Home >> Research Area >>Natural Products>>Alkaloids>> Neoligularidine

Neoligularidine

CAS# 90364-91-3

Neoligularidine

Catalog No. BCN2137----Order now to get a substantial discount!

Product Name & Size Price Stock
Neoligularidine: 5mg Please Inquire In Stock
Neoligularidine: 10mg Please Inquire In Stock
Neoligularidine: 20mg Please Inquire Please Inquire
Neoligularidine: 50mg Please Inquire Please Inquire
Neoligularidine: 100mg Please Inquire Please Inquire
Neoligularidine: 200mg Please Inquire Please Inquire
Neoligularidine: 500mg Please Inquire Please Inquire
Neoligularidine: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Neoligularidine

Number of papers citing our products

Chemical structure

Neoligularidine

3D structure

Chemical Properties of Neoligularidine

Cas No. 90364-91-3 SDF Download SDF
PubChem ID 6440920 Appearance Cryst.
Formula C21H29NO7 M.Wt 407.46
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1R,4Z,6R,7S,11Z)-4-ethylidene-6,7,14-trimethyl-3,8,17-trioxo-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-en-7-yl] acetate
SMILES CC=C1CC(C(C(=O)OCC2=CCN(CCC(C2=O)OC1=O)C)(C)OC(=O)C)C
Standard InChIKey ZOIAVVNLMDKOIV-JNNPZHNTSA-N
Standard InChI InChI=1S/C21H29NO7/c1-6-15-11-13(2)21(4,29-14(3)23)20(26)27-12-16-7-9-22(5)10-8-17(18(16)24)28-19(15)25/h6-7,13,17H,8-12H2,1-5H3/b15-6-,16-7-/t13-,17-,21+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Neoligularidine

DescriptionNeoligularidine is a natural product from Ligularia dentata.

Protocol of Neoligularidine

Structure Identification
Chemical & Pharmaceutical Bulletin, 1984 , 32 (2) :475-482.

Studies on Constituents of Crude Drugs. XV. New Pyrrolizidine Alkaloids from Ligularia dentata[Reference: WebLink]


METHODS AND RESULTS:
Four new pyrrolizidine alkaloids, ligularidine, Neoligularidine, ligularizine and ligularinine, were isolated together with the known compound clivorine from the roots and aerial parts of Ligularia dentata. Their structures were elucidated on the basis of the spectral data and chemical conversion of clivorine into these alkaloids.
CONCLUSIONS:
A useful epoxidation of pyrrolizidine alkaloids was achieved by using performic acid.

J Chromatogr A. 2004 Nov 12;1056(1-2):91-7.

On-line structure characterization of pyrrolizidine alkaloids in Onosma stellulatum and Emilia coccinea by liquid chromatography–ion-trap mass spectrometry[Pubmed: 15595537]

On-line structure characterization of pyrrolizidine alkaloids in two various plant species (Onosma stellulatum W.K., family Boraginaceae and Emilia coccinea Sims., family Compositae) was performed by a newly elaborated RP-HPLC ion trap MS method with atmospheric pressure chemical ionization (APCI) interface.
METHODS AND RESULTS:
Different PAs (N-oxides, free bases, otonecine alkaloids) isolated were separated on Waters XTerra C18 column using a gradient elution. The combination of a CE-SPE with multiple isolation and fragmentation steps for specific masses in ion trap MS detector enabled fast and sensitive analysis of various types of PAs (N-oxides and free bases). In O. stellulatum, spectra 12 various types of structures (13 different alkaloids) have been determined for the first time: leptanthine-N-oxide, lycopsamine-N-oxide, heliospathuline, lycopsamine, trachelanthamine-N-oxide, dihydroechinatine, leptanthine, heliospathuline-N-oxide, 7-acetylintermedine, uplandicine, echimidine and echimidine-N-oxide. In E. coccinea, the following types of PAs were found: platyphylline-N-oxide, platyphylline (three stereoisomers with the same MS(n) spectrum), ligularidine, Neoligularidine, neosenkirkine and also previously reported senkirkine.
CONCLUSIONS:
The method elaborated can be applied in the structural analysis of PAs in newly examined plant materials or food products but further analysis is needed to determine the stereochemistry in details.

Neoligularidine Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Neoligularidine Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Neoligularidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4542 mL 12.2711 mL 24.5423 mL 49.0846 mL 61.3557 mL
5 mM 0.4908 mL 2.4542 mL 4.9085 mL 9.8169 mL 12.2711 mL
10 mM 0.2454 mL 1.2271 mL 2.4542 mL 4.9085 mL 6.1356 mL
50 mM 0.0491 mL 0.2454 mL 0.4908 mL 0.9817 mL 1.2271 mL
100 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.4908 mL 0.6136 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Neoligularidine

On-line structure characterization of pyrrolizidine alkaloids in Onosma stellulatum and Emilia coccinea by liquid chromatography-ion-trap mass spectrometry.[Pubmed:15595537]

J Chromatogr A. 2004 Nov 12;1056(1-2):91-7.

On-line structure characterization of pyrrolizidine alkaloids in two various plant species (Onosma stellulatum W.K., family Boraginaceae and Emilia coccinea Sims., family Compositae) was performed by a newly elaborated RP-HPLC ion trap MS method with atmospheric pressure chemical ionization (APCI) interface. Different PAs (N-oxides, free bases, otonecine alkaloids) isolated were separated on Waters XTerra C18 column using a gradient elution. The combination of a CE-SPE with multiple isolation and fragmentation steps for specific masses in ion trap MS detector enabled fast and sensitive analysis of various types of PAs (N-oxides and free bases). In O. stellulatum, spectra 12 various types of structures (13 different alkaloids) have been determined for the first time: leptanthine-N-oxide, lycopsamine-N-oxide, heliospathuline, lycopsamine, trachelanthamine-N-oxide, dihydroechinatine, leptanthine, heliospathuline-N-oxide, 7-acetylintermedine, uplandicine, echimidine and echimidine-N-oxide. In E. coccinea, the following types of PAs were found: platyphylline-N-oxide, platyphylline (three stereoisomers with the same MS(n) spectrum), ligularidine, Neoligularidine, neosenkirkine and also previously reported senkirkine. The method elaborated can be applied in the structural analysis of PAs in newly examined plant materials or food products but further analysis is needed to determine the stereochemistry in details.

Keywords:

Neoligularidine,90364-91-3,Natural Products, buy Neoligularidine , Neoligularidine supplier , purchase Neoligularidine , Neoligularidine cost , Neoligularidine manufacturer , order Neoligularidine , high purity Neoligularidine

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: