Methyl p-hydroxyphenyllactateCAS# 51095-47-7 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 51095-47-7 | SDF | Download SDF |
| PubChem ID | 170975 | Appearance | Solid |
| Formula | C10H12O4 | M.Wt | 196.2 |
| Type of Compound | Phenylpropanoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | methyl 2-hydroxy-3-(4-hydroxyphenyl)propanoate | ||
| SMILES | COC(=O)C(CC1=CC=C(C=C1)O)O | ||
| Standard InChIKey | PDFUCDWETSQSSU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H12O4/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7/h2-5,9,11-12H,6H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS) suggests that this interaction is responsible for the observed suppression of cell growth. |
Methyl p-hydroxyphenyllactate Dilution Calculator
Methyl p-hydroxyphenyllactate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.0968 mL | 25.4842 mL | 50.9684 mL | 101.9368 mL | 127.421 mL |
| 5 mM | 1.0194 mL | 5.0968 mL | 10.1937 mL | 20.3874 mL | 25.4842 mL |
| 10 mM | 0.5097 mL | 2.5484 mL | 5.0968 mL | 10.1937 mL | 12.7421 mL |
| 50 mM | 0.1019 mL | 0.5097 mL | 1.0194 mL | 2.0387 mL | 2.5484 mL |
| 100 mM | 0.051 mL | 0.2548 mL | 0.5097 mL | 1.0194 mL | 1.2742 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Pyrrolidinedithiocarbamate ammonium
Catalog No.:BCC6766
CAS No.:5108-96-3
- Boc-Lys(Z)-pNA
Catalog No.:BCC3419
CAS No.:51078-31-0
- ATC 0175 hydrochloride
Catalog No.:BCC7657
CAS No.:510733-97-8
- ATC 0065
Catalog No.:BCC7666
CAS No.:510732-84-0
- Wogonoside
Catalog No.:BCN1200
CAS No.:51059-44-0
- alpha-Lipomycin
Catalog No.:BCN1842
CAS No.:51053-40-8
- Z-GABA-OH,Z-gama-Abu-OH
Catalog No.:BCC2644
CAS No.:5105-78-2
- Flurbiprofen
Catalog No.:BCC3781
CAS No.:5104-49-4
- Acipimox
Catalog No.:BCC4884
CAS No.:51037-30-0
- Salbutamol Sulfate
Catalog No.:BCC4338
CAS No.:51022-70-9
- (-)-Licarin B
Catalog No.:BCN1241
CAS No.:51020-87-2
- (+)-Licarin A
Catalog No.:BCC9008
CAS No.:51020-86-1
- 2,7-Dihydrohomoerysotrine
Catalog No.:BCN5629
CAS No.:51095-85-3
- Nicotine 1'-N-oxide
Catalog No.:BCN6892
CAS No.:51095-86-4
- alpha-Onocerol
Catalog No.:BCN5630
CAS No.:511-01-3
- Sugiol
Catalog No.:BCN3164
CAS No.:511-05-7
- Totarol
Catalog No.:BCN4627
CAS No.:511-15-9
- Vitamin D4
Catalog No.:BCC2042
CAS No.:511-28-4
- Plumieride
Catalog No.:BCN5631
CAS No.:511-89-7
- Gitogenin
Catalog No.:BCN3886
CAS No.:511-96-6
- 8-Bromo-cGMP, sodium salt
Catalog No.:BCC6935
CAS No.:51116-01-9
- Cyclic Pifithrin-α hydrobromide
Catalog No.:BCC2407
CAS No.:511296-88-1
- (+)-trans-Isolimonene
Catalog No.:BCC9236
CAS No.:5113-87-1
- (S)-(+)-Ibuprofen
Catalog No.:BCC4042
CAS No.:51146-56-6
[Chemical constituents from Crepis crocea].[Pubmed:26975105]
Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(19):3800-4.
Thirteen compounds were isolated from the ethyl acetate fraction of Crepis crocea by column chromatographies on silica gel, Sephadex LH-20 and semi-preparative HPLC. The structures were elucidated on the basis of spectral analysis as tectorone I (1), 8beta- (2-methyl- 2-hydroxy-3-oxobutanoyloxy) -glucozaluzanin C (2), tectoroside (3), luteolin-7-O-glucoside (4), cosmosiin (5), esculetin (6), 3,4-dihydroxybenzaldehyde (7), trans-4-hydroxycinnamic acid (8), Caffeic acid (9), Methyl p-hydroxyphenyllactate (10), ethylp- hydroxyphenyllactate (11), cis-3,4-dihydroxy-beta-ionion (12). All the compounds, except for compounds 4 and 9, were isolated from this plant for the first time, and tectorone I (1) is a new natural product.
Type II estrogen binding site agonist: synthesis and biological evaluation of the enantiomers of methyl-para-hydroxyphenyllactate (MeHPLA).[Pubmed:12923805]
Chirality. 2003 Oct;15(8):674-9.
A high-affinity ligand for the type II estrogen binding site (EBS) was identified. Methyl para-hydroxyphenyllactate (MeHPLA) was observed to suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo. The high affinity of MeHPLA for the type II EBS suggests that this interaction is responsible for the observed suppression of cell growth. In this study, the enantiomers of MeHPLA were synthesized and separated by three methods and evaluated for biological activity. When the methods were compared, it was found that the method using an optically pure amine to form the diastereomers of the enantiomers gave the superior yield. Binding studies for the enantiomers to the type II EBS showed that the S-MeHPLA had a higher affinity for the binding site. However, higher binding affinity did not translate into superior cell growth suppression. Both enantiomers suppressed cell growth equally.
