FPA 124

Akt/PKB inhibitor CAS# 902779-59-3

FPA 124

Catalog No. BCC7518----Order now to get a substantial discount!

Product Name & Size Price Stock
FPA 124: 5mg $104 In Stock
FPA 124: 10mg Please Inquire In Stock
FPA 124: 20mg Please Inquire Please Inquire
FPA 124: 50mg Please Inquire Please Inquire
FPA 124: 100mg Please Inquire Please Inquire
FPA 124: 200mg Please Inquire Please Inquire
FPA 124: 500mg Please Inquire Please Inquire
FPA 124: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of FPA 124

Number of papers citing our products

Chemical structure

FPA 124

3D structure

Chemical Properties of FPA 124

Cas No. 902779-59-3 SDF Download SDF
PubChem ID 16034833 Appearance Powder
Formula C11H9Cl2CuN3O2S M.Wt 381.73
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 10 mM in DMSO and to 10 mM in ethanol
Chemical Name dichlorocopper;[(E)-(4-oxochromen-3-yl)methylideneamino]thiourea
SMILES C1=CC=C2C(=C1)C(=O)C(=CO2)C=NNC(=S)N.Cl[Cu]Cl
Standard InChIKey HZRXQEVFXXQYFS-VBPDOGLUSA-L
Standard InChI InChI=1S/C11H9N3O2S.2ClH.Cu/c12-11(17)14-13-5-7-6-16-9-4-2-1-3-8(9)10(7)15;;;/h1-6H,(H3,12,14,17);2*1H;/q;;;+2/p-2/b13-5+;;;
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of FPA 124

DescriptionAkt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

FPA 124 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

FPA 124 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of FPA 124

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6197 mL 13.0983 mL 26.1965 mL 52.3931 mL 65.4913 mL
5 mM 0.5239 mL 2.6197 mL 5.2393 mL 10.4786 mL 13.0983 mL
10 mM 0.262 mL 1.3098 mL 2.6197 mL 5.2393 mL 6.5491 mL
50 mM 0.0524 mL 0.262 mL 0.5239 mL 1.0479 mL 1.3098 mL
100 mM 0.0262 mL 0.131 mL 0.262 mL 0.5239 mL 0.6549 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on FPA 124

Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.[Pubmed:16789737]

J Med Chem. 2006 Jun 29;49(13):3800-8.

The synthesis and characterization of Schiff base derivatives of 3-formylchromone 3-6 (FPA-120 to FPA-123), the minimal biologically active structural motif of soy isoflavone, genistein, and their copper(II) complexes 7-10 (FPA-124 to FPA-127) are reported here. These copper complexes possess distorted square-planar geometries capable of stabilizing Cu2+/Cu+ redox forms. The molecular modeling study revealed that the key interaction of the metal complexes was with amino acids in the pleckstrin homology (PH) and the kinase domain of the PKB (Akt) protein. Copper complex 7 significantly forms stronger charge interactions in the kinase domain than genistein, leading to better stabilization in the active pocket. In vitro evaluation of copper complexes against hormone-independent and metastatic breast (BT20), prostate (PC-3), and K-ras mutant (COLO 357) and K-ras wild-type (BxPC-3) pancreatic cancer cells revealed that 7 was the most potent compound which exhibited PKB (Akt protein) inhibitory activities and caused NF-kappaB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells. An inverse relationship was observed between IC50 values of the anti-proliferative activities and the Cu2+/Cu+ redox couple for these compounds, which may provide a rapid screen for evaluating the efficacy of active metallodrugs affecting redox-sensitive transcription factors such as NF-kappaB and its upstream target, the PKB (Akt) pathway, in multiple cancers.

Description

FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis.

Keywords:

FPA 124,902779-59-3,Natural Products,Akt, buy FPA 124 , FPA 124 supplier , purchase FPA 124 , FPA 124 cost , FPA 124 manufacturer , order FPA 124 , high purity FPA 124

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: