Primulic Acid 1CAS# 65312-86-9 |
Quality Control & MSDS
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| Cas No. | 65312-86-9 | SDF | Download SDF |
| PubChem ID | 49787015 | Appearance | White - beige powder |
| Formula | C54H88O23 | M.Wt | 1105.3 |
| Type of Compound | Isoprenoids | Storage | Desiccate at -20°C |
| Synonyms | Primulasaponin I; Saponin PS 4 | ||
| Solubility | Soluble in methan | ||
| Chemical Name | None | ||
| SMILES | CC1C(C(C(C(O1)OC2C(C(C(OC2OC3C(C(OC(C3OC4C(C(C(C(O4)CO)O)O)O)OC5CCC6(C(C5(C)C)CCC7(C6CCC89C7(CC(C1(C8CC(CC1)(C)C)CO9)O)C)C)C)C(=O)O)O)CO)O)O)O)O)O | ||
| Standard InChIKey | DQUUSJCGJNQFPG-CBMAJASRSA-N | ||
| Standard InChI | InChI=1S/C54H88O23/c1-22-30(58)33(61)36(64)44(70-22)76-41-35(63)32(60)24(20-56)72-46(41)74-39-38(66)40(43(67)68)75-47(42(39)77-45-37(65)34(62)31(59)23(19-55)71-45)73-29-11-12-50(6)25(49(29,4)5)9-13-51(7)26(50)10-14-54-27-17-48(2,3)15-16-53(27,21-69-54)28(57)18-52(51,54)8/h22-42,44-47,55-66H,9-21H2,1-8H3,(H,67,68)/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31+,32-,33+,34-,35-,36+,37+,38-,39-,40-,41+,42+,44-,45-,46-,47+,50-,51+,52-,53+,54-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Primulic Acid 1 Dilution Calculator
Primulic Acid 1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.9047 mL | 4.5237 mL | 9.0473 mL | 18.0946 mL | 22.6183 mL |
| 5 mM | 0.1809 mL | 0.9047 mL | 1.8095 mL | 3.6189 mL | 4.5237 mL |
| 10 mM | 0.0905 mL | 0.4524 mL | 0.9047 mL | 1.8095 mL | 2.2618 mL |
| 50 mM | 0.0181 mL | 0.0905 mL | 0.1809 mL | 0.3619 mL | 0.4524 mL |
| 100 mM | 0.009 mL | 0.0452 mL | 0.0905 mL | 0.1809 mL | 0.2262 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Saponins increase susceptibility of vancomycin-resistant enterococci to antibiotic compounds.[Pubmed:25544893]
Eur J Microbiol Immunol (Bp). 2014 Dec;4(4):204-12.
The resistance of commensal bacteria to first and second line antibiotics has reached an alarming level in many parts of the world and endangers the effective treatment of infectious diseases. In this study, the influence of the plant-derived natural saponins glycyrrhizic acid, beta-aescin, alpha-hederin, hederacoside C, and Primulic Acid 1 on the susceptibility of vancomycin-resistant enterococci (VRE) against antibiotics of clinical relevance was investigated in 20 clinical isolates. Furthermore, the antibacterial properties of saponins under study against VRE were determined in vitro. Results reveal that the susceptibility of VRE against gentamicin, teicoplanin, and daptomycin was enhanced in the presence of the saponin glycyrrhizic acid. Most importantly, glycyrrhizic acid (1 mg/ml) diminished the minimal inhibitory concentration (MIC) of gentamicin in gentamicin low-level intrinsic resistant VRE from 2 - >8 mg/l to Primulic Acid 1 to the antibiotics under study showed, compared to glycyrrhizic acid, less influence on the antibiotic potency. Only glycyrrhizic acid (1 mg/ml) and alphahederin (0.2 mg/ml) showed weak antibacterial properties against the clinical isolates. Our study points towards a therapeutic potential of saponins in the coapplication with antibiotics for bacterial infections.
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