Varlitinib (ARRY334543)ErbB inhibitor CAS# 845272-21-1 |
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Quality Control & MSDS
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| Cas No. | 845272-21-1 | SDF | Download SDF |
| PubChem ID | 42642648 | Appearance | Powder |
| Formula | C22H19ClN6O2S | M.Wt | 466.94 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | ARRY-334543 | ||
| Solubility | DMSO : 50 mg/mL (107.08 mM; Need ultrasonic) | ||
| Chemical Name | 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine | ||
| SMILES | CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl | ||
| Standard InChIKey | UWXSAYUXVSFDBQ-CYBMUJFWSA-N | ||
| Standard InChI | InChI=1S/C22H19ClN6O2S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28)/t13-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Varlitinib is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2) with IC50 values of 7 nM and 2 nM, respectively. | |||||
| Targets | ErbB2 | ErbB1 | ||||
| IC50 | 2 nM | 7 nM | ||||
Varlitinib (ARRY334543) Dilution Calculator
Varlitinib (ARRY334543) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1416 mL | 10.708 mL | 21.416 mL | 42.8321 mL | 53.5401 mL |
| 5 mM | 0.4283 mL | 2.1416 mL | 4.2832 mL | 8.5664 mL | 10.708 mL |
| 10 mM | 0.2142 mL | 1.0708 mL | 2.1416 mL | 4.2832 mL | 5.354 mL |
| 50 mM | 0.0428 mL | 0.2142 mL | 0.4283 mL | 0.8566 mL | 1.0708 mL |
| 100 mM | 0.0214 mL | 0.1071 mL | 0.2142 mL | 0.4283 mL | 0.5354 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Varlitinib is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.
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Varlitinib (ARRY-334543; ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.
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