF Download SDF
PubChem ID 102004914 Appearance Powder
Formula C16H17N3O2 M.Wt 283.33
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-(1H-indol-2-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
SMILES C1CC2C(=O)NC(C(=O)N2C1)CC3=CC4=CC=CC=C4N3
Standard InChIKey OAUYQLJZHZRZSL-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H17N3O2/c20-15-14-6-3-7-19(14)16(21)13(18-15)9-11-8-10-4-1-2-5-12(10)17-11/h1-2,4-5,8,13-14,17H,3,6-7,9H2,(H,18,20)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cyclo(Pro-Trp)

The Pantoea agglomerans

Biological Activity of Cyclo(Pro-Trp)

DescriptionCyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties.
TargetsAntifection
In vitro

Antimicrobial activity of selected cyclic dipeptides.[Pubmed: 10563376]

Pharmazie. 1999 Oct;54(10):772-5.

Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the effects of these cyclic dipeptides on the gastrointestinal epithelium in vitro. Furthermore, a relevant solvent for the possible pharmaceutical application of the products was sought concurrently.
METHODS AND RESULTS:
The antimicrobial effect of the cyclic dipeptides was assayed using the Kirby-Bauer disc diffusion assay against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis, Streptococcus pneumoniae, Candida albicans, Aspergillus niger and Penicillium notatum. The effect of the cyclic dipeptides on the gastrointestinal epithelium was assessed by changes in alkaline phosphatase expression of HT-29 cells. Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties and cyclo(Trp-Pro) and cyclo(Trp-Trp) show broad spectrum antifungal properties. The maturation of the gastrointestinal cells was enhanced by cyclo(Phe-Pro), cyclo(Tyr-Pro), cyclo(Trp-Trp) and cyclo(Trp-Pro).
CONCLUSIONS:
The activity of these cyclic dipeptides thus indicates potential application of these compounds as pharmacological agents.

Cyclo(Pro-Trp) Dilution Calculator

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Cyclo(Pro-Trp) Molarity Calculator

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Preparing Stock Solutions of Cyclo(Pro-Trp)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5295 mL 17.6473 mL 35.2945 mL 70.5891 mL 88.2363 mL
5 mM 0.7059 mL 3.5295 mL 7.0589 mL 14.1178 mL 17.6473 mL
10 mM 0.3529 mL 1.7647 mL 3.5295 mL 7.0589 mL 8.8236 mL
50 mM 0.0706 mL 0.3529 mL 0.7059 mL 1.4118 mL 1.7647 mL
100 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.7059 mL 0.8824 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cyclo(Pro-Trp)

Antimicrobial activity of selected cyclic dipeptides.[Pubmed:10563376]

Pharmazie. 1999 Oct;54(10):772-5.

Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the effects of these cyclic dipeptides on the gastrointestinal epithelium in vitro. Furthermore, a relevant solvent for the possible pharmaceutical application of the products was sought concurrently. The antimicrobial effect of the cyclic dipeptides was assayed using the Kirby-Bauer disc diffusion assay against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis, Streptococcus pneumoniae, Candida albicans, Aspergillus niger and Penicillium notatum. The effect of the cyclic dipeptides on the gastrointestinal epithelium was assessed by changes in alkaline phosphatase expression of HT-29 cells. Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties and cyclo(Trp-Pro) and cyclo(Trp-Trp) show broad spectrum antifungal properties. The maturation of the gastrointestinal cells was enhanced by cyclo(Phe-Pro), cyclo(Tyr-Pro), cyclo(Trp-Trp) and cyclo(Trp-Pro). The activity of these cyclic dipeptides thus indicates potential application of these compounds as pharmacological agents.

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