JW 480

Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1) CAS# 1354359-53-7

JW 480

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Catalog No. BCC6142----Order now to get a substantial discount!

Product Name & Size Price Stock
JW 480: 5mg $69 In Stock
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JW 480

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Chemical Properties of JW 480

Cas No. 1354359-53-7 SDF Download SDF
PubChem ID 57330099 Appearance Powder
Formula C22H23NO2 M.Wt 333.42
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
Chemical Name (2-propan-2-ylphenyl) N-(2-naphthalen-2-ylethyl)carbamate
SMILES CC(C)C1=CC=CC=C1OC(=O)NCCC2=CC3=CC=CC=C3C=C2
Standard InChIKey PCNJGBMWAZRVEA-UHFFFAOYSA-N
Standard InChI InChI=1S/C22H23NO2/c1-16(2)20-9-5-6-10-21(20)25-22(24)23-14-13-17-11-12-18-7-3-4-8-19(18)15-17/h3-12,15-16H,13-14H2,1-2H3,(H,23,24)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of JW 480

DescriptionPotent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50 = 20 nM in mouse brain). Impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo. Reduces monoalkylglycerol ether (MAGE) levels.

JW 480 Dilution Calculator

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JW 480 Molarity Calculator

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Preparing Stock Solutions of JW 480

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9992 mL 14.9961 mL 29.9922 mL 59.9844 mL 74.9805 mL
5 mM 0.5998 mL 2.9992 mL 5.9984 mL 11.9969 mL 14.9961 mL
10 mM 0.2999 mL 1.4996 mL 2.9992 mL 5.9984 mL 7.4981 mL
50 mM 0.06 mL 0.2999 mL 0.5998 mL 1.1997 mL 1.4996 mL
100 mM 0.03 mL 0.15 mL 0.2999 mL 0.5998 mL 0.7498 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on JW 480

A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis.[Pubmed:21513884]

Chem Biol. 2011 Apr 22;18(4):476-84.

Cancer cells show alterations in metabolism that support malignancy and disease progression. Prominent among these metabolic changes is elevations in neutral ether lipids (NELs). We have previously shown that the hydrolytic enzyme KIAA1363 (or AADACL1) is highly elevated in aggressive cancer cells, where it plays a key role in generating the monoalkylglycerol ether (MAGE) class of NELs. Here, we use activity-based protein profiling-guided medicinal chemistry to discover a highly potent and selective inhibitor of KIAA1363, the carbamate JW480. We show that JW480, and an shRNA probe that targets KIAA1363, reduce MAGEs and impair the migration, invasion, survival, and in vivo tumor growth of human prostate cancer cell lines. These findings indicate that the KIAA1363-MAGE pathway is important for prostate cancer pathogenesis and designate JW480 as a versatile pharmacological probe for disrupting this pro-tumorigenic metabolic pathway.

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