MesaconineCAS# 6792-09-2 |
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| Cas No. | 6792-09-2 | SDF | Download SDF |
| PubChem ID | 76189547 | Appearance | Powder |
| Formula | C24H39NO9 | M.Wt | 485.6 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6O)(C(C5O)OC)O)O)OC)OC)O)COC | ||
| Standard InChIKey | GQRPJUIKGLHLLN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C24H39NO9/c1-25-8-21(9-31-2)11(26)6-12(32-3)23-10-7-22(29)18(27)13(10)24(30,19(28)20(22)34-5)14(17(23)25)15(33-4)16(21)23/h10-20,26-30H,6-9H2,1-5H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The branch root of Aconitum carmichaeli Debx.
| Description | 1. Mesaconine has cardiac effect. 2. Mesaconine has anti-NF-κB activity. 3. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and immune suppression. |
| Targets | IL Receptor | NF-kB | IkB | Immunology & Inflammation related | IKK |
Mesaconine Dilution Calculator
Mesaconine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0593 mL | 10.2965 mL | 20.5931 mL | 41.1862 mL | 51.4827 mL |
| 5 mM | 0.4119 mL | 2.0593 mL | 4.1186 mL | 8.2372 mL | 10.2965 mL |
| 10 mM | 0.2059 mL | 1.0297 mL | 2.0593 mL | 4.1186 mL | 5.1483 mL |
| 50 mM | 0.0412 mL | 0.2059 mL | 0.4119 mL | 0.8237 mL | 1.0297 mL |
| 100 mM | 0.0206 mL | 0.103 mL | 0.2059 mL | 0.4119 mL | 0.5148 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The in vivo pharmacokinetics, tissue distribution and excretion investigation of mesaconine in rats and its in vitro intestinal absorption study using UPLC-MS/MS.[Pubmed:29228872]
Xenobiotica. 2019 Jan;49(1):71-79.
1. Mesaconine, an ingredient from Aconitum carmichaelii Debx., has been proven to have cardiac effect. For further development and better pharmacological elucidation, the in vivo process and intestinal absorptive behavior of Mesaconine should be investigated comprehensively. 2. An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitation of Mesaconine in rat plasma, tissue homogenates, urine and feces to investigate the in vivo pharmacokinetic profiles, tissue distribution and excretion. The intestinal absorptive behavior of Mesaconine was investigated using in vitro everted rat gut sac model. 3. Mesaconine was well distributed in tissues and a mass of unchanged form was detected in feces. It was difficultly absorbed into blood circulatory system after oral administration. The insufficient oral bioavailability of Mesaconine may be mainly attributed to its low intestinal permeability due to a lack of lipophilicity. The absorption of Mesaconine in rat's intestine is a first-order process with the passive diffusion mechanism.
Mesaconinean, an ingredient from Aconitum carmichaelii Debx., has cardiac effect.
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