Mexoticin

A Simple and Efficient Two-Dimensional High-Speed Counter-Current Chromatography Linear Gradient and Isocratic Elution Modes for the Preparative Separation of Coumarins from Roots of Toddalia asiatica (Linn.) Lam.[Pubmed:34641527]

Molecules. 2021 Oct 2;26(19):5986.

Toddalia asiatica (L.) Lam. (Rutaceae) has shown a broad spectrum of biological properties, such as anti-inflammatory, antioxidant, antimicrobial, anti-HIV, and anticancer properties. The present study is concerned with the separation of the main components with broad partition coefficients (K(D) values) from T. asiatica, using linear gradient high-speed counter-current chromatography (LGCCC) combined with an off-line two-dimensional (2D) mode. Similar to the binary gradient HPLC, the LGCCC mode is operated by the adjustment of the proportion between the mobile phase of 5:5:1:9 (v/v) (pump A) and 5:5:4.5:5.5 (v/v) (pump B) in an n-hexane/ethyl acetate/methanol/water solvent system. The off-line 2D-CCC mode was used in this study for the secondary separation of two similar K(D) value compounds with n-hexane/ethyl acetate/methanol/water (5:5:4:6, v/v). Notably, six coumarins, namely, tomentin (1), toddalolactone (2), 5,7,8-trimethoxycoumarin (3), Mexoticin (4), isopimpinellin (5), and toddanone (6), were efficiently separated. The structures of the pure compounds were elucidated by spectral techniques and compared with the literature.

Coumarins from Murraya paniculata var. zollingeri endemic to the Timor Islands.[Pubmed:25920269]

Nat Prod Commun. 2015 Feb;10(2):309-12.

Four new coumarins, murrangatin-1'-senecioate (1), 5-methoxypanial (2), Mexoticin-2'-senecioate (3) and murralongic acid (4), were isolated from the leaves of Murraya paniculata var. zollingeri, together with 23 known coumarins. The structures of the new compounds were elucidated based on spectroscopic data. The taxonomic status of M. paniculata var. zollingeri is briefly discussed, along with its similarity to M. paniculata.

[Studies on chemical constituents of Peucedanum delavayi].[Pubmed:19112893]

Zhong Yao Cai. 2008 Aug;31(8):1157-9.

OBJECTIVE: To study the chemical constituents of the radix and rhizome of Peucedanum delavayi. METHODS: The chemical constituents had been separated by manifold chromato-graphy methods, and their structures were determined by spectral analysis. RESULTS: Fifteen compounds were isolated and identified as Umbelliferone(I), Coumurayin(II), Mexoticin(III), Marmesin (IV), Ammijin(V), Delton (VI), Selinidin(VII), Anomalin(VII), Isopteryxin(IX), Ferulic acid(X), Falcarindiol(XI), Stearic acid(XII), beta-sitosterol(X III), Daucosterol(XIV) and d-Mannitol(XV). CONCLUSION: All these compounds are isolated from Peucedanum delavayi for the first time.

A new bicoumarin from the leaves and stems of Triphasia trifolia.[Pubmed:16431036]

Fitoterapia. 2006 Feb;77(2):129-33.

A new bicoumarin (3) was isolated from the leaves and stems of Triphasia trifolia. Its structure was determined by spectral data, in particular two-dimensional NMR experiments. It appeared that the two coumarinic moieties of 3 are derivatives of Mexoticin (1) and meranzin hydrate (2), which are known constituents of the plant.

Bioactive coumarins from the leaves of Murraya omphalocarpa.[Pubmed:12898423]

Planta Med. 2003 Jul;69(7):654-7.

Using antiplatelet aggregation as a guide to fractionation, eight coumarins, omphalocarpinol (1), 5,7-dimethoxy-8-(3'-methyl-2'-oxobutyl)coumarin (2), murralongin, murrayanone, omphamurin (5), murragleinin, Mexoticin, and murrangatin, were isolated from the leaves of Murraya omphalocarpa. Compound 1 is new, and 5 is a new enantiomer of omphamurin. The structures of these compounds were elucidated on the basis of spectroscopic techniques, and the structure of compound 1 was confirmed by X-ray crystallographic analysis. Among them, compounds 1, 2 and 5 exhibited significant antiplatelet aggregation activity.