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Nicotine 1'-N-oxide

CAS# 51095-86-4

Nicotine 1'-N-oxide

Catalog No. BCN6892----Order now to get a substantial discount!

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Quality Control of Nicotine 1'-N-oxide

Number of papers citing our products

Chemical structure

Nicotine 1'-N-oxide

3D structure

Chemical Properties of Nicotine 1'-N-oxide

Cas No. 51095-86-4 SDF Download SDF
PubChem ID 12313859 Appearance Oil
Formula C10H14N2O M.Wt 178.23
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[(1S,2S)-1-methyl-1-oxidopyrrolidin-1-ium-2-yl]pyridine
SMILES C[N+]1(CCCC1C2=CN=CC=C2)[O-]
Standard InChIKey RWFBQHICRCUQJJ-JQWIXIFHSA-N
Standard InChI InChI=1S/C10H14N2O/c1-12(13)7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-,12-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Nicotine 1'-N-oxide

Them tobacco smoke.

Biological Activity of Nicotine 1'-N-oxide

DescriptionNicotine 1'-N-oxide is a natural product from tobacco smoke.

Protocol of Nicotine 1'-N-oxide

Structure Identification
J Chromatogr. 1993 Feb 26;612(2):302-9.

Determination of nicotine and its main metabolites in urine by high-performance liquid chromatography.[Pubmed: 8468389]


METHODS AND RESULTS:
Nicotine and its main metabolites (cotinine, trans-3'-hydroxycotinine, trans-3'-hydroxycotinine glucuronide, Nicotine 1'-N-oxide and 3-pyridylcarbinol) were analysed in urine after liquid-liquid extraction by high-performance liquid chromatography using norephedrine as internal standard, ultraviolet detection at 260 nm and scanning ultraviolet spectra with a photodiode-array detector. The conjugated trans-3'-hydroxycotinine was determined after enzymatic hydrolysis. Specific determination of 3-pyridylcarbinol was also carried out. Owing to its good selectivity, sensitivity and reproducibility, the method was applied to the analysis of urine samples from smokers and non-smokers.
CONCLUSIONS:
The results obtained suggest that the urinary markers used to assess active smoking or exposure to environmental tobacco smoke must be not only nicotine and cotinine, but also their main free and conjugated metabolites.

Nicotine 1'-N-oxide Dilution Calculator

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Nicotine 1'-N-oxide Molarity Calculator

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Preparing Stock Solutions of Nicotine 1'-N-oxide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.6107 mL 28.0536 mL 56.1073 mL 112.2146 mL 140.2682 mL
5 mM 1.1221 mL 5.6107 mL 11.2215 mL 22.4429 mL 28.0536 mL
10 mM 0.5611 mL 2.8054 mL 5.6107 mL 11.2215 mL 14.0268 mL
50 mM 0.1122 mL 0.5611 mL 1.1221 mL 2.2443 mL 2.8054 mL
100 mM 0.0561 mL 0.2805 mL 0.5611 mL 1.1221 mL 1.4027 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Nicotine 1'-N-oxide

Determination of nicotine and its main metabolites in urine by high-performance liquid chromatography.[Pubmed:8468389]

J Chromatogr. 1993 Feb 26;612(2):302-9.

Nicotine and its main metabolites (cotinine, trans-3'-hydroxycotinine, trans-3'-hydroxycotinine glucuronide, nicotine-1'-N-oxide and 3-pyridylcarbinol) were analysed in urine after liquid-liquid extraction by high-performance liquid chromatography using norephedrine as internal standard, ultraviolet detection at 260 nm and scanning ultraviolet spectra with a photodiode-array detector. The conjugated trans-3'-hydroxycotinine was determined after enzymatic hydrolysis. Specific determination of 3-pyridylcarbinol was also carried out. Owing to its good selectivity, sensitivity and reproducibility, the method was applied to the analysis of urine samples from smokers and non-smokers. The results obtained suggest that the urinary markers used to assess active smoking or exposure to environmental tobacco smoke must be not only nicotine and cotinine, but also their main free and conjugated metabolites.

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