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Demethylcarolignan E

CAS# 873694-46-3

Demethylcarolignan E

Catalog No. BCN7018----Order now to get a substantial discount!

Product Name & Size Price Stock
Demethylcarolignan E: 5mg $886 In Stock
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Quality Control of Demethylcarolignan E

Number of papers citing our products

Chemical structure

Demethylcarolignan E

3D structure

Chemical Properties of Demethylcarolignan E

Cas No. 873694-46-3 SDF Download SDF
PubChem ID 5274621 Appearance Powder
Formula C39H40O13 M.Wt 716.73
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[3-hydroxy-4-[(1S,2S)-1-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxypropan-2-yl]oxyphenyl]propyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
SMILES COC1=C(C=CC(=C1)C=CC(=O)OCCCC2=CC(=C(C=C2)OC(COC(=O)C=CC3=CC(=C(C=C3)O)OC)C(C4=CC(=C(C=C4)O)OC)O)O)O
Standard InChIKey GSGRJWMOIKUHLN-DZOJLRKVSA-N
Standard InChI InChI=1S/C39H40O13/c1-47-33-20-25(6-12-28(33)40)9-16-37(44)50-18-4-5-24-8-15-32(31(43)19-24)52-36(39(46)27-11-14-30(42)35(22-27)49-3)23-51-38(45)17-10-26-7-13-29(41)34(21-26)48-2/h6-17,19-22,36,39-43,46H,4-5,18,23H2,1-3H3/b16-9+,17-10+/t36-,39-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Demethylcarolignan E

The stems of Hibiscus taiwanensis.

Biological Activity of Demethylcarolignan E

DescriptionDemethylcarolignan E is a natural product from Hibiscus taiwanensis.
In vitro

Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis.[Pubmed: 15080919]

Bioorg Med Chem. 2004 May 1;12(9):2193-7.


METHODS AND RESULTS:
The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-Demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies.
CONCLUSIONS:
In cytotoxicity evaluation of the isolates, 9,9'-O-feruloyl-(-)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC(50) values of 1.8 and 3.9 microg/mL, respectively.

Demethylcarolignan E Dilution Calculator

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Demethylcarolignan E Molarity Calculator

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Preparing Stock Solutions of Demethylcarolignan E

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3952 mL 6.9761 mL 13.9523 mL 27.9045 mL 34.8806 mL
5 mM 0.279 mL 1.3952 mL 2.7905 mL 5.5809 mL 6.9761 mL
10 mM 0.1395 mL 0.6976 mL 1.3952 mL 2.7905 mL 3.4881 mL
50 mM 0.0279 mL 0.1395 mL 0.279 mL 0.5581 mL 0.6976 mL
100 mM 0.014 mL 0.0698 mL 0.1395 mL 0.279 mL 0.3488 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Demethylcarolignan E

Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis.[Pubmed:15080919]

Bioorg Med Chem. 2004 May 1;12(9):2193-7.

The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-Demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9'-O-feruloyl-(-)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC(50) values of 1.8 and 3.9 microg/mL, respectively.

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