PreskimmianineCAS# 38695-41-9 |
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| Cas No. | 38695-41-9 | SDF | Download SDF |
| PubChem ID | 12305721 | Appearance | Powder |
| Formula | C17H21NO4 | M.Wt | 303.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4,7,8-trimethoxy-3-(3-methylbut-2-enyl)-1H-quinolin-2-one | ||
| SMILES | CC(=CCC1=C(C2=C(C(=C(C=C2)OC)OC)NC1=O)OC)C | ||
| Standard InChIKey | OAEZQCLAAGSHHA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H21NO4/c1-10(2)6-7-12-15(21-4)11-8-9-13(20-3)16(22-5)14(11)18-17(12)19/h6,8-9H,7H2,1-5H3,(H,18,19) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The root barks of Dictamnus dasycarpus.
| Description | 1. Preskimmianine is the biogenetic precursor of skimmianine. 2. Preskimmianine can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. |
| Targets | NO |
Preskimmianine Dilution Calculator
Preskimmianine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.296 mL | 16.4799 mL | 32.9598 mL | 65.9196 mL | 82.3995 mL |
| 5 mM | 0.6592 mL | 3.296 mL | 6.592 mL | 13.1839 mL | 16.4799 mL |
| 10 mM | 0.3296 mL | 1.648 mL | 3.296 mL | 6.592 mL | 8.2399 mL |
| 50 mM | 0.0659 mL | 0.3296 mL | 0.6592 mL | 1.3184 mL | 1.648 mL |
| 100 mM | 0.033 mL | 0.1648 mL | 0.3296 mL | 0.6592 mL | 0.824 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells.[Pubmed:21827366]
J Enzyme Inhib Med Chem. 2012 Aug;27(4):490-4.
The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1beta-hydroxy-2-(beta-D-glucopyranosyloxy)-ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, Preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), gamma-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-gamma-fagarine (9), isomaculosidine (10). The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.
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