LirinidineCAS# 54383-28-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 54383-28-7 | SDF | Download SDF |
| PubChem ID | 31069 | Appearance | Powder |
| Formula | C18H19NO2 | M.Wt | 281.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (6aS)-2-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1-ol | ||
| SMILES | CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)O)OC | ||
| Standard InChIKey | YXVXMURDCBMPRH-AWEZNQCLSA-N | ||
| Standard InChI | InChI=1S/C18H19NO2/c1-19-8-7-12-10-15(21-2)18(20)17-13-6-4-3-5-11(13)9-14(19)16(12)17/h3-6,10,14,20H,7-9H2,1-2H3/t14-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. (+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells. 2. (-)-Lirinidine shows potent inhibition of melanogenesis. 3. Lirinidine exhibits significant inhibition of collagen, arachidonic acid and platelet activating factor-induced platelet aggregation. |
| Targets | PAFR |
Lirinidine Dilution Calculator
Lirinidine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5537 mL | 17.7683 mL | 35.5366 mL | 71.0732 mL | 88.8415 mL |
| 5 mM | 0.7107 mL | 3.5537 mL | 7.1073 mL | 14.2146 mL | 17.7683 mL |
| 10 mM | 0.3554 mL | 1.7768 mL | 3.5537 mL | 7.1073 mL | 8.8842 mL |
| 50 mM | 0.0711 mL | 0.3554 mL | 0.7107 mL | 1.4215 mL | 1.7768 mL |
| 100 mM | 0.0355 mL | 0.1777 mL | 0.3554 mL | 0.7107 mL | 0.8884 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antioxidant and anticancer constituents from the leaves of Liriodendron tulipifera.[Pubmed:24705566]
Molecules. 2014 Apr 3;19(4):4234-45.
Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (-)-anonaine (1), (-)-liridinine (3), (+)-Lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.
Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea.[Pubmed:9883592]
Phytochemistry. 1998 Dec;49(7):2015-8.
Bioactivity-directed fractionation led to the isolation of two new 7-dehydroaporphine alkaloids, 7-hydroxy-dehydrothalicsimidine (1) and 7-formyl-dehydrothalicsimidine (2), along with the five known alkaloids, thalicsimidine (3), norpurpureine (4), N-methyllaurotetanine (5), Lirinidine (6) and N-methylasimilobine (7), from the leaves of Annona purpurea. Structural elucidation of these compounds was established by mass and spectroscopic analyses. Among them, 1, 3, 4, 6 and 7 exhibited significant inhibition of collagen, arachidonic acid and platelet activating factor-induced platelet aggregation; 1 also showed inhibition against thrombin-induced platelet aggregation.
