NiazininCAS# 147821-57-6 |
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| Cas No. | 147821-57-6 | SDF | Download SDF |
| PubChem ID | 10088810 | Appearance | Oil |
| Formula | C15H21NO6S | M.Wt | 343.39 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | O-methyl N-[[4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphenyl]methyl]carbamothioate | ||
| SMILES | CC1C(C(C(C(O1)OC2=CC=C(C=C2)CNC(=S)OC)O)O)O | ||
| Standard InChIKey | ZOIAMMQYAZSWRX-CNJBRALLSA-N | ||
| Standard InChI | InChI=1S/C15H21NO6S/c1-8-11(17)12(18)13(19)14(21-8)22-10-5-3-9(4-6-10)7-16-15(23)20-2/h3-6,8,11-14,17-19H,7H2,1-2H3,(H,16,23)/t8-,11-,12+,13+,14-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The leaves of Moringa oleifera Lam.
| Description | 1. Niazinin shows antileishmanial activity against promastigotes of Leishmania donavani, with an IC50 value of 5.25 microM. |
| Targets | Antifection |
Niazinin Dilution Calculator
Niazinin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9121 mL | 14.5607 mL | 29.1214 mL | 58.2428 mL | 72.8035 mL |
| 5 mM | 0.5824 mL | 2.9121 mL | 5.8243 mL | 11.6486 mL | 14.5607 mL |
| 10 mM | 0.2912 mL | 1.4561 mL | 2.9121 mL | 5.8243 mL | 7.2804 mL |
| 50 mM | 0.0582 mL | 0.2912 mL | 0.5824 mL | 1.1649 mL | 1.4561 mL |
| 100 mM | 0.0291 mL | 0.1456 mL | 0.2912 mL | 0.5824 mL | 0.728 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antileishmanial compounds from Moringa oleifera Lam.[Pubmed:24873031]
Z Naturforsch C. 2014 Mar-Apr;69(3-4):110-6.
The antileishmanial activity of extracts and phytoconstituents of Moringa oleifera Lam. was investigated in vitro against promastigotes of Leishmania donavani. The 70% ethanolic extract of roots and the methanolic extract of leaves showed moderate inhibitory activity with IC50 values of 83.0 microg/ml and 47.5 microg/ml, respectively. Antileishmanial activity of the methanolic extract of leaves increased upon fractionation, as its ethyl acetate fraction was found to be more active with an IC50 value of 27.5 microg/ml. The most active antileishmanial compound Niazinin, a thiocarbamate glycoside isolated from this fraction, showed an IC50 value of 5.25 microM. Results presented in this study indicate that extracts from M. oleifera may be developed as an adjuvant therapy for the treatment of leishmaniasis.
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