Isorhamnetin-3-O-beta-D-GlucosideCAS# 5041-82-7 |
- Isorhamnetin-3-O-galactoside
Catalog No.:BCC8190
CAS No.:6743-92-6
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 5041-82-7 | SDF | Download SDF |
| PubChem ID | 5318645 | Appearance | Yellow powder |
| Formula | C22H22O12 | M.Wt | 478.40 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 250 mg/mL (522.58 mM; Need ultrasonic) | ||
| Chemical Name | 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | ||
| SMILES | COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O | ||
| Standard InChIKey | CQLRUIIRRZYHHS-LFXZADKFSA-N | ||
| Standard InChI | InChI=1S/C22H22O12/c1-31-12-4-8(2-3-10(12)25)20-21(17(28)15-11(26)5-9(24)6-13(15)32-20)34-22-19(30)18(29)16(27)14(7-23)33-22/h2-6,14,16,18-19,22-27,29-30H,7H2,1H3/t14-,16-,18+,19-,22+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Isorhamnetine-3-O-rutinoside inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
| Targets | IL Receptor |
| In vitro | Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.[Pubmed: 15863906]Biol Pharm Bull. 2005 May;28(5):916-8.The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. A review of chemistry and biological activities of the genus Aerva--a desert plant.[Pubmed: 22568031]Acta Pol Pharm. 2012 Mar-Apr;69(2):171-7.There are approximately 28 species of Aerva genus, but only a few species are medicinal of which A. persica, A. lanata and A. javanica are of great value. Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity.[Pubmed: 18409066 ]J Nat Med. 2008 Jul;62(3):349-53.The dayflower, Commelina communis L., contains 1-deoxynojirimycin (DNJ) and (2R,3R,4R,5R)2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidine (DMDP), potent alpha-glucosidase inhibitors. The extracts and powder of this herb are important food materials for prophylaxis against type 2 diabetes. |
| Cell Research | Isolation of new cytotoxic metabolites from Cleome droserifolia growing in Egypt.[Pubmed: 22888531]Z Naturforsch C. 2012 May-Jun;67(5-6):266-74.The sulforhodamine B (SRB) assay was used to assess the cytotoxicity of the aqueous (AqEx) and ethanolic (AlEx) extracts, respectively, of the aerial parts of Cleome droserifolia (Forssk.) Del. against two human cancer cell lines, breast (MCF7) and colon (HCT116) adenocarcinoma. |
| Structure Identification | Molecules. 2012 Apr 17;17(4):4595-603.A new isorhamnetin glycoside and other phenolic compounds from Callianthemum taipaicum.[Pubmed: 22510608]A new flavonol glycoside together with five known phenolic compounds were isolated from the whole herb of Callianthemum taipaicum. |
Isorhamnetin-3-O-beta-D-Glucoside Dilution Calculator
Isorhamnetin-3-O-beta-D-Glucoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0903 mL | 10.4515 mL | 20.903 mL | 41.806 mL | 52.2575 mL |
| 5 mM | 0.4181 mL | 2.0903 mL | 4.1806 mL | 8.3612 mL | 10.4515 mL |
| 10 mM | 0.209 mL | 1.0452 mL | 2.0903 mL | 4.1806 mL | 5.2258 mL |
| 50 mM | 0.0418 mL | 0.209 mL | 0.4181 mL | 0.8361 mL | 1.0452 mL |
| 100 mM | 0.0209 mL | 0.1045 mL | 0.209 mL | 0.4181 mL | 0.5226 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Isoliquiritin
Catalog No.:BCN5945
CAS No.:5041-81-6
- Juglanin
Catalog No.:BCN6505
CAS No.:5041-67-8
- 3-Nitropropionic acid
Catalog No.:BCC6303
CAS No.:504-88-1
- DL-Homocysteic acid
Catalog No.:BCN2233
CAS No.:504-33-6
- 4-Aminopyridine
Catalog No.:BCC5267
CAS No.:504-24-5
- Orcinol
Catalog No.:BCN5612
