DinitolmideCAS# 148-01-6 |
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| Cas No. | 148-01-6 | SDF | Download SDF |
| PubChem ID | 3092 | Appearance | Powder |
| Formula | C8H7N3O5 | M.Wt | 225 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 49 mg/mL (217.62 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-methyl-3,5-dinitrobenzamide | ||
| SMILES | CC1=C(C=C(C=C1C(=O)N)[N+](=O)[O-])[N+](=O)[O-] | ||
| Standard InChIKey | ZEFNOZRLAWVAQF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Dinitolmide Dilution Calculator
Dinitolmide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.4444 mL | 22.2222 mL | 44.4444 mL | 88.8889 mL | 111.1111 mL |
| 5 mM | 0.8889 mL | 4.4444 mL | 8.8889 mL | 17.7778 mL | 22.2222 mL |
| 10 mM | 0.4444 mL | 2.2222 mL | 4.4444 mL | 8.8889 mL | 11.1111 mL |
| 50 mM | 0.0889 mL | 0.4444 mL | 0.8889 mL | 1.7778 mL | 2.2222 mL |
| 100 mM | 0.0444 mL | 0.2222 mL | 0.4444 mL | 0.8889 mL | 1.1111 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effect of Cocciban herbal coccidiostats on hematobiochemical, fecal parameters and cecal histopathology of broiler chicken.[Pubmed:30729387]
Trop Anim Health Prod. 2019 Feb 7. pii: 10.1007/s11250-019-01831-3.
The objective of the present study was to investigate the comparative efficacy of recommended dose of selected anticoccidial drugs Salinomycin and Dinitolmide, while Cocciban at three dose levels on the hematobiochemical, fecal parameters and histopathology of broilers. For this purpose, 420-day-old commercial male broiler chicks were randomly divided into 7 treatment groups with 10 replications of 6 birds each and reared in battery brooders up to 42 days of age. Groups were designated as uninfected unmedicated (T1), infected unmedicated (T2), Cocciban 500 g/ton and infected (T3), Cocciban 750 g/ton and infected (T4), Cocciban 1000 g/ton and infected (T5), Salinomycin 500 g/ton and infected (T6), and Dinitolmide and infected (T7). Groups T2, T3, T4, T5, T6, and T7 were experimentally infected at 21-day-old by 50,000 oocysts of Eimeria species. The mean fecal, lesion scores and oocyst per gram of feces were significantly (p < 0.05) highest in infected unmedicated group, while lowest in the herbal Cocciban 1000 g/ton group than all other infected medicated groups. The hematological studies revealed a reduction in TEC, Hb, and PCV from 0 to 5th day of P.I. in all infected groups except healthy control group. The birds of all the infected groups improved in the values of TEC, Hb, PCV, blood glucose, and total serum protein on 7th day of P.I., but, the improvement was significantly (p < 0.05) better in herbal Cocciban 1000 g/ton treated birds than all other infected groups. Whereas, the TWBC counts were raised from 0 to 7th day of P.I. in all the infected groups compared to healthy control and no significant (p < 0.05) difference was observed in between the infected groups. The histopathological changes consisting of desquamation of epithelial cells, cellular infiltration, hemorrhages, edema, fibrous tissue proliferation, and developing stages of E. tenella at various depths of cecal wall were higher in all the infected groups when compared to Cocciban 1000 g/ton group.
Ultrastructural studies of the effects of amprolium and dinitolmide on Eimeria acervulina macrogametes.[Pubmed:3615394]
Parasitol Res. 1987;73(4):293-7.
Medication of chicks with 125 ppm amprolium or Dinitolmide adversely affected oocyst sporulation of Eimeria acervulina (Weybridge strain). Dinitolmide delayed oocyst production and no oocyst wall formation was seen up to 168 h post infection. Both drugs caused large numbers of abnormally small wall-forming bodies to be produced in the macrogametes. In amprolium-fed chicks, abnormal oocyst wall formation was seen. It was concluded that the main drug action was against wall forming bodies of type 2.
