Grandiflorenic acidCAS# 22338-67-6 |
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| Cas No. | 22338-67-6 | SDF | Download SDF |
| PubChem ID | 161387 | Appearance | Powder |
| Formula | C20H28O2 | M.Wt | 300.44 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC12CCCC(C1CCC34C2=CCC(C3)C(=C)C4)(C)C(=O)O | ||
| Standard InChIKey | RJIPNPHMQGDUBW-MZWQVCBVSA-N | ||
| Standard InChI | InChI=1S/C20H28O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h6,14-15H,1,4-5,7-12H2,2-3H3,(H,21,22)/t14?,15-,18+,19+,20?/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Siegesbeckia orientalis L.
| Description | 1. Pure Grandiflorenic acid can reproduce the uterine responses induced by zoapatle leaves aqueous extract , suggests that grandiflorenic acid may have antifertility effect. |
| Targets | Estrogen receptor | Progestogen receptor |
Grandiflorenic acid Dilution Calculator
Grandiflorenic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3285 mL | 16.6423 mL | 33.2845 mL | 66.569 mL | 83.2113 mL |
| 5 mM | 0.6657 mL | 3.3285 mL | 6.6569 mL | 13.3138 mL | 16.6423 mL |
| 10 mM | 0.3328 mL | 1.6642 mL | 3.3285 mL | 6.6569 mL | 8.3211 mL |
| 50 mM | 0.0666 mL | 0.3328 mL | 0.6657 mL | 1.3314 mL | 1.6642 mL |
| 100 mM | 0.0333 mL | 0.1664 mL | 0.3328 mL | 0.6657 mL | 0.8321 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The in vitro effect of grandiflorenic acid and zoapatle aqueous crude extract upon spontaneous contractility of the rat uterus during oestrus cycle.[Pubmed:6540830]
J Ethnopharmacol. 1984 Jun;11(1):87-97.
Montanoa tomentosa (zoapatle) is a Mexican plant popularly used for antifertility purposes and with promising characteristics for the development of a new oral contraceptive agent with uteroevacuant properties. In a previous pharmacological report we established the ambivalent myometrial response to zoapatle leaves aqueous extract (ZACE) depending on the animal species used and on the existence or absence of pregnancy. This fact could be useful in determining an appropriate medical use of zoapatle and suggests an interesting possible hormonal dependence in its mechanism of action. To elucidate the ZACE effect upon the pattern of uterine contractility in different hormonal stages, the rat uterus in vitro during oestrus cycle was studied. The aqueous crude extract of Montanoa tomentosa leaves produced different (or even opposite), effects on uterine motility during the distinct phases of the oestrus cycle in the rat. Furthermore, pure Grandiflorenic acid (GA), obtained from the phytochemical work up of this plant reproduced the uterine responses induced by ZACE. The action of zoapatle is discussed in relation to hormonal stage and to a probable adrenergic mechanism involved.
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