CAS No.:504-15-4
- (-)-di-de-Omethylgrandisin
Catalog No.:BCN7872
CAS No.:50393-98-1
- Cyclo(Phe-Gly)
Catalog No.:BCN2431
CAS No.:5037-75-2
- Apixaban
Catalog No.:BCC2295
CAS No.:503612-47-3
- Pentamidine dihydrochloride
Catalog No.:BCC5194
CAS No.:50357-45-4
- glucagon receptor antagonists 1
Catalog No.:BCC1593
CAS No.:503559-84-0
- NU7441 (KU-57788)
Catalog No.:BCC3679
CAS No.:503468-95-9
- 1,5,6-Trihydroxyxanthone
Catalog No.:BCN7642
CAS No.:5042-03-5
- Methyl 2alpha-hydroxyhardwickiate
Catalog No.:BCN7595
CAS No.:50428-93-8
- GW441756
Catalog No.:BCC5093
CAS No.:504433-23-2
- Araneosol
Catalog No.:BCN5613
CAS No.:50461-86-4
- Homopiperazine
Catalog No.:BCC8995
CAS No.:505-66-8
- 3-(Carboxymethylamino)propanoic acid
Catalog No.:BCN1791
CAS No.:505-72-6
- Fenspiride HCl
Catalog No.:BCC4659
CAS No.:5053-08-7
- Columbianadin
Catalog No.:BCN1275
CAS No.:5058-13-9
- Isojacareubin
Catalog No.:BCN6883
CAS No.:50597-93-8
- Arachidonic acid
Catalog No.:BCN2215
CAS No.:506-32-1
- Nervonic acid
Catalog No.:BCN8374
CAS No.:506-37-6
- Octacosanoic Acid
Catalog No.:BCN5395
CAS No.:506-48-9
A review of chemistry and biological activities of the genus Aerva--a desert plant.[Pubmed:22568031]
Acta Pol Pharm. 2012 Mar-Apr;69(2):171-7.
There are approximately 28 species of Aerva genus, but only a few species are medicinal of which A. persica, A. lanata and A. javanica are of great value. A number of flavonol glycosides (e.g., aervanone, kaempferol-3-galactoside, Isorhamnetin-3-O-beta-D-Glucoside) have been reported from Aerva persica as major phytoconstituents and the minor constituents are beta-cyanins (glycine betaine and trigonelline), sterols and carbohydrates. This plant is used as medicinal herb in several traditional systems of medicine all over the world, like diuretic, demulcent, purgative, emetic and tinder. Aerva plants are used to cure ulcer, lithiasis, dropsical affections, eye affection, toothache, headache, in disorders of abdomen and inflammation of internal organs. Roots and flowers are reported to possess hypoglycemic, antioxidant, anthelmintic, analgesic, antimalarial, antivenin activities and medicinal properties against rheumatism and kidney troubles.
Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity.[Pubmed:18409066]
J Nat Med. 2008 Jul;62(3):349-53.
The dayflower, Commelina communis L., contains 1-deoxynojirimycin (DNJ) and (2R,3R,4R,5R)2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidine (DMDP), potent alpha-glucosidase inhibitors. The extracts and powder of this herb are important food materials for prophylaxis against type 2 diabetes. Eleven flavonoid glycosides as antioxidants, isoquercitrin, isorhamnetin-3-O-rutinoside, Isorhamnetin-3-O-beta-D-Glucoside, glucoluteolin, chrysoriol-7-O-beta-D-glucoside, orientin, vitexin, isoorientin, isovitexin, swertisin, and flavocommelin, were identified from the aerial parts of C. communis. Their antioxidant activities were measured using in vitro assays employing the 1,1-diphenyl-2-picrylhydrazyl radical- and superoxide radical-scavenging assays. The results showed that glucoluteolin, orientin, isoorientin, and isoquercitrin are the predominant antioxidants in this herb. Moreover, isoquercitrin, isorhamnetine-3-O-rutinoside, vitexin, and swertisin inhibited the activity of alpha-glucosidase from rat intestine.
Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.[Pubmed:15863906]
Biol Pharm Bull. 2005 May;28(5):916-8.
