Kamebanin

CAS# 39388-57-3

Kamebanin

Catalog No. BCN5449----Order now to get a substantial discount!

Product Name & Size Price Stock
Kamebanin: 5mg $903 In Stock
Kamebanin: 10mg Please Inquire In Stock
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Kamebanin: 500mg Please Inquire Please Inquire
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Quality Control of Kamebanin

Number of papers citing our products

Chemical structure

Kamebanin

3D structure

Chemical Properties of Kamebanin

Cas No. 39388-57-3 SDF Download SDF
PubChem ID 12004580 Appearance Powder
Formula C20H30O4 M.Wt 334.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,2R,4R,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one
SMILES CC1(CCC(C2(C1CC(C34C2CCC(C3O)C(=C)C4=O)O)C)O)C
Standard InChIKey VSDVMWBRICFVRW-BIGDWJEQSA-N
Standard InChI InChI=1S/C20H30O4/c1-10-11-5-6-12-19(4)13(18(2,3)8-7-14(19)21)9-15(22)20(12,16(10)23)17(11)24/h11-15,17,21-22,24H,1,5-9H2,2-4H3/t11-,12-,13+,14-,15+,17+,19-,20-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Kamebanin

The herbs of Rabdosia excisa (Maxim.)Hara

Biological Activity of Kamebanin

Description1. Kamebanin, a natural diterpenoid, has antibacterial activity. 2. Kamebanin shows efficient cytotoxic activity against HeLa and HL-60 cells.
TargetsAntifection

Kamebanin Dilution Calculator

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Kamebanin Molarity Calculator

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Preparing Stock Solutions of Kamebanin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9895 mL 14.9477 mL 29.8954 mL 59.7907 mL 74.7384 mL
5 mM 0.5979 mL 2.9895 mL 5.9791 mL 11.9581 mL 14.9477 mL
10 mM 0.299 mL 1.4948 mL 2.9895 mL 5.9791 mL 7.4738 mL
50 mM 0.0598 mL 0.299 mL 0.5979 mL 1.1958 mL 1.4948 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5979 mL 0.7474 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Kamebanin

The cytotoxic activity of diterpenoids from Isodon species.[Pubmed:22978208]

Nat Prod Commun. 2012 Aug;7(8):977-8.

Fifteen Isodon diterpenoids (1-15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells. Kamebanin (14) showed efficient cytotoxic activity against HeLa and HL-60 cells. In addition, although dihydroenmein (2) and trichorabdal B (7) were inactive against several tested cell types, they were found to have cytotoxic-enhancing activity of VCR against VCR-resistant P388 cells.

The natural diterpenoid kamebanin.[Pubmed:12050429]

Acta Crystallogr C. 2002 Jun;58(Pt 6):o323-4. Epub 2002 May 11.

Kamebanin, alternatively called rel-(-)-(1R,4R,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5,5,9-trimethyl-14-methylenet etracyclo[11.2.1.0(1,10).0(4,9)]hexadecan-15-one, C(20)H(30)O(4), is a natural diterpenoid which has cytotoxic and antibacterial activity. The molecule is composed of three six-membered rings, which all adopt chair conformations, and one five-membered ring, which adopts an envelope conformation. The conjugated alpha-methylenecyclopentanone ring is the active part in the molecule due to the ring strain. All three hydroxy groups serve as hydrogen-bond donors and acceptors, forming a continuous two-dimensional network.

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