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20-O-Acetylingenol-3-angelate

CAS# 82425-35-2

20-O-Acetylingenol-3-angelate

Catalog No. BCN8469----Order now to get a substantial discount!

Product Name & Size Price Stock
20-O-Acetylingenol-3-angelate: 5mg Please Inquire In Stock
20-O-Acetylingenol-3-angelate: 10mg Please Inquire In Stock
20-O-Acetylingenol-3-angelate: 20mg Please Inquire Please Inquire
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Quality Control of 20-O-Acetylingenol-3-angelate

Number of papers citing our products

Chemical structure

20-O-Acetylingenol-3-angelate

3D structure

Chemical Properties of 20-O-Acetylingenol-3-angelate

Cas No. 82425-35-2 SDF Download SDF
PubChem ID 9934504 Appearance Orange red powder
Formula C27H36O7 M.Wt 472.57
Type of Compound Diterpenoids Storage Desiccate at -20°C
Synonyms Euphorbia factor Pe1
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,4S,5S,6R,9S,10R,12R,14R)-7-(acetyloxymethyl)-5,6-dihydroxy-3,11,11,14-tetramethyl-15-oxo-4-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dienyl] (Z)-2-methylbut-2-enoate
SMILES CC=C(C)C(=O)OC1C(=CC23C1(C(C(=CC(C2=O)C4C(C4(C)C)CC3C)COC(=O)C)O)O)C
Standard InChIKey ZYCAGKYWXRKLSN-KLKWOBOISA-N
Standard InChI InChI=1S/C27H36O7/c1-8-13(2)24(31)34-23-14(3)11-26-15(4)9-19-20(25(19,6)7)18(22(26)30)10-17(12-33-16(5)28)21(29)27(23,26)32/h8,10-11,15,18-21,23,29,32H,9,12H2,1-7H3/b13-8-/t15-,18+,19-,20+,21-,23+,26+,27+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 20-O-Acetylingenol-3-angelate

The seeds of Euphorbia lathyris L.

Protocol of 20-O-Acetylingenol-3-angelate

Structure Identification
US 20140350120 A1[P]. 2014.

Topical composition comprising an ingenol derivative and a surfactant-cosolvent mixture.[Reference: WebLink]


METHODS AND RESULTS:
The term “ingenol derivative” is intended to mean an ingenol compound isolated from a species of Euphorbia, in particular from E. peplus, or an ingenol derivative prepared by chemical synthesis or by a semi-synthetic route, e.g. as disclosed in copending application No. PCT/DK2011/000081. Examples of ingenol derivatives that may be included in the present compositions are ingenol-3-angelate, ingenol-5-angelate, ingenol-20-angelate, 20-O-Acetylingenol-3-angelate and 20-deoxy-ingenol-3-angelate.
CONCLUSIONS:
Ingenol-3-angelate, also known as ingenol-3-mebutate or PEP 005, is currently in development for the treatment of actinic keratosis.

20-O-Acetylingenol-3-angelate Dilution Calculator

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20-O-Acetylingenol-3-angelate Molarity Calculator

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Preparing Stock Solutions of 20-O-Acetylingenol-3-angelate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1161 mL 10.5804 mL 21.1609 mL 42.3218 mL 52.9022 mL
5 mM 0.4232 mL 2.1161 mL 4.2322 mL 8.4644 mL 10.5804 mL
10 mM 0.2116 mL 1.058 mL 2.1161 mL 4.2322 mL 5.2902 mL
50 mM 0.0423 mL 0.2116 mL 0.4232 mL 0.8464 mL 1.058 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4232 mL 0.529 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on 20-O-Acetylingenol-3-angelate

20-O-Acetylingenol-3-angelate is a natural compound.

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Description

20-O-Acetylingenol-3-angelate is a natural compound.

Keywords:

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