Worenine

CAS# 38763-29-0

Worenine

2D Structure

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Quality Control of Worenine

3D structure

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Worenine

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Chemical Properties of Worenine

Cas No. 38763-29-0 SDF Download SDF
PubChem ID 20055073 Appearance Cryst.
Formula C20H16NO4+ M.Wt 334.11
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2C3=CC4=C(C=C3CC[N+]2=CC5=CC6=C(C=C15)OCO6)OCO4
Standard InChIKey LCXREBMNASQAOC-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H16NO4/c1-11-14-6-18-17(23-10-24-18)5-13(14)8-21-3-2-12-4-16-19(25-9-22-16)7-15(12)20(11)21/h4-8H,2-3,9-10H2,1H3/q+1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Worenine

The roots of Coptis chinensis Franch.

Worenine Dilution Calculator

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Worenine Molarity Calculator

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Preparing Stock Solutions of Worenine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.993 mL 14.9651 mL 29.9303 mL 59.8605 mL 74.8257 mL
5 mM 0.5986 mL 2.993 mL 5.9861 mL 11.9721 mL 14.9651 mL
10 mM 0.2993 mL 1.4965 mL 2.993 mL 5.9861 mL 7.4826 mL
50 mM 0.0599 mL 0.2993 mL 0.5986 mL 1.1972 mL 1.4965 mL
100 mM 0.0299 mL 0.1497 mL 0.2993 mL 0.5986 mL 0.7483 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Worenine

Characterization of metabolites of worenine in rat biological samples using liquid chromatography-tandem mass spectrometry.[Pubmed:19773142]

J Pharm Biomed Anal. 2010 Jan 5;51(1):236-43.

The in vivo and in vitro metabolites of Worenine in rat were identified or characterized using a specific and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. In vivo samples including rat urine, feces, and plasma samples were collected after ingestion of 25 mg/kg Worenine to healthy rats. The in vivo and in vitro samples were cleaned up by a solid-phase extraction procedure (C18 cartridges) and a liquid-liquid extraction procedure, respectively. Then these pretreated samples were injected into a reversed-phase C18 column with mobile phase of methanol-ammonium acetate (2mM, adjusted to pH 3.5 with formic acid) (60:40, v/v) and detected by an on-line MS/MS system. As a result, at least twenty-seven metabolites and the parent medicine were found in rat urine after ingestion of Worenine. Seven metabolites and the parent medicine were identified or characterized in rat feces. Three metabolites and the parent medicine were detected in rat plasma. One metabolite was found in the rat intestinal flora incubation mixture, and three metabolites were characterized in the homogenized liver incubation mixture. The main phase I metabolism of Worenine in rat was dehydrogenization, hydrogenation, hydroxylation, and demethylene reactions, and that of phase II was sulfation and glucuronidation.

Description

Worenine is isolated from Coptis chinensis. Worenine in rat shows dehydrogenization, hydrogenation, hydroxylation, and demethylene reactions in phase I metabolism. The phase II metabolism sulfation and glucuronidation reactions.

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