LydicamycinCAS# 133352-27-9 |
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| Cas No. | 133352-27-9 | SDF | Download SDF |
| PubChem ID | 90469739 | Appearance | Powder |
| Formula | C47H74N4O10 | M.Wt | 855.12 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2-[(4E,8E,12E,16E)-21-[1-[(E)-(2,4-dioxopyrrolidin-3-ylidene)-hydroxymethyl]-5,6-dihydroxy-1,3-dimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-2-yl]-2,6,10,14,18-pentahydroxy-5,11,17,19-tetramethylhenicosa-4,8,12,16-tetraenyl]pyrrolidine-1-carboximidamide | ||
| SMILES | CC1=CC2C(CCC(C2O)O)C(C1CCC(C)C(C(=CCC(C=CC(C)C(C=CCC(C(=CCC(CC3CCCN3C(=N)N)O)C)O)O)O)C)O)(C)C(=C4C(=O)CNC4=O)O | ||
| Standard InChIKey | HNSRCWWMQWCNGW-YCUXMAJDSA-N | ||
| Standard InChI | InChI=1S/C47H74N4O10/c1-26(37(54)10-7-11-38(55)27(2)13-18-33(53)24-31-9-8-22-51(31)46(48)49)12-16-32(52)17-14-28(3)42(58)29(4)15-19-35-30(5)23-34-36(20-21-39(56)43(34)59)47(35,6)44(60)41-40(57)25-50-45(41)61/h7,10,12-14,16,23,26,29,31-39,42-43,52-56,58-60H,8-9,11,15,17-22,24-25H2,1-6H3,(H3,48,49)(H,50,61)/b10-7+,16-12+,27-13+,28-14+,44-41+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The Streptomyces aureofaciens
| Description | 1. Lydicamycin is active against Gram-positive bacteria and a certain yeast. |
| Targets | Antifection |
Lydicamycin Dilution Calculator
Lydicamycin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.1694 mL | 5.8471 mL | 11.6943 mL | 23.3885 mL | 29.2357 mL |
| 5 mM | 0.2339 mL | 1.1694 mL | 2.3389 mL | 4.6777 mL | 5.8471 mL |
| 10 mM | 0.1169 mL | 0.5847 mL | 1.1694 mL | 2.3389 mL | 2.9236 mL |
| 50 mM | 0.0234 mL | 0.1169 mL | 0.2339 mL | 0.4678 mL | 0.5847 mL |
| 100 mM | 0.0117 mL | 0.0585 mL | 0.1169 mL | 0.2339 mL | 0.2924 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation.[Pubmed:2026554]
J Antibiot (Tokyo). 1991 Mar;44(3):288-92.
The structure of a new antibiotic designated Lydicamycin was elucidated as shown in Fig. 1 by NMR spectral analysis including a variety of 2D techniques. Lydicamycin possesses a novel skeleton containing tetramic acid and amidinopyrrolidine moieties.
TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598.[Pubmed:12523820]
J Antibiot (Tokyo). 2002 Oct;55(10):873-80.
In screening for anti-MRSA antibiotics, novel Lydicamycin congeners, TPU-0037-A, B, C and D, were isolated from a culture broth of an actinomycete strain. The producing strain, TP-A0598, was isolated from a seawater sample collected in Toyama Bay, Japan, and identified as Streptomyces platensis based on taxonomic characteristics. TPU-0037-A, B, C and D were purified by HP-20 resin, ODS column chromatographies and preparative HPLC, consecutively, and their structures were determined to be 30-demethylLydicamycin, 14,15-dehydro-8-deoxyLydicamycin, 30-demethyl-8-deoxyLydicamycin and 8-deoxyLydicamycin, respectively, by NMR and MS analyses. The new congeners showed antibiotic activity against gram-positive bacteria including MRSA with the MIC of 1.56 to approximately 12.5 microg/ml.
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