Procyanidin A1

CAS# 103883-03-0

Procyanidin A1

Catalog No. BCN6809----Order now to get a substantial discount!

Product Name & Size Price Stock
Procyanidin A1: 5mg $184 In Stock
Procyanidin A1: 10mg Please Inquire In Stock
Procyanidin A1: 20mg Please Inquire Please Inquire
Procyanidin A1: 50mg Please Inquire Please Inquire
Procyanidin A1: 100mg Please Inquire Please Inquire
Procyanidin A1: 200mg Please Inquire Please Inquire
Procyanidin A1: 500mg Please Inquire Please Inquire
Procyanidin A1: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Procyanidin A1

Number of papers citing our products

Chemical structure

Procyanidin A1

3D structure

Chemical Properties of Procyanidin A1

Cas No. 103883-03-0 SDF Download SDF
PubChem ID 134715108 Appearance White-beige powder
Formula C30H24O12 M.Wt 576.5
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms (+)-Epicatechin-(4β-8,2β-O-7)-catechin; Proanthocyanidin A1
Solubility Soluble in methanol; sparingly soluble in water
Chemical Name (1R,5R,6S,13S,21S)-5,13-bis(3,4-dihydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.02,11.03,8.015,20]henicosa-2(11),3(8),9,15,17,19-hexaene-6,9,17,19,21-pentol
SMILES C1C(C(OC2=C3C4C(C(OC5=CC(=CC(=C45)O)O)(OC3=CC(=C21)O)C6=CC(=C(C=C6)O)O)O)C7=CC(=C(C=C7)O)O)O
Standard InChIKey NSEWTSAADLNHNH-LQBIBLAPSA-N
Standard InChI InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2/t21-,26+,27+,29-,30-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Procyanidin A1

1 Areca sp. 2 Litchi sp. 3 Rhododendron sp. 4 Theobroma sp. 5 Vitis sp.

Biological Activity of Procyanidin A1

Description1. Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2⁺ influx from an internal store in RBL-2H3 cells. 2. Procyanidin A1 shows a very high inhibition effect on LDL oxidation, with the IC50 value of 0.94 uM. 3. Procyanidin A1, A2, B1 and B2 are potential precursors of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone.
TargetsPKC | Calcium Channel | LDL | TNF-α | NF-kB | IkB | IKK

Procyanidin A1 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Procyanidin A1 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Procyanidin A1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7346 mL 8.673 mL 17.3461 mL 34.6921 mL 43.3651 mL
5 mM 0.3469 mL 1.7346 mL 3.4692 mL 6.9384 mL 8.673 mL
10 mM 0.1735 mL 0.8673 mL 1.7346 mL 3.4692 mL 4.3365 mL
50 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.6938 mL 0.8673 mL
100 mM 0.0173 mL 0.0867 mL 0.1735 mL 0.3469 mL 0.4337 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Procyanidin A1

Procyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation.[Pubmed:24297667]

Arch Pharm Res. 2014 Nov;37(11):1403-10.

The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, Procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin B (5), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 muM, respectively.

Effects of peanut-skin procyanidin A1 on degranulation of RBL-2H3 cells.[Pubmed:21897038]

Biosci Biotechnol Biochem. 2011;75(9):1644-8.

Peanut skin contains large amounts of polyphenols having antiallergic effects. We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m/z 599 [M+Na](+). Based on the results of (1)H-NMR, (1)(3)C-NMR spectra, and optical rotation analysis, the polyphenol was identified as Procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC(5)(0) of 20.3 microM. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by Procyanidin A1. These results indicate that peanut-skin Procyanidin A1 inhibits degranulation downstream of protein kinase C activation or Ca(2)(+) influx from an internal store in RBL-2H3 cells.

5-(3',4'-Dihydroxyphenyl-gamma-valerolactone), a Major Microbial Metabolite of Proanthocyanidin, Attenuates THP-1 Monocyte-Endothelial Adhesion.[Pubmed:28672844]

Int J Mol Sci. 2017 Jun 26;18(7). pii: ijms18071363.

Several metabolomics of polymeric flavan-3-ols have reported that proanthocyanidins are extensively metabolized by gut microbiota. 5-(3',4'-dihydroxyphenyl)-gamma-valerolactone (DHPV) has been reported to be the major microbial metabolite of proanthocyanidins. We demonstrated that DHPV has stronger prevention effect on tumor necrosis factor (TNF)-alpha-stimulated adhesion of THP-1 human monocytic cells to human umbilical vein endothelial cells compared to its potential precursors such as Procyanidin A1, A2, B1 and B2, (+)catechin, (-)epicatechin and its microbial metabolites such as 3-(3,4-dihydroxyphenyl)propionic acid and 2-(3,4-dihydroxyphenyl)acetic acid. Mechanism study showed that DHPV prevents THP-1 monocyte-endothelial cell adhesion by downregulating TNF-alpha-stimulated expressions of the two biomarkers of atherosclerosis such as vascular cell adhesion molecule-1 and monocyte chemotactic protein-1, activation of nuclear factor kappa B transcription and phosphorylation of I kappa-B kinase and IkappaBalpha. We suggested that DHPV has higher potentiality in prevention of atherosclerosis among the proanthocyanidin metabolites.

Description

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

Keywords:

Procyanidin A1,103883-03-0,(+)-Epicatechin-(4β-8,2β-O-7)-catechin; Proanthocyanidin A1,Natural Products, buy Procyanidin A1 , Procyanidin A1 supplier , purchase Procyanidin A1 , Procyanidin A1 cost , Procyanidin A1 manufacturer , order Procyanidin A1 , high purity Procyanidin A1

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: