Pyromeconic acidCAS# 496-63-9 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 496-63-9 | SDF | Download SDF |
| PubChem ID | 68129 | Appearance | Powder |
| Formula | C5H4O3 | M.Wt | 112.08 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-hydroxypyran-4-one | ||
| SMILES | C1=COC=C(C1=O)O | ||
| Standard InChIKey | VEYIMQVTPXPUHA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C5H4O3/c6-4-1-2-8-3-5(4)7/h1-3,7H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Pyromeconic acid and derivatives thereof are potent inhibitors of endonuclease, it shows siderophile activity. |
| Targets | Antifection |
| Kinase Assay | Fragment-Based Identification of Influenza Endonuclease Inhibitors.[Pubmed: 27291165 ]J Med Chem. 2016 Jul 14;59(13):6444-54.The influenza virus is responsible for millions of cases of severe illness annually. Yearly variance in the effectiveness of vaccination, coupled with emerging drug resistance, necessitates the development of new drugs to treat influenza infections. One attractive target is the RNA-dependent RNA polymerase PA subunit. |
| Structure Identification | Biosci Biotechnol Biochem. 1995 May;59(5):886-90.Pyromeconic acid and its glucosidic derivatives from leaves of Erigeron annuus, and the siderophile activity of pyromeconic acid.[Pubmed: 7787303]3'-O-Caffeylerigeroside (Pyromeconic acid 3-O-beta-D-glucoside 3'-O-caffeyl ester) was obtained from the leaves of Erigeron annuus as a new Pyromeconic acid derivative, and its structure was elucidated. Together with the gamma-pyrone derivative, Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and its beta-glucoside (erigeroside) were also isolated from the aerial parts of E. annuus. The siderophile activity of Pyromeconic acid was also studied. |
Pyromeconic acid Dilution Calculator
Pyromeconic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 8.9222 mL | 44.611 mL | 89.222 mL | 178.444 mL | 223.055 mL |
| 5 mM | 1.7844 mL | 8.9222 mL | 17.8444 mL | 35.6888 mL | 44.611 mL |
| 10 mM | 0.8922 mL | 4.4611 mL | 8.9222 mL | 17.8444 mL | 22.3055 mL |
| 50 mM | 0.1784 mL | 0.8922 mL | 1.7844 mL | 3.5689 mL | 4.4611 mL |
| 100 mM | 0.0892 mL | 0.4461 mL | 0.8922 mL | 1.7844 mL | 2.2305 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Benzofuran-2-carboxylic acid
Catalog No.:BCC8851
CAS No.:496-41-3
- Fenofibrate
Catalog No.:BCC4781
CAS No.:49562-28-9
- Estradiol heptanoate
Catalog No.:BCC8961
CAS No.:4956-37-0
- 11alpha,12alpha-Oxidotaraxerol palmitate
Catalog No.:BCN7129
CAS No.:495389-95-2
- Org 25543 hydrochloride
Catalog No.:BCC6288
CAS No.:495076-64-7
- (+)-Methysticin
Catalog No.:BCN8429
CAS No.:495-85-2
- Tigloyltropeine
Catalog No.:BCN1944
CAS No.:495-83-0
- Valtropine
Catalog No.:BCN1926
CAS No.:495-82-9
- Tropine isobutyrate
Catalog No.:BCN1923
CAS No.:495-80-7
- Desoxypeganine
Catalog No.:BCN8032
CAS No.:495-59-0
- Nodakenetin
Catalog No.:BCN5604
CAS No.:495-32-9
- Nodakenin
Catalog No.:BCN2378
CAS No.:495-31-8
- Helicianeoide A
Catalog No.:BCN2486
CAS No.:496066-82-1
- Helicianeoide B
Catalog No.:BCN2487
CAS No.:496066-89-8
- Tetraethylenepentamine 5HCl
Catalog No.:BCC3867
CAS No.:4961-41-5
- Robustaflavone
Catalog No.:BCN8285
CAS No.:49620-13-5
- Angelicain
Catalog No.:BCN5605
CAS No.:49624-66-0
- Isomitraphylline
Catalog No.:BCN7800
CAS No.:4963-01-3
- Simiarenol acetate
Catalog No.:BCN5606
CAS No.:4965-99-5
- ZLN005
Catalog No.:BCC4882
CAS No.:49671-76-3
- Eltrombopag
Catalog No.:BCC4968
CAS No.:496775-61-2
- Eltrombopag Olamine
Catalog No.:BCC1549
CAS No.:496775-62-3
- Crobarbatine
Catalog No.:BCN2069
CAS No.:49679-23-4
- AR-C155858
Catalog No.:BCC1367
CAS No.:496791-37-8
Fragment-Based Identification of Influenza Endonuclease Inhibitors.[Pubmed:27291165]
J Med Chem. 2016 Jul 14;59(13):6444-54.
