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Collagen proline hydroxylase inhibitor

Collagen proline hydroxylase inhibitor CAS# 223666-07-7

Collagen proline hydroxylase inhibitor

Catalog No. BCC1494----Order now to get a substantial discount!

Product Name & Size Price Stock
Collagen proline hydroxylase inhibitor: 5mg $403 In Stock
Collagen proline hydroxylase inhibitor: 10mg Please Inquire In Stock
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Chemical structure

Collagen proline hydroxylase inhibitor

3D structure

Chemical Properties of Collagen proline hydroxylase inhibitor

Cas No. 223666-07-7 SDF Download SDF
PubChem ID 9928521 Appearance Powder
Formula C18H18N4O4 M.Wt 354.36
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 13.15 mg/mL (37.11 mM; Need ultrasonic and warming)
Chemical Name N-ethyl-8-nitro-7-oxo-N-propyl-10H-1,10-phenanthroline-3-carboxamide
SMILES CCCN(CC)C(=O)C1=CN=C2C(=C1)C=CC3=C2NC=C(C3=O)[N+](=O)[O-]
Standard InChIKey XUARBCHSPWMKRC-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H18N4O4/c1-3-7-21(4-2)18(24)12-8-11-5-6-13-16(15(11)19-9-12)20-10-14(17(13)23)22(25)26/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,23)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Collagen proline hydroxylase inhibitor

DescriptionCollagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents.

Collagen proline hydroxylase inhibitor Dilution Calculator

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Collagen proline hydroxylase inhibitor Molarity Calculator

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Preparing Stock Solutions of Collagen proline hydroxylase inhibitor

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.822 mL 14.1099 mL 28.2199 mL 56.4398 mL 70.5497 mL
5 mM 0.5644 mL 2.822 mL 5.644 mL 11.288 mL 14.1099 mL
10 mM 0.2822 mL 1.411 mL 2.822 mL 5.644 mL 7.055 mL
50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.1288 mL 1.411 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5644 mL 0.7055 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Collagen proline hydroxylase inhibitor

IC50: N/A

Collagen proline hydroxylase inhibitor is one member of the collagen proline hydroxylase inhibitor family, which are used as antifibroproliferative agents. Proline hydroxylase is a multiple function oxygenase catalyzing specific prolyl residues in the collagen peptide precursor. Proline hydroxylase has been known as one of the critical enzymes in the biosynthesis of collagen and its activity is enhanced in tissues of various pathological fibrosis. Thus, the specific inhibitor of proline hydroxylase could have clinical application in fibrotic diseases treatment.

In vitro: One of collagen proline hydroxylase inhibitors, P-1894B, was found to in vitro inhibit proline hydroxylase and had been proposed as a topical treatment for dermal fibrosis. P-1894B was observed to be with similar activities on one fibroblast line from a patient with infection and two fibroblast lines from normal human skin. 72-hour drug exposure on growing cells showed both time- and dose-dependent inhibition of proliferation. A similar result was also observed in the epithelial cell line NCTC 2544 [1].

In vivo: So far, collagen proline hydroxylase inhibitor has not been applied to animal in vivo study.

Clinical trial: Currently, no clinical study is available.

Reference:
[1] Priestley GC.  Toxicity of the anthraquinone glycoside P-1894B for human skin fibroblasts. Br J Dermatol.1987 Jul;117(1):67-72.

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Description

Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents.

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