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Methyl isodrimeninol

CAS# 442851-27-6

Methyl isodrimeninol

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Methyl isodrimeninol: 5mg $799 In Stock
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Quality Control of Methyl isodrimeninol

Number of papers citing our products

Chemical structure

Methyl isodrimeninol

3D structure

Chemical Properties of Methyl isodrimeninol

Cas No. 442851-27-6 SDF Download SDF
PubChem ID 91885055 Appearance Oil
Formula C16H26O2 M.Wt 250.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,5aS,9aS,9bR)-1-methoxy-6,6,9a-trimethyl-1,3,5,5a,7,8,9,9b-octahydrobenzo[e][2]benzofuran
SMILES CC1(CCCC2(C1CC=C3C2C(OC3)OC)C)C
Standard InChIKey ZRMYQEWJUHSZKS-NHIYQJMISA-N
Standard InChI InChI=1S/C16H26O2/c1-15(2)8-5-9-16(3)12(15)7-6-11-10-18-14(17-4)13(11)16/h6,12-14H,5,7-10H2,1-4H3/t12-,13+,14+,16-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Methyl isodrimeninol

The herbs of Polygonum flaccidum Meissn.

Biological Activity of Methyl isodrimeninol

DescriptionStandard reference
In vitro

Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action[Reference: WebLink]

Bioorganic & Medicinal Chemistry Letters,2002,12(3): 477–482.

The methanolic extract from the leaves of Tasmannia lanceolata was found to potently inhibit ethanol-induced gastric lesions in rats.
METHODS AND RESULTS:
Through bioassay-guided separation, three known sesquiterpenes, polygodial, polygodial 12α-acetal, and polygodial 12β-acetal, and a new sesquiterpene, Methyl isodrimeninol, were isolated as the active constituents. Among them, polygodial showed very potent gastroprotective effects (ED50=0.028 mg/kg, po). From the gastroprotective effects of various reduction and oxidation derivatives of polygodial, the dialdehyde or diacetal structure was found to be essential for the strong activity.
CONCLUSIONS:
Since the gastroprotection of polygodial was attenuated by pretreatment with indomethacin, N-ethylmaleimide, NG-nitro-l-arginine methyl ester and ruthenium red, endogenous prostaglandins, sulfhydryl compounds, nitric oxide and vanilloid receptors may be involved in the protective activity.

Methyl isodrimeninol Dilution Calculator

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Methyl isodrimeninol Molarity Calculator

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Preparing Stock Solutions of Methyl isodrimeninol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9936 mL 19.9681 mL 39.9361 mL 79.8722 mL 99.8403 mL
5 mM 0.7987 mL 3.9936 mL 7.9872 mL 15.9744 mL 19.9681 mL
10 mM 0.3994 mL 1.9968 mL 3.9936 mL 7.9872 mL 9.984 mL
50 mM 0.0799 mL 0.3994 mL 0.7987 mL 1.5974 mL 1.9968 mL
100 mM 0.0399 mL 0.1997 mL 0.3994 mL 0.7987 mL 0.9984 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Methyl isodrimeninol

Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action.[Pubmed:11814823]

Bioorg Med Chem Lett. 2002 Feb 11;12(3):477-82.

The methanolic extract from the leaves of Tasmannia lanceolata was found to potently inhibit ethanol-induced gastric lesions in rats. Through bioassay-guided separation, three known sesquiterpenes, polygodial, polygodial 12 alpha-acetal, and polygodial 12 beta-acetal, and a new sesquiterpene, Methyl isodrimeninol, were isolated as the active constituents. Among them, polygodial showed very potent gastroprotective effects (ED(50)=0.028 mg/kg, po). From the gastroprotective effects of various reduction and oxidation derivatives of polygodial, the dialdehyde or diacetal structure was found to be essential for the strong activity. Since the gastroprotection of polygodial was attenuated by pretreatment with indomethacin, N-ethylmaleimide, N(G)-nitro-L-arginine methyl ester and ruthenium red, endogenous prostaglandins, sulfhydryl compounds, nitric oxide and vanilloid receptors may be involved in the protective activity.

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