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Mesaconine

CAS# 6792-09-2

Mesaconine

Catalog No. BCC8339----Order now to get a substantial discount!

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Mesaconine: 5mg $322 In Stock
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Quality Control of Mesaconine

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Chemical structure

Mesaconine

3D structure

Chemical Properties of Mesaconine

Cas No. 6792-09-2 SDF Download SDF
PubChem ID 76189547 Appearance Powder
Formula C24H39NO9 M.Wt 485.6
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6O)(C(C5O)OC)O)O)OC)OC)O)COC
Standard InChIKey GQRPJUIKGLHLLN-UHFFFAOYSA-N
Standard InChI InChI=1S/C24H39NO9/c1-25-8-21(9-31-2)11(26)6-12(32-3)23-10-7-22(29)18(27)13(10)24(30,19(28)20(22)34-5)14(17(23)25)15(33-4)16(21)23/h10-20,26-30H,6-9H2,1-5H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Mesaconine

The branch root of Aconitum carmichaeli Debx.

Biological Activity of Mesaconine

Description1. Mesaconine has cardiac effect. 2. Mesaconine has anti-NF-κB activity. 3. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and immune suppression.
TargetsIL Receptor | NF-kB | IkB | Immunology & Inflammation related | IKK

Mesaconine Dilution Calculator

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Mesaconine Molarity Calculator

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Preparing Stock Solutions of Mesaconine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0593 mL 10.2965 mL 20.5931 mL 41.1862 mL 51.4827 mL
5 mM 0.4119 mL 2.0593 mL 4.1186 mL 8.2372 mL 10.2965 mL
10 mM 0.2059 mL 1.0297 mL 2.0593 mL 4.1186 mL 5.1483 mL
50 mM 0.0412 mL 0.2059 mL 0.4119 mL 0.8237 mL 1.0297 mL
100 mM 0.0206 mL 0.103 mL 0.2059 mL 0.4119 mL 0.5148 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Mesaconine

The in vivo pharmacokinetics, tissue distribution and excretion investigation of mesaconine in rats and its in vitro intestinal absorption study using UPLC-MS/MS.[Pubmed:29228872]

Xenobiotica. 2019 Jan;49(1):71-79.

1. Mesaconine, an ingredient from Aconitum carmichaelii Debx., has been proven to have cardiac effect. For further development and better pharmacological elucidation, the in vivo process and intestinal absorptive behavior of Mesaconine should be investigated comprehensively. 2. An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitation of Mesaconine in rat plasma, tissue homogenates, urine and feces to investigate the in vivo pharmacokinetic profiles, tissue distribution and excretion. The intestinal absorptive behavior of Mesaconine was investigated using in vitro everted rat gut sac model. 3. Mesaconine was well distributed in tissues and a mass of unchanged form was detected in feces. It was difficultly absorbed into blood circulatory system after oral administration. The insufficient oral bioavailability of Mesaconine may be mainly attributed to its low intestinal permeability due to a lack of lipophilicity. The absorption of Mesaconine in rat's intestine is a first-order process with the passive diffusion mechanism.

Description

Mesaconinean, an ingredient from Aconitum carmichaelii Debx., has cardiac effect.

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