Lirinidine

CAS# 54383-28-7

Lirinidine

Catalog No. BCN8274----Order now to get a substantial discount!

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Lirinidine: 5mg $161 In Stock
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Quality Control of Lirinidine

Number of papers citing our products

Chemical structure

Lirinidine

3D structure

Chemical Properties of Lirinidine

Cas No. 54383-28-7 SDF Download SDF
PubChem ID 31069 Appearance Powder
Formula C18H19NO2 M.Wt 281.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (6aS)-2-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1-ol
SMILES CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)O)OC
Standard InChIKey YXVXMURDCBMPRH-AWEZNQCLSA-N
Standard InChI InChI=1S/C18H19NO2/c1-19-8-7-12-10-15(21-2)18(20)17-13-6-4-3-5-11(13)9-14(19)16(12)17/h3-6,10,14,20H,7-9H2,1-2H3/t14-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lirinidine

The leaves of Nelumbo nucifera

Biological Activity of Lirinidine

Description1. (+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells. 2. (-)-Lirinidine shows potent inhibition of melanogenesis. 3. Lirinidine exhibits significant inhibition of collagen, arachidonic acid and platelet activating factor-induced platelet aggregation.
TargetsPAFR

Lirinidine Dilution Calculator

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Lirinidine Molarity Calculator

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Preparing Stock Solutions of Lirinidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5537 mL 17.7683 mL 35.5366 mL 71.0732 mL 88.8415 mL
5 mM 0.7107 mL 3.5537 mL 7.1073 mL 14.2146 mL 17.7683 mL
10 mM 0.3554 mL 1.7768 mL 3.5537 mL 7.1073 mL 8.8842 mL
50 mM 0.0711 mL 0.3554 mL 0.7107 mL 1.4215 mL 1.7768 mL
100 mM 0.0355 mL 0.1777 mL 0.3554 mL 0.7107 mL 0.8884 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lirinidine

Antioxidant and anticancer constituents from the leaves of Liriodendron tulipifera.[Pubmed:24705566]

Molecules. 2014 Apr 3;19(4):4234-45.

Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (-)-anonaine (1), (-)-liridinine (3), (+)-Lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.

Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea.[Pubmed:9883592]

Phytochemistry. 1998 Dec;49(7):2015-8.

Bioactivity-directed fractionation led to the isolation of two new 7-dehydroaporphine alkaloids, 7-hydroxy-dehydrothalicsimidine (1) and 7-formyl-dehydrothalicsimidine (2), along with the five known alkaloids, thalicsimidine (3), norpurpureine (4), N-methyllaurotetanine (5), Lirinidine (6) and N-methylasimilobine (7), from the leaves of Annona purpurea. Structural elucidation of these compounds was established by mass and spectroscopic analyses. Among them, 1, 3, 4, 6 and 7 exhibited significant inhibition of collagen, arachidonic acid and platelet activating factor-induced platelet aggregation; 1 also showed inhibition against thrombin-induced platelet aggregation.

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