3alpha-dihydrocadambineCAS# 54483-84-0 |
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| Cas No. | 54483-84-0 | SDF | Download SDF |
| PubChem ID | 162138 | Appearance | Powder |
| Formula | C27H34N2O10 | M.Wt | 546.6 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | COC(=O)C1=COC(C2C1CC3C4=C(CCN3CC2O)C5=CC=CC=C5N4)OC6C(C(C(C(O6)CO)O)O)O | ||
| Standard InChIKey | HNZGKRAKJFZQAY-SBAWYOAKSA-N | ||
| Standard InChI | InChI=1S/C27H34N2O10/c1-36-25(35)15-11-37-26(39-27-24(34)23(33)22(32)19(10-30)38-27)20-14(15)8-17-21-13(6-7-29(17)9-18(20)31)12-4-2-3-5-16(12)28-21/h2-5,11,14,17-20,22-24,26-28,30-34H,6-10H2,1H3/t14-,17+,18-,19-,20+,22-,23+,24-,26+,27+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The heartwood of Anthocephalus cadamba
| Description | 1. 3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. |
3alpha-dihydrocadambine Dilution Calculator
3alpha-dihydrocadambine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8295 mL | 9.1475 mL | 18.2949 mL | 36.5898 mL | 45.7373 mL |
| 5 mM | 0.3659 mL | 1.8295 mL | 3.659 mL | 7.318 mL | 9.1475 mL |
| 10 mM | 0.1829 mL | 0.9147 mL | 1.8295 mL | 3.659 mL | 4.5737 mL |
| 50 mM | 0.0366 mL | 0.1829 mL | 0.3659 mL | 0.7318 mL | 0.9147 mL |
| 100 mM | 0.0183 mL | 0.0915 mL | 0.1829 mL | 0.3659 mL | 0.4574 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Gluco-indole alkaloids from Nauclea cadamba in Thailand and transformation of 3 alpha-dihydrocadambine into the indolopyridine alkaloid, 16-carbomethoxynaufoline.[Pubmed:12576667]
Chem Pharm Bull (Tokyo). 2003 Feb;51(2):232-3.
Three monoterpenoid gluco-indole alkaloids, 3beta-isodihydrocadambine, cadambine, and 3alpha-dihydrocadambine, were isolated from Nauclea cadamba ROXB. growing in Thailand. The stereochemistry at C19 in 3beta-isodihydrocadambine was elucidated to be R by spectroscopic analysis. Treatment of 3alpha-dihydrocadambine with beta-glucosidase in aqueous ammonium acetate solution gave an indolopyridine alkaloid, 16-carbomethoxynaufoline, and an unusually rearranged compound.
Hypotensive action of 3alpha-dihydrocadambine, an indole alkaloid glycoside of uncaria hooks1.[Pubmed:17342601]
Planta Med. 1985 Oct;51(5):424-7.
3alpha-dihydrocadambine exhibited dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. Its activity was much stronger and longer-lasting than that of rhynchophylline. In anesthetized dogs, it caused dilation of the vertebral, femoral and common carotid arteries, and had almost no effect on the coronary artery, whereas it had almost no significant activity in isolated canine arterial strip preparations.
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