Gomisin L2

CAS# 82425-44-3

Gomisin L2

Catalog No. BCN7032----Order now to get a substantial discount!

Product Name & Size Price Stock
Gomisin L2: 5mg $828 In Stock
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Quality Control of Gomisin L2

Number of papers citing our products

Chemical structure

Gomisin L2

3D structure

Chemical Properties of Gomisin L2

Cas No. 82425-44-3 SDF Download SDF
PubChem ID 5317807 Appearance Powder
Formula C22H26O6 M.Wt 386.44
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (9S,10R)-3,4,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-5-ol
SMILES CC1CC2=CC(=C(C(=C2C3=C(C4=C(C=C3CC1C)OCO4)OC)OC)OC)O
Standard InChIKey BVMLGLOHSDNEJG-NWDGAFQWSA-N
Standard InChI InChI=1S/C22H26O6/c1-11-6-13-8-15(23)19(24-3)21(25-4)17(13)18-14(7-12(11)2)9-16-20(22(18)26-5)28-10-27-16/h8-9,11-12,23H,6-7,10H2,1-5H3/t11-,12+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Gomisin L2

The fruits of Schizandra chinensis BAILL.

Biological Activity of Gomisin L2

DescriptionGomisin L2 is a natural product from Schizandra chinensis BAILL.

Protocol of Gomisin L2

Structure Identification
Chemical & Pharmaceutical Bulletin, 1982, 30(1):132-139.

The Constituents of Schizandra chinensis Baill. X. The Structures of .GAMMA.-schizandrin and four new lignans,(-)-gomisins L1 and L2,(.+-.)-gomisin M1 and (+)-gomisin M2.[Reference: WebLink]


METHODS AND RESULTS:
Four new dibenzocyclooctadiene lignans, named (-)-gomisin L1 (6) and (-)-Gomisin L2 (7), (±)-gomisin M1 (8) and (+)-gomisin M2 (9), were isolated from the fruits of Schizandra chinensis BAILL. (Schizandraceae). Their absolute structures were elucidated by means of chemical and spectral studies.
CONCLUSIONS:
The stereostructure of γ-schizandrin (1, dl-form), the plane structure of which had already been suggested by Kochetkov et al. and Liu et al., was also elucidated on the basis of chemical and spectral studies.

Gomisin L2 Dilution Calculator

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Gomisin L2 Molarity Calculator

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Preparing Stock Solutions of Gomisin L2

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5877 mL 12.9386 mL 25.8772 mL 51.7545 mL 64.6931 mL
5 mM 0.5175 mL 2.5877 mL 5.1754 mL 10.3509 mL 12.9386 mL
10 mM 0.2588 mL 1.2939 mL 2.5877 mL 5.1754 mL 6.4693 mL
50 mM 0.0518 mL 0.2588 mL 0.5175 mL 1.0351 mL 1.2939 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5175 mL 0.6469 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Gomisin L2

Kudsuphilactone B, a nortriterpenoid isolated from Schisandra chinensis fruit, induces caspase-dependent apoptosis in human ovarian cancer A2780 cells.[Pubmed:28229391]

Arch Pharm Res. 2017 Apr;40(4):500-508.

A phytochemical study on the fruits of Schisandra chinensis led to the isolation and characterization of nineteen compounds. The structures of the isolates were determined to be schizandrin, deoxyschizandrin, angeloylgomisin H, gomisin A, gomisin J, (-)-gomisin L1, (-)-Gomisin L2, wuweizisu C, gomisin N, meso-dihydroguaiaretic acid, kadsuphilactone B, alpha-ylangenol, alpha-ylangenyl acetate, beta-chamigrenal, beta-chamigrenic acid, 4-hydroxybenzoic acid, protocatechuic acid, p-methylcarvacrol, and indole-3-acetic acid. Of these, some lignans and a nortriterpene showed cytotoxic activity in human ovarian and endometrial cancer cells. In particular, a nortriterpenoid kadsuphilactone B exhibited significant cytotoxic activity with IC50 values below 25 muM in both A2780 and Ishikawa cells. Kadsuphilactone B induced apoptotic cell death and stimulated the activation of caspase-3, -8, and -9 and the cleavages of poly (ADP-ribose) polymerase. Caspase inhibitors attenuated the pro-apoptotic activity of kudsuphilactone B. In addition, kadsuphilactone B altered the expression levels of B cell lymphoma 2 (Bcl-2) family proteins. Moreover, activation of MAPKs was modulated by kadsuphilactone B in a dose-dependent manner. Taken together, these results show that kadsuphilactone B induces caspase-dependent apoptosis in human cancer cells via the regulation of Bcl-2 family protein and MAPK signaling.

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