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BC 11 hydrobromide

Selective urokinase inhibitor CAS# 443776-49-6

BC 11 hydrobromide

Catalog No. BCC2381----Order now to get a substantial discount!

Product Name & Size Price Stock
BC 11 hydrobromide: 5mg $104 In Stock
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Quality Control of BC 11 hydrobromide

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Chemical structure

BC 11 hydrobromide

3D structure

Chemical Properties of BC 11 hydrobromide

Cas No. 443776-49-6 SDF Download SDF
PubChem ID 78243712 Appearance Powder
Formula C8H12BBrN2O2S M.Wt 290.97
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
Chemical Name [4-(carbamimidoylsulfanylmethyl)phenyl]boronic acid;hydrobromide
SMILES B(C1=CC=C(C=C1)CSC(=N)N)(O)O.Br
Standard InChIKey PAFZAMOVHIRQOD-UHFFFAOYSA-N
Standard InChI InChI=1S/C8H11BN2O2S.BrH/c10-8(11)14-5-6-1-3-7(4-2-6)9(12)13;/h1-4,12-13H,5H2,(H3,10,11);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of BC 11 hydrobromide

DescriptionSelective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

BC 11 hydrobromide Dilution Calculator

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BC 11 hydrobromide Molarity Calculator

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Preparing Stock Solutions of BC 11 hydrobromide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4368 mL 17.1839 mL 34.3678 mL 68.7356 mL 85.9195 mL
5 mM 0.6874 mL 3.4368 mL 6.8736 mL 13.7471 mL 17.1839 mL
10 mM 0.3437 mL 1.7184 mL 3.4368 mL 6.8736 mL 8.592 mL
50 mM 0.0687 mL 0.3437 mL 0.6874 mL 1.3747 mL 1.7184 mL
100 mM 0.0344 mL 0.1718 mL 0.3437 mL 0.6874 mL 0.8592 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on BC 11 hydrobromide

Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation.

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References on BC 11 hydrobromide

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells.[Pubmed:26029857]

Molecules. 2015 May 28;20(6):9879-89.

BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 muM). Exposure of cells to BC-11, either pre-absorbed with a soluble preparation of the N-terminal fragment of urokinase-plasminogen activator (uPa), or in co-treatment with two different EGFR inhibitors, indicated that: (i) BC-11 acts via binding to the N-terminus of the enzyme where uPa- and EGF receptor-recognizing sites are present, thereby abrogating the growth-sustaining effect resulting from receptor binding; and (ii) the co-presence of the EGFR inhibitor PD153035 potentiates BC-11's cytotoxicity. Exposure of cells to a higher concentration of BC-11 corresponding to its ED75 at 72 h (250 muM) caused additional impairment of mitochondrial activity, the production of reactive oxygen species and promotion of apoptosis. Therefore, BC-11 treatment appears to show potential for the development of this class of compounds in the prevention and/or therapy of "aggressive" breast carcinoma.

Description

Selective urokinase (uPA) inhibitor

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