EvodolCAS# 22318-10-1 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 22318-10-1 | SDF | Download SDF |
| PubChem ID | 185481 | Appearance | Cryst. |
| Formula | C26H28O9 | M.Wt | 484.5 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1(C2=C(C(=O)C3(C(C24COC(=O)CC4O1)CCC5(C36C(O6)C(=O)OC5C7=COC=C7)C)C)O)C | ||
| Standard InChIKey | SNGHLUWTFLYPMT-JPRNBFAHSA-N | ||
| Standard InChI | InChI=1S/C26H28O9/c1-22(2)17-16(28)18(29)24(4)13(25(17)11-32-15(27)9-14(25)34-22)5-7-23(3)19(12-6-8-31-10-12)33-21(30)20-26(23,24)35-20/h6,8,10,13-14,19-20,28H,5,7,9,11H2,1-4H3/t13-,14-,19-,20+,23-,24-,25-,26+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Evodol and limonin possess larvicidal activity against the Asian tiger mosquitoes with LC50 values of 52.22 and 32.43 ug/ml, respectively. 2. Evodol shows inhibitory activity on nitric oxide (NO) production in lipopolysaccharide -activated RAW264.7 macrophages, suggests that it may as an anti-inflammatory agent or lead compound. |
| Targets | NO |
Evodol Dilution Calculator
Evodol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.064 mL | 10.3199 mL | 20.6398 mL | 41.2797 mL | 51.5996 mL |
| 5 mM | 0.4128 mL | 2.064 mL | 4.128 mL | 8.2559 mL | 10.3199 mL |
| 10 mM | 0.2064 mL | 1.032 mL | 2.064 mL | 4.128 mL | 5.16 mL |
| 50 mM | 0.0413 mL | 0.2064 mL | 0.4128 mL | 0.8256 mL | 1.032 mL |
| 100 mM | 0.0206 mL | 0.1032 mL | 0.2064 mL | 0.4128 mL | 0.516 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae).[Pubmed:22526296]
Parasitol Res. 2012 Sep;111(3):991-6.
In recent years, uses of environment friendly and biodegradable natural insecticides of plant origin have received renewed attention as agents for vector control. During a screening program for new agrochemicals from Chinese medicinal herbs and local wild plants, the ethanol extract of Evodia rutaecarpa Hook f. et Thomas (Rutaceae) unripe fruits was found to possess larvicidal activity against the mosquitoes. The aim of this research was to determine larvicidal activity of the ethanol extract of E. rutaecarpa unripe fruits and the isolated constituents against the larvae of the Culicidae mosquito Aedes albopictus. The powder, 5 kg of the fruit material, was extracted with 30 l of 95 % ethanol, filtered, and evaporated to dryness in a rotary vacuum evaporator. The crude extract was then partitioned between methanol-water and n-hexane. The n-hexane fraction was evaporated off to given n-hexane extract. The aqueous layer was repartitioned with chloroform to provide chloroform extract after evaporation of the solvent. Further partitioning with ethyl acetate gave a residue after evaporation of the solvent. Bioactivity-directed chromatographic separation of chloroform extract on repeated silica gel columns led to the isolation of three alkaloids (evodiamine, rutaecarpine, and wuchuyuamide I) and two limonoids (Evodol and limonin). The structures of the constituent compounds were elucidated based on high-resolution electron impact mass spectrometry and nuclear magnetic resonance. Evodiamine, rutaecarpine, and wuchuyuamide I exhibited strong larvicidal activity against the early fourth instar larvae of A. albopictus with LC(50) values of 12.51, 17.02, and 26.16 mug/ml, respectively. Limonin and Evodol also possessed larvicidal activity against the Asian tiger mosquitoes with LC(50) values of 32.43 and 52.22 mug/ml, respectively, while the ethanol extract had a LC(50) value of 43.21 mug/ml. The results indicated that the ethanol extract of E. rutaecarpa and the five isolated constituents have a good potential as a source for natural larvicides.
