Humantenirine

CAS# 82375-30-2

Humantenirine

Catalog No. BCN4850----Order now to get a substantial discount!

Product Name & Size Price Stock
Humantenirine: 5mg $886 In Stock
Humantenirine: 10mg Please Inquire In Stock
Humantenirine: 20mg Please Inquire Please Inquire
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Quality Control of Humantenirine

Number of papers citing our products

Chemical structure

Humantenirine

3D structure

Chemical Properties of Humantenirine

Cas No. 82375-30-2 SDF Download SDF
PubChem ID 6441961 Appearance Powder
Formula C21H26N2O4 M.Wt 370.5
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC=C1CNC2CC3(C4CC1C2CO4)C5=C(C=C(C=C5)OC)N(C3=O)OC
Standard InChIKey ZORKKCARNQAZRJ-YHEJMRRESA-N
Standard InChI InChI=1S/C21H26N2O4/c1-4-12-10-22-17-9-21(19-8-14(12)15(17)11-27-19)16-6-5-13(25-2)7-18(16)23(26-3)20(21)24/h4-7,14-15,17,19,22H,8-11H2,1-3H3/b12-4+/t14-,15+,17+,19+,21+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Humantenirine

The herbs of Gelsemium sempervirens

Biological Activity of Humantenirine

TargetsP450 (e.g. CYP17)

Humantenirine Dilution Calculator

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Humantenirine Molarity Calculator

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Preparing Stock Solutions of Humantenirine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6991 mL 13.4953 mL 26.9906 mL 53.9811 mL 67.4764 mL
5 mM 0.5398 mL 2.6991 mL 5.3981 mL 10.7962 mL 13.4953 mL
10 mM 0.2699 mL 1.3495 mL 2.6991 mL 5.3981 mL 6.7476 mL
50 mM 0.054 mL 0.2699 mL 0.5398 mL 1.0796 mL 1.3495 mL
100 mM 0.027 mL 0.135 mL 0.2699 mL 0.5398 mL 0.6748 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Humantenirine

Cytotoxic steroids of Gelsemium sempervirens.[Pubmed:3655795]

J Nat Prod. 1987 Mar-Apr;50(2):195-8.

A new pregnane derivative, 12 beta-hydroxy-5 alpha-pregn-16-ene-3,20-dione, along with the known derivative 12 beta-hydroxy-pregna-4,16-diene-3,20-dione have been isolated from a MeOH extract of the stem of Gelsemium sempervirens and found to be the principal cytotoxic entities. The 13C-nmr spectra of both compounds were assigned by comparison with other pregnane analogs thereby allowing confirmation of the stereochemistry at C-5 in compound. Heteronuclear 2D correlation and selective INEPT experiments indicated the need to revise a number of 13C-nmr assignments of pregn-4,16-dien-3,20-dione. Nine indole alkaloids, gelsemine, gelsevirine, 21-oxogelsemine, gelsedine, 14 beta-hydroxygelsedine, gelsenicine, humantenidine, Humantenirine, and koumidine were found to be inactive in the KB and P-388 cytotoxicity test systems.

Inhibitory effects of cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots.[Pubmed:25764964]

J Ethnopharmacol. 2015 May 26;166:66-73.

ETHNOPHARMACOLOGICAL RELEVANCE: Gelsemium elegans (GE), widely distributed in East Asia, South East Asia and Northern America, is a kind of well-known toxic plant throughout the world. Yet it has been used as a Chinese folk medicine for treatment of malignant tumors, pain, rheumatic arthritis, psoriasis and immune function. AIM OF THE STUDY: The present study was to investigate the potential inhibitory effects of G. elegans (GE) roots on four major cytochrome P450 (CYP450) isoforms (CYP1A2, CYP2A6, CYP2E1 and CYP3A4) in vitro. MATERIALS AND METHODS: Four extracts (petroleum ether, dichloromethane, EtOAc and aqueous) of GE and two commercially available alkaloids (koumine and humantenmine) were screened for their CYP isoforms inhibitory activity. Four enzyme inhibition assays were examined according to the method of the literature. Phenacetin, coumarin, chlorzoxazone and testosterone were used as probe substrates in order to determine CYP1A2, CYP2A6, CYP2E1 and CYP3A4 catalytic activity, respectively. Each probe substrate was incubated with or without each extract and active constituent for corresponding isoform, followed by determination of the kinetics parameters, IC50 and Ki, to characterize inhibitory effects. RESULTS: GE dichloromethane extract selectively inhibited activities of CYP2E1 (IC50=29.04microg/ml) and CYP2A6 (IC50=46.84microg/ml), with Ki of 10.16 and 19.33microg/ml, respectively. In the case of alkaloids, koumine exhibited significant inhibitory effects on CYP2E1 while humantenmine showed more potent inhibition on CYP2E1 and CYP2A6 (IC50 of 47.44, 18.34 and 45.87microg/ml, Ki of 31.20, 35.06 and 52.06microg/ml, respectively). Because of their relatively high Ki values, the active constituents in GE dichloromethane extract were analyzed. The UPLC-DAD-ESI-MS/MS data showed that GE dichloromethane extract contains 6 kinds of indole alkaloids (koumine, humantenmine, humantenine, Humantenirine, N-methoxytaberpsychine, and sempervirine). As for CYP1A2 and CYP3A4, the negligible inhibitions were observed. CONCLUSION: G. elegans extracts inhibited several CYP450 enzyme activities with varying potency. Strong inhibition was observed in CYP2E1 and CYP2A6 isoforms by GE dichloromethane extract, koumine and humantenmine, inferring the involvement of alkaloids chemical constituents from GE dichloromethane extract in the effect.

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