Spicatine ACAS# 124256-81-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 124256-81-1 | SDF | Download SDF |
| PubChem ID | 138402864.0 | Appearance | Powder |
| Formula | C34H49NO10 | M.Wt | 631.76 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(2R,5R,6S,7S,8R,9R,10S,13R,14R,17S,18R)-8-ethoxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate | ||
| SMILES | CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)OCC)OC)OC)O)COC | ||
| Standard InChIKey | YFNWMBCDYXJELF-HPWVRHJRSA-N | ||
| Standard InChI | InChI=1S/C34H49NO10/c1-7-35-16-31(17-40-3)20(36)14-21(41-4)33-19-15-32(39)28(45-30(38)18-12-10-9-11-13-18)22(19)34(44-8-2,27(37)29(32)43-6)23(26(33)35)24(42-5)25(31)33/h9-13,19-29,36-37,39H,7-8,14-17H2,1-6H3/t19-,20-,21?,22?,23+,24+,25-,26+,27+,28?,29+,31+,32-,33?,34-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Spicatine A Dilution Calculator
Spicatine A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5829 mL | 7.9144 mL | 15.8288 mL | 31.6576 mL | 39.572 mL |
| 5 mM | 0.3166 mL | 1.5829 mL | 3.1658 mL | 6.3315 mL | 7.9144 mL |
| 10 mM | 0.1583 mL | 0.7914 mL | 1.5829 mL | 3.1658 mL | 3.9572 mL |
| 50 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.6332 mL | 0.7914 mL |
| 100 mM | 0.0158 mL | 0.0791 mL | 0.1583 mL | 0.3166 mL | 0.3957 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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C19-Norditerpenoid Alkaloids from Aconitum szechenyianum.[Pubmed:29738430]
Molecules. 2018 May 8;23(5):1108.
Three new C(19)-norditerpenoid alkaloids (1(-)3), along with two known C(19)-norditerpenoid alkaloids (4,5), have been isolated from Aconitum szechenyianum. Based on extensive spectroscopic techniques (1D, 2D-NMR, IR, and MS) and chemical methods, their structures were established as szechenyianine D (1), szechenyianine E (2), szechenyianine F (3), 8-O-methyl-14-benzoylaconine (4), and Spicatine A (5). The immunosuppressive effects of compounds 1(-)5 were studied using a ConA-induced or LPS-induced splenocyte proliferation model. In vitro tests showed that Compounds 2, 4, and 5 suppressed ConA-induced or LPS-induced splenocyte proliferation in a concentration-dependent manner. The CC(50)/IC(50) values of 2, 4, and 5 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis.
A new C(20)-diterpenoid alkaloid from Aconitum soongaricum var. pubescens.[Pubmed:27328130]
Nat Prod Res. 2017 Mar;31(5):523-528.
A new denudatine-type C(20)-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), Spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.