The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. The various fractions from the MeOH extract of S. herbacea were tested for their effects on RLAR in vitro. Among them, the EtOAc fraction was found to exhibit a potent RLAR inhibition (IC(50)=0.75 microg/ml), from which an active principle as a potent AR inhibitor was isolated and its chemical structure was elucidated as Isorhamnetin-3-O-beta-D-Glucoside (1) by spectral analysis. Compound 1 exhibited a potent RLAR inhibition in vitro, its IC(50) being 1.4 microM. Compound 1, when administered orally at 25 mg/kg in streptozotocin (STZ)-induced diabetic rats, caused not only a significant inhibition of serum glucose concentration but also sorbitol accumulation in the lenses, red blood cells (RBC), and sciatic nerves. These results indicate that compound 1 from S. herbacea is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.
Isolation of new cytotoxic metabolites from Cleome droserifolia growing in Egypt.[Pubmed:22888531]
Z Naturforsch C. 2012 May-Jun;67(5-6):266-74.
The sulforhodamine B (SRB) assay was used to assess the cytotoxicity of the aqueous (AqEx) and ethanolic (AlEx) extracts, respectively, of the aerial parts of Cleome droserifolia (Forssk.) Del. against two human cancer cell lines, breast (MCF7) and colon (HCT116) adenocarcinoma. AqEx exhibited higher cytotoxic activity, thus its four subfractions, namely n-hexane (HxFr), chloroform (ClFr), ethyl acetate (EtFr), and n-butanol (BuFr) fractions, were also tested. Purification of the more active ClFr and EtFr yielded nine compounds. Six terpenoids, guai-7(11),8-diene (C1), 1-hydroxy-guai-3,10(14)-diene (C2), 18-hydroxydollabela-8(17)-ene (C3), (24E)-stigmasta-5,8-dien-3beta-ol (C4), teucladiol [1alpha,5beta-guai-10(14)-ene-4beta,6beta-diol] (C5), and buchariol (4,10-epoxy-6a-hydroxyguaiane) (C6), were isolated from ClFr and three flavonol glycosides, Isorhamnetin-3-O-beta-D-Glucoside (F1), quercetin-3'-methoxy-3-O-(4"-acetylrhamnoside)-7-O-alpha-rhamnoside (F2), and kaempferol-4'-methoxy-3,7-O-dirhamnoside (F3), were isolated from EtFr. Compounds C3 and F2 are new in nature. The isolated compounds were identified using various spectroscopic methods (UV, IR, 1H NMR, 13C NMR, HMQC, HMBC, and COSY). Compounds C1, C3, F2, and F3 showed significant cytotoxic activities against the two tested cell lines comparable to those of the anticancer drug doxorubicin. The new compound C3 was the most active as it had the lowest IC50 values, (1.9 +/- 0.08) and (1.6 +/- 0.09) microg/ml corresponding to 6.5 and 5.4 microM, against MCF7 and HCT116 cells, respectively.
A new isorhamnetin glycoside and other phenolic compounds from Callianthemum taipaicum.[Pubmed:22510608]
Molecules. 2012 Apr 17;17(4):4595-603.
A new flavonol glycoside together with five known phenolic compounds were isolated from the whole herb of Callianthemum taipaicum. The compounds were identified as isorhamnetin-3-O-alpha-L-arabinoside-7-O-beta-D-glucoside (1), Isorhamnetin-3-O-beta-D-Glucoside (2), dibutyl phthalate (3), (+)-1-hydroxylpinoresinol-4'-beta-D-glucoside (4), pinoresinol-4'-O-beta-D-glucoside (5) and 2-phenylethyl-beta-primeveroside (6). Compound 1 was identified as a new flavonol glycoside. The compound 6 was isolated for the first time as natural product. All compounds were isolated for the first time from the Callianthemum genus. Furthermore, the 2D-NMR data of the four known compounds 2-5 are given for the first time in this paper. All the structures were identified on the basis of detailed spectral analysis. The compounds 1 and 4 exhibited certain antifungal activity.
