Pinostilbene

CAS# 42438-89-1

Pinostilbene

Catalog No. BCN5483----Order now to get a substantial discount!

Product Name & Size Price Stock
Pinostilbene: 5mg $63 In Stock
Pinostilbene: 10mg Please Inquire In Stock
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Quality Control of Pinostilbene

Number of papers citing our products

Chemical structure

Pinostilbene

3D structure

Chemical Properties of Pinostilbene

Cas No. 42438-89-1 SDF Download SDF
PubChem ID 5473050 Appearance White-beige powder
Formula C15H14O3 M.Wt 242.3
Type of Compound Phenols Storage Desiccate at -20°C
Synonyms 3,4'-Dihydroxy 5-methoxy trans-stilbene
Solubility Soluble in methan
Chemical Name 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxyphenol
SMILES COC1=CC(=CC(=C1)O)C=CC2=CC=C(C=C2)O
Standard InChIKey KUWZXOMQXYWKBS-NSCUHMNNSA-N
Standard InChI InChI=1S/C15H14O3/c1-18-15-9-12(8-14(17)10-15)3-2-11-4-6-13(16)7-5-11/h2-10,16-17H,1H3/b3-2+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pinostilbene

The seeds of Vitis riparia

Biological Activity of Pinostilbene

Description1. Pinostilbene has protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells, it can reduce release of lactate dehydrogenase and activity of caspase-3 triggered by 6-hydroxydopamine (6-OHDA) in a dose-dependent manner. 2. Pinostilbene can significantly inhibit the growth of human colon cancer cells, i.e., HCT116 and HT29, 20 and 40 uM of pinostilbene causes cell cycle arrest at S phase and induces apoptosis in colon cancer cells.
TargetsCaspase | JNK

Pinostilbene Dilution Calculator

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Pinostilbene Molarity Calculator

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Preparing Stock Solutions of Pinostilbene

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1271 mL 20.6356 mL 41.2712 mL 82.5423 mL 103.1779 mL
5 mM 0.8254 mL 4.1271 mL 8.2542 mL 16.5085 mL 20.6356 mL
10 mM 0.4127 mL 2.0636 mL 4.1271 mL 8.2542 mL 10.3178 mL
50 mM 0.0825 mL 0.4127 mL 0.8254 mL 1.6508 mL 2.0636 mL
100 mM 0.0413 mL 0.2064 mL 0.4127 mL 0.8254 mL 1.0318 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pinostilbene

Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.[Pubmed:19443200]

J Nutr Biochem. 2010 Jun;21(6):482-9.

Resveratrol (3,4',5-trans-trihydroxystilbene) is a phytoalexin with emerging lines of evidence supporting its beneficial effects on cardiovascular systems and inhibition of carcinogenesis. It has also been reported that certain methylated resveratrol derivatives are more effective than resveratrol in the prevention/treatment of cancer. However, little is known about the impact of resveratrol and its derivatives on the development of Parkinson's disease. In this study, we compared the neuroprotective effects of resveratrol with four methylated (fully or partially) resveratrol derivatives against parkinsonian mimetic 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in SH-SY5Y cells. Release of lactate dehydrogenase and activity of caspase-3 triggered by 6-OHDA were significantly reduced by resveratrol and one of the methylated derivatives, Pinostilbene (3,4'-dihydroxy-5-methoxystilbene), in a dose-dependent manner. In addition, Pinostilbene exerted a potent neuroprotective effect with a wider effective concentration range than resveratrol. By using high-performance liquid chromatography, we found that uptake of Pinostilbene into SH-SY5Y cells was significantly higher than that of resveratrol. Enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of Pinostilbene. Moreover, Western blot analysis demonstrated that Pinostilbene markedly attenuated the phosphorylation of JNK and c-Jun triggered by 6-OHDA. Besides, mammalian target of rapamycin kinase may be an intracellular target accounting for the neuroprotective effects of Pinostilbene. Our findings demonstrate the potential of methylated stilbenes in neuroprotection and provide important information for further research in this field.

Description

Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells.

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