NeogrifolinCAS# 23665-96-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 23665-96-5 | SDF | Download SDF |
PubChem ID | 9874426 | Appearance | Powder |
Formula | C22H32O2 | M.Wt | 328.49 |
Type of Compound | Phenols | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 5-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol | ||
SMILES | CC1=CC(=CC(=C1CC=C(C)CCC=C(C)CCC=C(C)C)O)O | ||
Standard InChIKey | JWDIUXFSIWOGDP-VZRGJMDUSA-N | ||
Standard InChI | InChI=1S/C22H32O2/c1-16(2)8-6-9-17(3)10-7-11-18(4)12-13-21-19(5)14-20(23)15-22(21)24/h8,10,12,14-15,23-24H,6-7,9,11,13H2,1-5H3/b17-10+,18-12+ | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines. 2. Neogrifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, the MIC values of 20 and 0.5 microg/mL, respectively. 3. Neogrifolin exhibits inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with the IC50value of 23.3 microM. |
Targets | PARP | Caspase | Akt | GSK-3 | NO |
Neogrifolin Dilution Calculator
Neogrifolin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.0442 mL | 15.2212 mL | 30.4423 mL | 60.8847 mL | 76.1058 mL |
5 mM | 0.6088 mL | 3.0442 mL | 6.0885 mL | 12.1769 mL | 15.2212 mL |
10 mM | 0.3044 mL | 1.5221 mL | 3.0442 mL | 6.0885 mL | 7.6106 mL |
50 mM | 0.0609 mL | 0.3044 mL | 0.6088 mL | 1.2177 mL | 1.5221 mL |
100 mM | 0.0304 mL | 0.1522 mL | 0.3044 mL | 0.6088 mL | 0.7611 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Ardisiacrispin A
Catalog No.:BCN2323
CAS No.:23643-61-0
- Clerosterol
Catalog No.:BCN2905
CAS No.:2364-23-0
- Triapine
Catalog No.:BCC5112
CAS No.:236392-56-6
- Z-Asp(OtBu)-OH.DCHA
Catalog No.:BCC2788
CAS No.:23632-70-4
- Boldenone acetate
Catalog No.:BCC8893
CAS No.:2363-59-9
- Kaempferol-3-O-galactoside
Catalog No.:BCN3061
CAS No.:23627-87-4
- Putraflavone
Catalog No.:BCN5089
CAS No.:23624-21-7
- HOE 33187
Catalog No.:BCC1622
CAS No.:23623-08-7
- HOE 32021
Catalog No.:BCC1621
CAS No.:23623-06-5
- [Arg14,Lys15]Nociceptin
Catalog No.:BCC5781
CAS No.:236098-40-1
- H-Phe-pNA
Catalog No.:BCC3010
CAS No.:2360-97-6
- Norisoboldine
Catalog No.:BCN6285
CAS No.:23599-69-1
- Vicenin -2
Catalog No.:BCN3013
CAS No.:23666-13-9
- Stigmast-4-ene-3,6-dione
Catalog No.:BCN5778
CAS No.:23670-94-2
- Levosulpiride
Catalog No.:BCC4463
CAS No.:23672-07-3
- Boc-Ser(Bzl)-OH
Catalog No.:BCC3442
CAS No.:23680-31-1
- Olaquindox
Catalog No.:BCN2538
CAS No.:23696-28-8
- Damascenone
Catalog No.:BCN8355
CAS No.:23696-85-7
- Platycoside E
Catalog No.:BCN6385
CAS No.:237068-41-6
- Nardosinone
Catalog No.:BCN2324
CAS No.:23720-80-1
- Chebulic acid
Catalog No.:BCN3260
CAS No.:23725-05-5
- 6-Hydroxy-4-Methylcoumarin
Catalog No.:BCC9206
CAS No.:2373-31-1
- trans-Methylkhellactone
Catalog No.:BCN6919
CAS No.:23733-92-8
- trans-3'-O-Benzoyl-4'-O-methylkhellactone
Catalog No.:BCN6921
CAS No.:23733-95-1
Apoptosis prediction via inhibition of AKT signaling pathway by neogrifolin.[Pubmed:25973001]
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1154-64. eCollection 2015.
Neogrifolin, a natural biologically active substance isolated from the edible bodies of the mushroom Albatrellus confluens, has been shown to possess several pharmacological properties. No studies were investigated against osteosarcoma cancer. Hence, in this study, we investigated the apoptosis-inducing effects and the mechanisms of Neogrifolin on human osteosarcoma cells. Our results demonstrated that Neogrifolin induced concentration- and time-dependent suppression of proliferation. Further, induction of apoptosis in U2OS and MG63 osteosarcoma cell lines were also observed. Neogrifolin induced the release of cytochrome c accompanied by activation of caspase-9, caspase-3 and cleavage of poly (ADP-ribose) polymerase (PARP). In addition, z-VAD-fmk, a universal inhibitor of caspases, prevented caspase-3 activation and PARP cleavage and inhibited Neogrifolin-induced cell growth inhibition. Furthermore, Neogrifolin treatment resulted in a reduction of phosphorylated AKT level, FOXO transcription factor, and glycogen synthase kinase 3 (GSK3). Knockdown of GSK3 with siRNA inhibited the apoptotic effects of Neogrifolin. On the other hand, Neogrifolin treatment also down-regulated the expression of the inhibitor of apoptosis protein (IAP) in both osteosarcoma cells. Collectively, our results suggested that Neogrifolin is a potential candidate for osteosarcoma.
Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis.[Pubmed:19644795]
Planta Med. 2010 Feb;76(2):182-5.
Antibacterial bioassay-guided fractionation of two American mushroom species, Jahnoporus hirtus and Albatrellus flettii, led to the isolation and identification of their major antibacterial constituents: 3,11-dioxolanosta-8,24( Z)-diene-26-oic acid (1) from J. hirtus and confluentin (2), grifolin (3), and Neogrifolin (4) from A. flettii. Compound 1 is a new lanostane-type triterpene. All purified compounds were evaluated for their ability to inhibit the growth of Bacillus cereus and Enterococcus faecalis using standard MIC assays. Compounds 1- 4 demonstrated MIC values of 40, 20, 10, and 20 microg/mL, respectively, against B. cereus and MIC values of 32, 1.0, 0.5, and 0.5 microg/mL, respectively, against E. faecalis. Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.
Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells.[Pubmed:16169234]
Bioorg Med Chem. 2006 Jan 1;14(1):164-8.
Two new farnesyl phenols named grifolinones A and B, together with known grifolin and Neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin molecules, which were connected by a C-C bond. Grifolinones A and B, grifolin, and Neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50values of 23.4, 22.9, 29.0, and 23.3 microM, respectively.