PerivineCAS# 2673-40-7 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 2673-40-7 | SDF | Download SDF |
| PubChem ID | 6473766 | Appearance | Cryst. |
| Formula | C20H22N2O3 | M.Wt | 338.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC=C1CNC2CC3=C(C(=O)CC1C2C(=O)OC)NC4=CC=CC=C34 | ||
| Standard InChIKey | NKTORRNHKYVXSU-XXMLWKDOSA-N | ||
| Standard InChI | InChI=1S/C20H22N2O3/c1-3-11-10-21-16-8-14-12-6-4-5-7-15(12)22-19(14)17(23)9-13(11)18(16)20(24)25-2/h3-7,13,16,18,21-22H,8-10H2,1-2H3/b11-3-/t13-,16-,18-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Perivine may resolve the instability of the retinoblastoma-associated proteins (RbAp48) complex and thus be used in Alzheimer's disease therapy. 2. Perivine, vobasine, coronaridine and dichomine show hypotensive and muscle relaxant activity. |
Perivine Dilution Calculator
Perivine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9551 mL | 14.7754 mL | 29.5508 mL | 59.1017 mL | 73.8771 mL |
| 5 mM | 0.591 mL | 2.9551 mL | 5.9102 mL | 11.8203 mL | 14.7754 mL |
| 10 mM | 0.2955 mL | 1.4775 mL | 2.9551 mL | 5.9102 mL | 7.3877 mL |
| 50 mM | 0.0591 mL | 0.2955 mL | 0.591 mL | 1.182 mL | 1.4775 mL |
| 100 mM | 0.0296 mL | 0.1478 mL | 0.2955 mL | 0.591 mL | 0.7388 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Canertinib
Catalog No.:BCN2172
CAS No.:267243-28-7
- [Nphe1]Nociceptin(1-13)NH2
Catalog No.:BCC5739
CAS No.:267234-08-2
- Picraline
Catalog No.:BCN4762
CAS No.:2671-32-1
- Boc-Glycinol
Catalog No.:BCC3093
CAS No.:26690-80-2
- 6'-O-beta-D-Apiofuranosylsweroside
Catalog No.:BCN2876
CAS No.:266678-59-5
- N4-Benzoylcytosine
Catalog No.:BCC9073
CAS No.:26661-13-2
- Dipalmitin
Catalog No.:BCN2214
CAS No.:26657-95-4
- Salirepin
Catalog No.:BCN5149
CAS No.:26652-12-0
- Conodurine
Catalog No.:BCN7463
CAS No.:2665-57-8
- Reparixin L-lysine salt
Catalog No.:BCC1886
CAS No.:266359-93-7
- Reparixin
Catalog No.:BCC1885
CAS No.:266359-83-5
- Fmoc-β-Homo-Met-OH
Catalog No.:BCC2630
CAS No.:266359-48-2
- Alibendol
Catalog No.:BCC4758
CAS No.:26750-81-2
- Amoxicillin
Catalog No.:BCC4625
CAS No.:26787-78-0
- Robtein
Catalog No.:BCN4658
CAS No.:2679-65-4
- Xanthatin
Catalog No.:BCN5150
CAS No.:26791-73-1
- Dehydrodiisoeugenol
Catalog No.:BCN1240
CAS No.:2680-81-1
- Indapamide
Catalog No.:BCC4788
CAS No.:26807-65-8
- Debilon
Catalog No.:BCN7696
CAS No.:26808-51-5
- Udenafil
Catalog No.:BCC5213
CAS No.:268203-93-6
- Coronalolide methyl ester
Catalog No.:BCN5151
CAS No.:268214-50-2
- Coronalolide
Catalog No.:BCN5152
CAS No.:268214-51-3
- Coronalolic acid
Catalog No.:BCN5153
CAS No.:268214-52-4
- Harringtonine
Catalog No.:BCN6794
CAS No.:26833-85-2
Lead discovery for Alzheimer's disease related target protein RbAp48 from traditional Chinese medicine.[Pubmed:25165715]
Biomed Res Int. 2014;2014:764946.
Deficiency or loss of function of Retinoblastoma-associated proteins (RbAp48) is related with Alzheimer's disease (AD), and AD disease is associated with age-related memory loss. During normal function, RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription, but an unstable complex may affect the function of RbAp48. This study utilizes the world's largest traditional Chinese medicine (TCM) database and virtual screening to provide potential compounds for RbAp48 binding. A molecular dynamics (MD) simulation was employed to understand the variations after protein-ligand interaction. FOG1 was found to exhibit low stability after RbAp48 binding; the peptide displayed significant movement from the initial docking position, a phenomenon which matched the docking results. The protein structure of the other TCM candidates was not variable during MD simulation and had a greater stable affinity for RbAp48 binding than FOG1. Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy.
Muscle relaxant activity and hypotensive activity of some Tabernaemontana alkaloids.[Pubmed:4021514]
J Ethnopharmacol. 1985 May;13(2):165-73.
Stemmadenine, the major alkaloid from the seeds of Tabernaemontana dichotoma, showed hypotensive activity and weak muscle relaxant activity. Perivine, vobasine, coronaridine and dichomine, some of the alkaloids found in the leaves, fruits and bark of T. dichotoma, also showed hypotensive and muscle relaxant activity.
