DebilonCAS# 26808-51-5 |
Quality Control & MSDS
3D structure
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| Cas No. | 26808-51-5 | SDF | Download SDF |
| PubChem ID | 57391584 | Appearance | Powder |
| Formula | C15H22O2 | M.Wt | 234.33 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1aR,3R,7R,7aR,7bS)-3-hydroxy-1,1,7,7a-tetramethyl-1a,2,3,6,7,7b-hexahydrocyclopropa[a]naphthalen-5-one | ||
| SMILES | CC1CC(=O)C=C2C1(C3C(C3(C)C)CC2O)C | ||
| Standard InChIKey | ALMYSFNKELLWOO-XANOUDBCSA-N | ||
| Standard InChI | InChI=1S/C15H22O2/c1-8-5-9(16)6-10-12(17)7-11-13(14(11,2)3)15(8,10)4/h6,8,11-13,17H,5,7H2,1-4H3/t8-,11-,12-,13+,15+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Nardostachys chinensis.
| Description | 1. Debilon shows cytotoxic activity against P-388 cells. |
| Targets | NO |
Debilon Dilution Calculator
Debilon Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.2675 mL | 21.3374 mL | 42.6749 mL | 85.3497 mL | 106.6872 mL |
| 5 mM | 0.8535 mL | 4.2675 mL | 8.535 mL | 17.0699 mL | 21.3374 mL |
| 10 mM | 0.4267 mL | 2.1337 mL | 4.2675 mL | 8.535 mL | 10.6687 mL |
| 50 mM | 0.0853 mL | 0.4267 mL | 0.8535 mL | 1.707 mL | 2.1337 mL |
| 100 mM | 0.0427 mL | 0.2134 mL | 0.4267 mL | 0.8535 mL | 1.0669 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages.[Pubmed:22079762]
Bioorg Med Chem Lett. 2012 Jan 1;22(1):706-8.
The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), Debilon (7), 4alpha,5-dimethyl-1,3-dioxo-1,2,3,4,4alpha,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC(50) values of 4.6-21.6 muM.
Cytotoxic sesquiterpenes from Nardostachys chinensis.[Pubmed:8370115]
Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4.
Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), Debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.
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