Morusalnol B

Name: Morusalnol B
Brand: BioCrick
SKU: BCX2422

CAS# 1941207-44-8

Morusalnol B 2D chemical structure

2D Structure

Catalog No. BCX2422----Order now to get a substantial discount!

Product Name & Size	Price	Stock
Morusalnol B: 5mg	Please Inquire	In Stock
Morusalnol B: 10mg	Please Inquire	In Stock
Morusalnol B: 20mg	Please Inquire	Please Inquire
Morusalnol B: 50mg	Please Inquire	Please Inquire
Morusalnol B: 100mg	Please Inquire	Please Inquire
Morusalnol B: 200mg	Please Inquire	Please Inquire
Morusalnol B: 500mg	Please Inquire	Please Inquire
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Chemical Properties of Morusalnol B

Cas No.	1941207-44-8	SDF	File under preparation.
PubChem ID	N/A	Appearance	Powder
Formula	C25H26O6	M.Wt	422.5
Type of Compound	N/A	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Quality Control of Morusalnol B

Quality Control & MSDS

Purity: >98%

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Morusalnol B Dilution Calculator

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Preparing Stock Solutions of Morusalnol B

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3669 mL	11.8343 mL	23.6686 mL	47.3373 mL	59.1716 mL
5 mM	0.4734 mL	2.3669 mL	4.7337 mL	9.4675 mL	11.8343 mL
10 mM	0.2367 mL	1.1834 mL	2.3669 mL	4.7337 mL	5.9172 mL
50 mM	0.0473 mL	0.2367 mL	0.4734 mL	0.9467 mL	1.1834 mL
100 mM	0.0237 mL	0.1183 mL	0.2367 mL	0.4734 mL	0.5917 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on Morusalnol B

Inhibition of PTP1B by farnesylated 2-arylbenzofurans isolated from Morus alba root bark: unraveling the mechanism of inhibition based on in vitro and in silico studies.[Pubmed:32978714]

Arch Pharm Res. 2020 Sep;43(9):961-975.

Among the 2-arylbenzofuran derivatives isolated from Morus alba, the farnesylated 2-arylbenzofuran is a rarer constituent. The derivative has been reported to exert anti-obesity effect; however, its inhibitory effect on protein tyrosine phosphatase 1B (PTP1B) has not been investigated. In the previous study, the presence of the farnesyl group in the structure of 2-arylbenzofurans was found to have positive influences on their pancreatic lipase inhibitory activity. In the present study, we have confirmed the authenticity of the notation based on the PTP1B inhibitory activity of farnesylated 2-arylbenzofurans. Specifically, two farnesylated 2-arylbenzofurans [morusalfurans B (2) and C (3)] showed strong inhibitory effects on PTP1B with IC(50) values of 8.92 and 7.26 microM, respectively, which was significantly higher than that of the positive controls [sodium orthovanadate (IC(50) = 15.10 microM) and ursolic acid (IC(50) = 11.34 microM)]. Besides, two 2-arylbenzofurans [morusalfurans A (1) and F (6)], one flavonoid [Morusalnol B (9)], and one geranylated stilbene [morusibene A (11)] exhibited PTP1B inhibition with IC(50) values ranging from 11.02 to 26.56 microM. Kinetic studies revealed compounds 2, 3, 6, and 11 as mixed type PTP1B inhibitors, while 1 and 9 are known as noncompetitive. Molecular docking simulations demonstrated that these active compounds can bind with the respective catalytic or/and allosteric sites of PTP1B with negative binding energies and the results are in accordance with that of the kinetic studies. To the best of our knowledge, this is the first time, the PTP1B inhibitory activity of eleven compounds (1-11), as well as the mechanism of action underlying the effects on PTP1B enzyme of the active compounds, were investigated. In vitro and in silico results suggest that the farnesylated 2-arylbenzofurans from M. alba may potentially be utilized as an effective treatment therapy for type 2 diabetes mellitus and its associated complications.

Product Information

Morusalnol B (CAS 1941207-44-8) is a natural product offered by BioCrick for research applications. Customers can buy or order Morusalnol B from BioCrick, a supplier and manufacturer of research chemicals, with product specifications, purity, packaging, and pricing information available upon request.