Emodin-1-O-glucoside

The roots and rhizomes of Rheum palmatum L.

Comparative analyses of chromatographic fingerprints of the roots of Polygonum multiflorum Thunb. and their processed products using RRLC/DAD/ESI-MS(n).[Pubmed:21674436]

Planta Med. 2011 Nov;77(16):1855-60.

The dried roots of Polygonum multiflorum Thunb. (Heshouwu) and their processed products (Zhi-heshouwu) are widely used in traditional Chinese medicine, yet their therapeutic effects are different. Previous investigations focused mainly on the differences between Heshouwu and Zhi-heshouwu in the contents of several known compounds. In this study, a rapid resolution liquid chromatography-diode array detection/electrospray ionization tandem mass spectrometry (RRLC/DAD/ESI-MS(n)) method was developed for the comparative analysis of the components of Heshouwu and Zhi-heshouwu. A total of 23 compounds were identified or tentatively characterized. We found that 16 batches of Heshouwu and 15 batches of Zhi-heshouwu samples shared eight compounds, including gallic acid; 3,5,4'-tetrahydroxylstilbene-2,3-di-O-glucoside, CIS-2,3,5,4'-tetrahydroxylstilbene-2-O- beta-D-glucoside, trans-2,3,5,4'-tetrahydroxylstilbene-2-O- beta-D-glucoside, emodin-8-O- beta-D-glucoside, physcion-8-O- beta-D-glucoside, emodin, and physcion. Nevertheless, the relative amounts of gallic acid, emodin, and physcion were very high in Zhi-heshouwu samples compared to those in Heshouwu samples. Six compounds disappeared after processing and were unique for Heshouwu: catechin, flavanol gallate dimer, polygonimitin B, Emodin-1-O-glucoside, emodin-8-O-(6'-O-malonyl)-glucoside, and physcion-8-O-(6'-O-malonyl)-glucoside. Three compounds were unique for Zhi-heshouwu: hydroxymaltol, 2,3-dihydro-3,5-dihydroxy-6-methyl-4(H)-pyran-4-one, and 5-hydroxymethyl furfural. These results suggest that the types and relative amounts of the chemical components of Heshouwu and Zhi-heshouwu are different.

[Identification and determination of major constituents in Polygonum cuspidatum Sieb. et Zucc. by high performance liquid chromatography/electrospray ionization-ion trap-time-of-flight mass spectrometry].[Pubmed:19938497]

Se Pu. 2009 Jul;27(4):425-30.

A facile method using high performance liquid chromatography/electrospray ionization-ion trap-time-of-flight mass spectrometry (HPLC/ESI-IT-TOF MS) has been established for the analysis of multiple constituents in Polygonum cuspidatum Sieb. et Zucc. Six chemical standards including emodin, chrysophanol, physcion, rhein, aloe-emodin and polydatin were studied systematically and their fragmentation pathways were concluded. The methanol extract of Polygonum cuspidatum Sieb. et Zucc. was separated and analyzed by HPLC/ESI-QIT-TOF MS system in negative ion mode. A total of 10 constituents were identified or tentatively characterized with supporting results on the fragmentation pathways of 6 chemical standards and relative references. These constituents are mainly anthraquinones, stilbenes, torachryson and their derivatives, including resveratroloside, polydatin, emodin-8-O-glucoside, resveratrol, torachryson-8-O-glucoside, Emodin-1-O-glucoside, torachryson-8-O-(6'-acetyl)glucoside (newly discovered), physcion-8-O-glucoside, physcion-8-O-(6'-acetyl)glucoside (newly discovered) and emodin. It is an extremely simple way by using HPLC/ESI-IT-TOF MS to provide chemical information concerning the constituents in herbal medicines and making the identification results more convinced.

Chinese hamster ovary-sphingomyelin synthase2 biospecific extraction and liquid chromatography with tandem mass spectrometry analysis for the prediction of bioactive components of Rhizoma Polygoni Cuspidati.[Pubmed:26763406]

J Sep Sci. 2016 Mar;39(6):1067-72.

A novel strategy for predicting bioactive components in traditional Chinese medicines using Chinese hamster ovary-sphingomyelin synthase2 (CHO-SMS2 ) cell biospecific extraction and high-performance liquid chromatography with diode array detection and tandem mass spectrometry analysis was proposed. The hypothesis is that when cells are incubated with the extract of traditional Chinese medicines, the potential bioactive components in the traditional Chinese medicines should selectively combine with the cells, while the cell-combining components would be detectable in the extract of denatured cells. The identities of the cell-combining components could be determined by liquid chromatography with tandem mass spectrometry. Using the proposed approach, the potential bioactive components of Rhizoma Polygoni Cuspidati, a commonly used traditional Chinese medicine for atherosclerosis, were detected and identified. Eight compounds in the extract of Rhizoma Polygoni Cuspidati were detected as the components selectively combined with CHO-SMS2 cells, which is a stable cell line that highly expresses sphingomyelin synthases, it was found that piceid, resveratrol, emodin-8-beta-d-glucoside, physcion-8-beta-d-glucoside, emodin, physcion, 3,5,4'-trihydroxystilbene-3-O-(6"-galloyl)-glucoside, and Emodin-1-O-glucoside combined specifically with CHO-SMS2 cells. The results indicate that the proposed approach may be applied to predict the bioactive candidates in traditional Chinese medicines.

Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC50 of 0.85 μM.

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