Lipiferolide

CAS# 41059-80-7

Lipiferolide

Catalog No. BCN5463----Order now to get a substantial discount!

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Quality Control of Lipiferolide

Number of papers citing our products

Chemical structure

Lipiferolide

3D structure

Chemical Properties of Lipiferolide

Cas No. 41059-80-7 SDF Download SDF
PubChem ID 5281478 Appearance Powder
Formula C17H22O5 M.Wt 306.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=CCCC2(C(O2)C3C(C(C1)OC(=O)C)C(=C)C(=O)O3)C
Standard InChIKey ODYJJNFWFYUXSS-CTSUEIOESA-N
Standard InChI InChI=1S/C17H22O5/c1-9-6-5-7-17(4)15(22-17)14-13(10(2)16(19)21-14)12(8-9)20-11(3)18/h6,12-15H,2,5,7-8H2,1,3-4H3/b9-6+/t12-,13-,14+,15?,17-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lipiferolide

The herbs of Liriodendron tulipifera

Biological Activity of Lipiferolide

Description1. Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells. 2. Liriodenine has antiplasmodial activity. 3. Lipiferolide and epitulipinolide diepoxide possess cytotoxic activity against KB cells.
TargetsAntifection

Lipiferolide Dilution Calculator

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Lipiferolide Molarity Calculator

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Preparing Stock Solutions of Lipiferolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2637 mL 16.3185 mL 32.6371 mL 65.2742 mL 81.5927 mL
5 mM 0.6527 mL 3.2637 mL 6.5274 mL 13.0548 mL 16.3185 mL
10 mM 0.3264 mL 1.6319 mL 3.2637 mL 6.5274 mL 8.1593 mL
50 mM 0.0653 mL 0.3264 mL 0.6527 mL 1.3055 mL 1.6319 mL
100 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.6527 mL 0.8159 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lipiferolide

Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.[Pubmed:20826204]

J Ethnopharmacol. 2011 Jan 7;133(1):26-30.

AIM OF THE STUDY: The objective of this study was to isolate and characterize the active constituents of the traditionally used antimalarial plant Liriodendron tulipifera by antiplasmodial-assay guided fractionation. MATERIALS AND METHODS: Bark and leaves were extracted with solvents of increasing polarity. Fractions were generated using flash chromatography, counter current chromatography and preparative HPLC and subjected to in vitro antiplasmodial and cytotoxicity assays. Active fractions were subjected to further fractionation until pure compounds were isolated, for which the IC(50) values were calculated. RESULTS AND DISCUSSION: Six known aporphine alkaloids, asimilobine (1), norushinsunine (2), norglaucine (3), liriodenine (4), anonaine (5) and oxoglaucine (6) were found to be responsible for the antiplasmodial activity of the bark. Leaves yielded two known sesquiterpene lactones, peroxyferolide (7) and Lipiferolide (8) with antiplasmodial activity. The antiplasmodial activity of (2) (IC(50)=29.6 mug/mL), (3) (IC(50)=22.0 mug/mL), (6) (IC(50)=9.1 mug/mL), (7) (IC(50)=6.2 mug/mL) and (8) (IC(50)=1.8 mug/mL) are reported for the first time. CONCLUSION: This work supports the historical use of Liriodendron tulipifera as an antimalarial remedy of the United States and characterizes its antiplasmodial constituents.

Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera.[Pubmed:17424934]

Arch Pharm Res. 2007 Mar;30(3):299-302.

The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of Lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.

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