The influenza virus is responsible for millions of cases of severe illness annually. Yearly variance in the effectiveness of vaccination, coupled with emerging drug resistance, necessitates the development of new drugs to treat influenza infections. One attractive target is the RNA-dependent RNA polymerase PA subunit. Herein we report the development of inhibitors of influenza PA endonuclease derived from lead compounds identified from a metal-binding pharmacophore (MBP) library screen. Pyromeconic acid and derivatives thereof were found to be potent inhibitors of endonuclease. Guided by modeling and previously reported structural data, several sublibraries of molecules were elaborated from the MBP hits. Structure-activity relationships were established, and more potent molecules were designed and synthesized using fragment growth and fragment merging strategies. This approach ultimately resulted in the development of a lead compound with an IC50 value of 14 nM, which displayed an EC50 value of 2.1 muM against H1N1 influenza virus in MDCK cells.
Pyromeconic acid and its glucosidic derivatives from leaves of Erigeron annuus, and the siderophile activity of pyromeconic acid.[Pubmed:7787303]
Biosci Biotechnol Biochem. 1995 May;59(5):886-90.
3'-O-Caffeylerigeroside (Pyromeconic acid 3-O-beta-D-glucoside 3'-O-caffeyl ester) was obtained from the leaves of Erigeron annuus as a new Pyromeconic acid derivative, and its structure was elucidated. Together with the gamma-pyrone derivative, Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and its beta-glucoside (erigeroside) were also isolated from the aerial parts of E. annuus. The siderophile activity of Pyromeconic acid was also studied.
Three pyrone glucosidic derivatives from Conyza albida.[Pubmed:12143010]
Planta Med. 2002 Jul;68(7):664-6.
Three new pyrone glucosidic derivatives, together with the known Pyromeconic acid glucoside, three acytelenes and two eudesmanes, were obtained from the aerial parts of Conyza albida. The structures were elucidated by high field NMR spectroscopy.
[Isolation and structure of 6'-O-caffeylerigeroside from Erigeron multiradiatus].[Pubmed:12016944]
Yao Xue Xue Bao. 1998 Nov;33(11):836-8.
The plant, Erigeron multiradiatus (Wall.) Benth(Family: Compositae), is a perennial herb distributed abundantly in the mountainous area of the southwestern part in China. It is used in folk medicine for the treatment of common cold, panting cough, rheumatic, enteritis and toothache. In this paper, we report a new glycoside named as 6'-O-caffeylerigeroside isolated from Erigeron Multiradiatus (Family: Compositae) together with four known compounds. The known compounds were identified as Pyromeconic acid(I), scopoletin(II), 4-hydroxybenzoic acid(III) and vanillic acid(IV). The structure of 6'-O-caffeylerigeroside was elucidated as gamma-pyrone-3-O-[6"-(3',4'-dihydroxy-cinnamoyl)]-beta-D-glucoside(V) on the basis of chemical evidence and spectral data.
Two new glycosides from Vitex negundo.[Pubmed:23356826]
Nat Prod Res. 2013 Oct;27(20):1837-41.
Two new glycosides, 2-methyl Pyromeconic acid 3-O-beta-D-glucopyranoside-6'-(O-4''-hydroxybenzoate) (1), 6'-O-p-hydroxybenzoyl-gardoside (2) and four known iridoid glycosides (3-6) were isolated from the whole plant of Vitex negundo. Their structures were elucidated on the basis of spectroscopic methods including HR-ESI-MS, 1D and 2D NMR.
